New Trends in Chronotoxicology

Cambar, J.; Pons, M.

doi:10.1007/978-3-662-09355-9_20

Cited by 10 publications

(3 citation statements)

References 45 publications

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“…Chronotoxicology is the study of biological time-dependent differences in the adverse effects of xenobiotic substances17, 24, 55, 56 ) . Hundreds of animal and human research studies corroborate the CTS mediates the responses to and consequences of a wide variety of toxic challenges.…”

Section: Chronotoxicologymentioning

confidence: 99%

Working Time Society consensus statements: Circadian time structure impacts vulnerability to xenobiotics—relevance to industrial toxicology and nonstandard work schedules

2019

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The circadian time structure (CTS) has long been the subject of research in occupational medicine, but not to industrial toxicology, including methods of setting threshold limit values (TLVs) and employee biological monitoring. Numerous animal and human investigations document vulnerability to chemical, contagion, and other xenobiotics varies according to the circadian time of encounter. Permanent and rotating nightshift personnel are exposed to industrial contaminants in the same or higher concentration as dayshift personnel, and because of incomplete CTS adjustment to night work, contact with contaminants occurs during a different biological time than day workers. Thus, the amount of protection afforded by certain TLVs, especially for employees of high-risk settings who work night and other nonstandard shift schedules, might be inadequate. The CTS seems additionally germane to procedures of employee biological monitoring in that high-amplitude 24 h rhythms in biomarkers indicative of xenobiotic exposure may result in misjudgment of health risks when data are not gathered in sufficient frequency over time and properly interpreted. Biological reference values time-qualified for their rhythmic variation, currently of interest to laboratory medicine practice, are seemingly important to industrial medicine as circadian time and work-shift specific biological exposure indices to improve surveillance of personnel, particularly those working nonstandard shift schedules.

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Section: Chronotoxicologymentioning

confidence: 99%

Working Time Society consensus statements: Circadian time structure impacts vulnerability to xenobiotics—relevance to industrial toxicology and nonstandard work schedules

2019

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“…Especially in the evening between dinner and bed time, when the moderate daily dose of glucocorticoid is ingested or inhaled late in the day, the risk of adrenocortical suppression is increased [15]. known as Chronotherapy, which allows for appropriate dosing of actives at the most suitable times of the day, thus improving efficacy and reducing undesirable side effects [10,11].…”

Section: Chronotoxicologymentioning

confidence: 99%

Formulation and Evaluation of Misoprostal by Chronotherapeutic Drug Delivery System

Adeel¹,

Begum²,

Gouse³

et al. 2016

IJP

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“…Chronobiological variations have been reported to occur for mercury and cadmium (Cal et al 1985;Cambar and Pons 1994) in different species. Even for lead, blood and milk daily variations have been found (Valtorta et al 2003) in dairy cows receiving an intravenous injection of lead acetate at different hours after onset of light (HALO) in winter.…”

Section: Introductionmentioning

confidence: 99%

Daily rhythms in blood and milk lead toxicokinetics following intravenous administration of lead acetate to dairy cows in summer

et al. 2005

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The objective of this study was to investigate circadian variations of blood and milk lead toxicokinetics in dairy cows in summer. Twenty lactating Holstein animals were randomly assigned to four treatments corresponding to different hours after onset of light (HALO): 2, 8, 14, and 20. Cows received a single intravenous administration of 2.5 mg/kg lead as lead acetate. Blood and milk samples were taken and analyzed by atomic absorption spectrophotometry. For each toxicokinetic parameter, a one-way analysis of variance (ANOVA) was performed to outline the existence of daily variations. Significant blood differences as a function of HALO were found for the hybrid constant of distribution (alpha), hybrid constant of elimination (beta), elimination half-life (t(1/2)beta), area under the curve (AUC), volume of distribution at steady state (V(ss)) and clearance (Cl(B)) (p<0.05). Half-life of elimination presented two peaks at 2 and 14 HALO. Milk data showed significant differences for maximum concentration and AUC (p<0.05). The ratio AUC(milk)/AUC(blood) was utilized to estimate penetration of lead in milk. It differed significantly throughout the day (p<0.05). Milk data for the significant parameters could be fitted to circadian rhythms. No circadian rhythms were detected in blood parameters or in the ratio AUC(milk)/AUC(blood).

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New Trends in Chronotoxicology

Cited by 10 publications

References 45 publications

Working Time Society consensus statements: Circadian time structure impacts vulnerability to xenobiotics—relevance to industrial toxicology and nonstandard work schedules

Working Time Society consensus statements: Circadian time structure impacts vulnerability to xenobiotics—relevance to industrial toxicology and nonstandard work schedules

Formulation and Evaluation of Misoprostal by Chronotherapeutic Drug Delivery System

Daily rhythms in blood and milk lead toxicokinetics following intravenous administration of lead acetate to dairy cows in summer

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