New Treatment for Psoriasis: Therapeutic Efficiency in Patients and Antiinflammatory Effect in Vitro

Umbert, Ignacio J.; Márquez-Kisinousky, Leonardo; Farrera, Consol; Valls, J. Gutierrez; Fernández, Annabel Valledor; Fernández-Fernández, Laura

doi:10.19080/jojdc.2020.03.555604

JOJDC

2020

DOI: 10.19080/jojdc.2020.03.555604

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New Treatment for Psoriasis: Therapeutic Efficiency in Patients and Antiinflammatory Effect in Vitro

Ignacio J. Umbert¹,

Leonardo Márquez-Kisinousky²,

Consol Farrera³

et al.

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2024

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Unraveling Mitochondrial Reactive Oxygen Species Involvement in Psoriasis: The Promise of Antioxidant Therapies

Ahmad Jamil,

Abdul Karim

2024

Antioxidants

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Psoriasis is a chronic inflammatory skin disorder characterized by immune dysregulation and aberrant keratinocyte proliferation. Despite tremendous advances in understanding its etiology, effective therapies that target its fundamental mechanisms remain necessary. Recent research highlights the role of reactive oxygen species dysregulation and mitochondrial dysfunction in psoriasis pathogenesis. Mitochondrial reactive oxygen species mediate cellular signaling pathways involved in psoriasis, such as proliferation, apoptosis, and inflammation, leading to oxidative stress, exacerbating inflammation and tissue damage if dysregulated. This review explores oxidative stress biomarkers and parameters in psoriasis, including myeloperoxidase, paraoxonase, sirtuins, superoxide dismutase, catalase, malondialdehyde, oxidative stress index, total oxidant status, and total antioxidant status. These markers provide insights into disease mechanisms and potential diagnostic and therapeutic targets. Modulating mitochondrial reactive oxygen species levels and enhancing antioxidant defenses can alleviate inflammation and oxidative damage, improving patient outcomes. Natural antioxidants like quercetin, curcumin, gingerol, resveratrol, and other antioxidants show promise as complementary treatments targeting oxidative stress and mitochondrial dysfunction. This review aims to guide the development of personalized therapeutic methods and diagnostic techniques, emphasizing the importance of comprehensive clinical studies to validate the efficacy and safety of these interventions, paving the way for more effective and holistic psoriasis care.

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Unraveling Mitochondrial Reactive Oxygen Species Involvement in Psoriasis: The Promise of Antioxidant Therapies

Ahmad Jamil,

Abdul Karim

2024

Antioxidants

View full text Add to dashboard Cite

show abstract

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New Treatment for Psoriasis: Therapeutic Efficiency in Patients and Antiinflammatory Effect in Vitro

Cited by 1 publication

References 12 publications

Unraveling Mitochondrial Reactive Oxygen Species Involvement in Psoriasis: The Promise of Antioxidant Therapies

Unraveling Mitochondrial Reactive Oxygen Species Involvement in Psoriasis: The Promise of Antioxidant Therapies

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