New treatment options for pterygium

Fuest, Matthias; Coroneo, Minas T.

doi:10.1080/17469899.2017.1324297

Cited by 12 publications

(13 citation statements)

References 25 publications

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“… 11 Therefore, the ophthalmic surgeons decided to use multiple kinds of medications before, during, or after the operation to reduce the hyperproliferation of fibrovascular tissue and thereby reduce the recurrence rate. MMC, 58 59 60 5-ﬂuorouracil (5-FU), 19 59 61 corticosteroids, 61 and anti-VEGFs are the most popular agents. Daunorubicin and doxorubicin have also been used as adjuvants to prevent recurrences and have shown preliminary promising results in some studies.…”

Section: R Esultsmentioning

confidence: 99%

Recurrent Pterygium

Abolfathzadeh

Ghiasian

Samavat

et al. 2021

Journal of Current Ophthalmology

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Purpose: To summarize the recent evidence regarding different aspects of pterygium recurrence. Methods: Human-based studies from PubMed, Scopus, and Google Scholar were identified using the following keywords: conjunctival disease, pterygium, recurrent pterygium, pterygium recurrence, pterygium management/surgery, conjunctival autograft (CAU), amniotic membrane graft/transplant, and adjuvant therapy (January 2009 to February 2021). We reviewed risk factors associated with the recurrence of pterygium, timing of recurrence, medical treatments to prevent from recurrence, and nonsurgical and surgical alternatives for management of recurrence. Results: Dry eye disease, black race, and young age are considered definite risk factors for recurrence. However, fleshy appearance of the pterygium and preoperative size remain controversial. Surgical techniques such as excessive suturing, insufficient conjunctival graft size, thick conjunctival graft with remained Tenon tissue, and postoperative graft retraction are considered possible risk factors for recurrence. Using fibrin glue instead of sutures can further reduce recurrence rates. Although recurrence could occur even after many years, most recurrences happen in the first 3–6 months after surgery. Multiple kinds of adjuvant medications are used before, during, or after the operation including mitomycin C (MMC), 5-ﬂuorouracil (5-FU), corticosteroids, and anti-vascular endothelial growth factors (anti-VEGFs). Multiple weekly subconjunctival 5-FU injections are shown to be safe and effective in halting the progression of recurrent pterygium. Although topical bevacizumab is found to inhibit the growth of impending recurrent pterygium, the effect is mostly temporary. CAU is superior to amniotic membrane transplantation in the treatment for recurrent pterygia. Conclusions: There is yet to be a panacea in treating recurrent pterygium. Currently, there is not a globally accepted recommendation for treating recurrent pterygium with anti-VEGFs or 5-FU as a nonsurgical treatment. We strongly recommend using MMC as an adjunct to surgery in recurrent cases, with consideration of its specific complications. CAU is the most effective surgical treatment for recurrent pterygium, and other new surgical therapies need further investigation.

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Section: R Esultsmentioning

confidence: 99%

Recurrent Pterygium

Abolfathzadeh

Ghiasian

Samavat

et al. 2021

Journal of Current Ophthalmology

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“…Among the various available treatment modalities, excision of pterygium and covering the bare sclera with conjunctival autograft including limbal stem cells is the most effective method. It prevents recurrence to a great extent 3 . Limbal stem cells included in the autograft act as a barrier to conjunctival cell migration onto the corneal surface 8,9 .…”

Section: Discussionmentioning

confidence: 99%

Conjunctival Autograft using Autologous Serum versus Suturing Technique in Primary Pterygium: A Randomised, Prospective, Comparative Study

Minj¹

2018

jmscr

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“…Ultraviolet light is a major risk factor, so the prevalence of the disease is high among people in the peri-equatorial latitudes, mountainous and highly reflective environments. 1 influential factors for pterygium recurrence. [2][3][4] To improve the training processes and surgical outcomes, we are interested in the results of pterygium surgery operated by first-year ophthalmology residents at Thammasat hospital.…”

Section: Introductionmentioning

confidence: 99%