New Treatment Options against Gram-negative Organisms

Bassetti, Matteo; Ginocchio, Francesca; Mikulska, Małgorzata

doi:10.1007/978-3-642-18081-1_46

Cited by 28 publications

(30 citation statements)

References 49 publications

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“…Limited penetration of antibiotics to achieve therapeutic concentrations in CSF poses an additional problem in central nervous system infections (16)(17)(18). A baumannii resistance is a recognized problem worldwide; the WHO has recognized antimicrobial resistance as one of the three most important problems to human health (19) and has registered A baumannii as a nosocomial pathogen in which resistance is of great public health concern (20).…”

Section: Discussionmentioning

confidence: 99%

Successful Management of Nosocomial Ventriculitis and Meningitis Caused by Extensively Drug‐Resistant Acinetobacter baumannii in Austria

Hoenigl

Drescher

Feierl

et al. 2013

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Nosocomial infections caused by the Gram-negative coccobacillus Acinetobacter baumannii have substantially increased over recent years. Because Acinetobacter is a genus with a tendency to quickly develop resistance to multiple antimicrobial agents, therapy is often complicated, requiring the return to previously used drugs. The authors report a case of meningitis due to extensively drug-resistant A baumannii in an Austrian patient who had undergone neurosurgery in northern Italy. The case illustrates the limits of therapeutic options in central nervous system infections caused by extensively drug-resistant pathogens.

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Section: Discussionmentioning

confidence: 99%

Successful Management of Nosocomial Ventriculitis and Meningitis Caused by Extensively Drug‐Resistant Acinetobacter baumannii in Austria

Hoenigl

Drescher

Feierl

et al. 2013

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…This rapid spread of resistance among pathogenic microorganisms is a serious problem globally (2,4), because it limits the drug treatment alternative against infections (15). Antimicrobial resistance has presently been recognized as one of the most important problems facing human health by the World Health Organization (WHO) (15,16). Frequent isolation of multidrug resistant (MDR) pathogens in both hospital and community acquired infections further intensi ed the problem of antimicrobial resistance (5).…”

Section: Introductionmentioning

confidence: 99%

“…This can have a potentially serious impact on human health. The situation is more common in developing countries where there is widespread and uncontrolled use of antibiotics (16). Data on extended-spectrum β-lactamases producing Enterobacteriaceae in Ethiopia are limited and there is no data associated with this.…”

Section: Introductionmentioning

confidence: 99%

Faecal Carriage Rate of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella Pneumonia Among Apparently Health Food Handlers in Dilla University Student Cafeteria

Diriba

Awulachew

Takele

et al. 2020

Preprint

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Background: The rapid spread of extended-spectrum β- lactamases (ESBL) producing enterobacteriaceae among food handlers, which can cause food borne outbreaks, is a public health concern and become a serious world threat. Klebsiella pneumoniae and Escherichia coli are the predominant ESBL-producing enterobacteriaceae. There is no sufficient data related to this in underdeveloped countries. Objective: This study was aimed assess the magnitude of ESBL producing Klebsiella pneumoniae and Escherichia coli isolated from stool of apparently health food handlers in the Dilla University Student Cafeteria. Methods: A cross-sectional study was conducted from November to September 2018/2019. A structured questionnaire was used for collection of data on socio- demographics. A total of 220 stool samples were cultured on MacConkey agar and a series of biochemical tests was done for the identification of bacterial species. Double-disk synergy (DDS) method was used for the detection of ESBL-producing strains. A disc of amoxicillin clavulanic acid was placed in the center of the Mueller–Hinton agar plate, and cefotaxime, aztreonam, and ceftazidime were placed at a distance of 20mm from the disk placed at center. Enhanced inhibition zone of any of the cephalosporin discs on the side facing amoxicillin clavulanic acid was considered as ESBL producer. Results: The rate of faecal carriage of E. coli and K. pneumonia among the food handlers of the current study was found to be 66.4%, of which 81.5% was E. coli, while 18.5% was K. pneumonia. From the total bacterial isolates, 25.3% were confirmed to be positive for ESBL production of which 19.9% was E. coli, while 5.5% was K. pneumonia. ESBL-producing faecal carriage showed high resistance to aztreonam, cefotaxime, ceftriaxone, cefuroxime, and ceftazidime with resistance rate ranged from 88-100%, while the least resistance rate was seen against imipenem accounted <26.3%. In this study, around 91.9% of ESBL-producing isolates were co-resistant to β -lactams antibiotics plus at least one of the non β -lactam antibiotics. Only food handlers who used antibiotics repeatedly in the last 3months were significantly associated with the ESBL carriage with P values of 0.001, 95% CI (1.12-3.18). Conclusion: The magnitude of ESBL-producing E. coli and K. pneumonia faecal carriage is alarmingly high and a threat to human health. The occurrence of multidrug resistance to third-generation cephalosporins and non-β lactam antibiotics is more common among ESBL producers. Detecting and reporting of ESBL-producing organisms have a remarkable importance in clinical decision-making. Hence, a coordinated effort should be implemented for the prevention and control the disease Enterobacteriaceae

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“….. .......................................................................................................... 73 Figura 12. Imagens obtidas por MEV da NPs (A); das NPs interagindo com 4,4x10 3 (B) ou 8,9x10 5 UFC/mL (C) de P. aeruginosa MR. Imagens de MEV da interação de PDDA (a 1,0 mg/mL de concentração final) com 8,9x10 5 (Bassetti et al, 2011), o que gera impacto econômico e social sobre o sistema de saúde em todo o mundo As principais formas de resistência a antimicrobianos ocorrem por inativação enzimática do fármaco, modificação do alvo do antimicrobiano, diminuição da entrada do antimicrobiano na célula microbiana e efluxo do fármaco (Brooks e Brooks, 2014). Além disso, a disseminação dessas formas de resistência ocorre facilmente e pelo mundo todo, e o uso indiscriminado de antimicrobianos é o fator mais importante que contribui para o surgimento de resistência (CDC, 2013).…”

Section: Introductionunclassified

Arrranjos supramoleculares de lípide catiônico, antibióticos e polímeros: preparação, caracterização e atividade contra bactérias multirresistentes e micobactérias de crescimento rápido

Carrasco¹

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New Treatment Options against Gram-negative Organisms

Cited by 28 publications

References 49 publications

Successful Management of Nosocomial Ventriculitis and Meningitis Caused by Extensively Drug‐Resistant Acinetobacter baumannii in Austria

Successful Management of Nosocomial Ventriculitis and Meningitis Caused by Extensively Drug‐Resistant Acinetobacter baumannii in Austria

Faecal Carriage Rate of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella Pneumonia Among Apparently Health Food Handlers in Dilla University Student Cafeteria

Arrranjos supramoleculares de lípide catiônico, antibióticos e polímeros: preparação, caracterização e atividade contra bactérias multirresistentes e micobactérias de crescimento rápido

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