New Trends and Perspectives in the Evolution of Neurotransmitters in Microbial, Plant, and Animal Cells

Roshchina, Victoria V.

doi:10.1007/978-3-319-20215-0_2

Cited by 123 publications

(85 citation statements)

References 207 publications

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“…In addition to the overall changes in microbial profiles, the present study also assessed functional alterations in the fecal microbiome of the BD samples. As previously reported, several strains of gut flora have the potential to produce serotonin, which is a metabolite of the amino acid tryptophan and plays an important role in the regulation of mood. Additionally, it is possible that the over‐represented LPS biosynthesis genes may be related to the overgrowth of Enterobacter in the gut of active‐BD patients.…”

Section: Discussionmentioning

confidence: 82%

The microbiome in bipolar depression: A longitudinal study of one pair of monozygotic twins

Jiang

Zhang

et al. 2019

Bipolar Disorders

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The commensal gut microbiota is a dynamic entity that is influenced by a variety of factors. Previous study 1 has reported considerable individual variability in the bacterial content between related and unrelated individuals, which makes it difficult to identify candidate microorganisms for specific diseases. However, findings from monozygotic (MZ) twins have revealed a high degree of similarity in the composition of gut microbiota between twins. 1 Therefore, MZ twins discordant for a particular disease phenotype represent an attractive model for studying relationships between a disease and the microbiome.Bipolar disorder is a common and severe psychiatric illness characterized by at least one episode of hypomania and at least one episode of major depression. Despite the apparently high heritability of BD, there is considerable discordance between MZ twin pairs, which suggests that nongenetic and presumably environmental factors also play a role. Over the past decade, mounting evidence from animal studies has indicated that the gut microbiota is essential for brain function. In one recent study, 2 Evans et al characterized the fecal microbiome of 115 patients with bipolar disorder, and found decreased fractional representation of Faecalibacterium and an unclassified member from the Ruminococcaceae family compared to those of healthy control subjects. However, that study was limited to a single timepoint and thus did not capture the dynamics of the gut microbiome over time. Moreover, the detection of patterns in the gut microbiota may be complicated by variations in the severity of symptoms and the effects of antipsychotic drugs. As a result, it is of critical importance to study the intestinal microbiome over the whole process of a disease to identify whether there are microbial signatures related to that disorder. This can be achieved by longitudinal studies that begin at diagnosis and include follow-up assessments throughout treatment and that occur in parallel with clinical characterization.Thus, the primary aims of the present study were as follows: (1) to determine whether the gut microbiota of a single pair of MZ twins discordant for BD would have a lower degree of similarity than those of two healthy spouses; (2) to investigate whether there are differences in the composition and function of the gut microbiota during the active state of BD compared to that of healthy individuals; (3) and, in particular, to evaluate changes in the compositional and functional profiles of the microbiota of the affected twin according to disease state over a 7-month follow-up period. | C A S E-PR E S E NTATI O NThe subjects included one pair of MZ twins discordant for bipolar depression (BD) and two pair of spouses recruited from Hangzhou who were used as a healthy control (HC) group. The study protocol was approved by the Ethics Committee of the First Affiliated Hospital of Zhejiang University (Zhejiang, China), and the written consent of all subjects was obtained prior to sample collection and the subsequent analyses. The ...

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Section: Discussionmentioning

confidence: 82%

The microbiome in bipolar depression: A longitudinal study of one pair of monozygotic twins

Jiang

Zhang

et al. 2019

Bipolar Disorders

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“…synaptobrevin2, syntaxin1) and their interacting partners (e.g. tomosyn) have been even identified in fungi and plants [31]. …”

Section: Most Nervous System Components Have Ancient Originsmentioning

confidence: 99%

Back to the Basics: Cnidarians Start to Fire

Bosch

Klimovich

Domazet-Lošo

et al. 2017

Trends in Neurosciences

117

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The nervous systems of cnidarians, pre-bilaterian animals that diverged close to the base of the metazoan radiation, are structurally simple and thus have great potential to inform us about basic structural and functional principles of neural circuits. Unfortunately, cnidarians have thus far been relatively intractable to electrophysiological and genetic techniques and consequently have been largely passed over by neurobiologists. However, recent advances in molecular and imaging methods are fueling a renaissance of interest in and research into cnidarians nervous systems. Here, we review current knowledge on the nervous systems of some cnidarian species and propose that researchers should seize this opportunity and undertake the study of this phylum as strategic experimental systems with great basic and translational relevance for neuroscience.

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“…Recent studies had focused on the role of intestinal microbiota in regulating the blood levels of 5‐HT. Studies have proved that corynebacterium, streptococcus, and E.coli may produce 5‐HT in culture (Roshchina, ). The serum concentration of 5‐HT in GF mice was significantly lower than that in normal mice (Sjogren et al., ).…”

Section: Effect Of Microbiota On Hormone and Bone Homeostasismentioning

confidence: 99%

Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity

Rao

Cheng

et al. 2019

MicrobiologyOpen

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The complex relationship between intestinal microbiota and host is a novel field in recent years. A large number of studies are being conducted on the relationship between intestinal microbiota and bone metabolism. Bone metabolism consisted of bone absorption and formation exists in the whole process of human growth and development. The nutrient components, inflammatory factors, and hormone environment play important roles in bone metabolism. Recently, intestinal microbiota has been found to influence bone metabolism via influencing the host metabolism, immune function, and hormone secretion. Here, we searched relevant literature on Pubmed and reviewed the effect of intestinal microbiota on bone metabolism through the three aspects, which may provide new ideas and targets for the clinical treatment of osteoporosis.

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New Trends and Perspectives in the Evolution of Neurotransmitters in Microbial, Plant, and Animal Cells

Cited by 123 publications

References 207 publications

The microbiome in bipolar depression: A longitudinal study of one pair of monozygotic twins

The microbiome in bipolar depression: A longitudinal study of one pair of monozygotic twins

Back to the Basics: Cnidarians Start to Fire

Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity

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