New trends in the practical use of isoquinoline alkaloids as potential drugs applicated in infectious and non-infectious diseases

Tuzimski, Tomasz; Petruczynik, Anna

doi:10.1016/j.biopha.2023.115704

Cited by 12 publications

(4 citation statements)

References 144 publications

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“…They have been widely studied for their potential, not only antibacterial, but also antibiotic enhancers; furthermore, the effects of these compounds on virulence gene regulatory systems, such as quorum sensing and virulence factors, have also been reported [42][43][44]. Isoquinoline alkaloids of plant origin comprise a broad source of multimodal agents with unique structural diversity and a varied range of pharmacological activities [45], they are of great interest due to their promising biological activity [46], highlighting their antibacterial, antifungal, antiviral and antiparasitic activity, among others [47]. Likewise, studies reported by [48,49], have documented the antibacterial structure-activity relationship of isoquinoline alkaloids of the type protoberberine, protopine, benzophenanthridine, aporphine and bisbenzylisoquinoline, evidencing damage to the integrity of the membrane and cell wall, inhibition of efflux pumps and related enzymes, damage in bacterial DNA and protein synthesis, as mechanisms of antibacterial action of these compounds.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial and Antibiofilm Potential of Ethanolic Extracts of Duguetia vallicola (Annonaceae) against in-Hospital Isolates of Pseudomonas aeruginosa

Contreras-Martínez,

Sierra-Quiroz,

Angulo-Ortíz

2024

Preprint

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Pseudomonas aeruginosa is an opportunistic pathogen, especially dominant in people with cystic fibrosis; the drug resistance expressed by this pathogen and its capacity for adaptation generate a great challenge for its treatment and control, increasing morbidity and mortality rates globally. In this sense, the search for new treatment alternatives is imminent today, with products of plant origin being an excellent alternative to be used. The objective of this research was to evaluate the antibacterial and antibiofilm potential and to explore the possible effect of ethanolic extracts of wood and bark of Duguetia vallicola on the cell membrane. Microdilution assays showed inhibition of bacterial growth by more than 50%, with the lowest concentration evaluated (62.5μg/mL) of both extracts. Furthermore, we report the ability of both extracts to inhibit mature biofilms, with inhibition percentages between 48.4% and 93.7%. Intracellular material leakage experiments (260/280 nm), extracellular pH measurement, and fluorescence microscopy with acridine orange (AO) and ethidium bromide (EB) showed cell membrane damage. This indicates that the anti-bacterial action of ethanolic extracts of D. vallicola is associated with damage to the integrity of the cell membrane and consequent death of these pathogens. These results serve as a reference for future studies in establishing the mechanisms of action of these extracts.

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Section: Discussionmentioning

confidence: 99%

Antibacterial and Antibiofilm Potential of Ethanolic Extracts of Duguetia vallicola (Annonaceae) against in-Hospital Isolates of Pseudomonas aeruginosa

Contreras-Martínez,

Sierra-Quiroz,

Angulo-Ortíz

2024

Preprint

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“…Isoquinoline alkaloids of plant origin comprise a broad source of multimodal agents with unique structural diversity and a varied range of pharmacological activities [44]. They are of great interest due to their promising biological activity [45], highlighting their antibacterial, antifungal, antiviral, and antiparasitic activities, among others [46]. Likewise, previous studies [47,48] have documented the antibacterial structure-activity relationship of isoquinoline alkaloids of the protoberberine, protopine, benzophenanthridine, aporphine, and bisbenzylisoquinoline types, providing evidence of damage to membrane and cell wall integrity, inhibition of efflux pumps and related enzymes, as well as damage to bacterial DNA and protein synthesis, as mechanisms of antibacterial action of these compounds.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial and Antibiofilm Potential of Ethanolic Extracts of Duguetia vallicola (Annonaceae) against in-Hospital Isolates of Pseudomonas aeruginosa

Contreras-Martínez,

Sierra-Quiroz,

Angulo-Ortíz

2024

Plants

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Pseudomonas aeruginosa is an opportunistic pathogen that is especially dominant in people with cystic fibrosis; the drug resistance expressed by this pathogen and its capacity for adaptation poses a significant challenge to its treatment and control, thereby increasing morbidity and mortality rates globally. In this sense, the search for new treatment alternatives is imminent today, with products of plant origin being an excellent alternative for use. The objective of this research was to evaluate the antibacterial and antibiofilm potential and to explore the possible effect of ethanolic extracts from the wood and bark of Duguetia vallicola on the cell membrane. Microdilution assays showed the inhibition of bacterial growth by more than 50%, with the lowest concentration (62.5 μg/mL) of both extracts evaluated. Furthermore, we report the ability of both extracts to inhibit mature biofilms, with inhibition percentages between 48.4% and 93.7%. Intracellular material leakage experiments (260/280 nm), extracellular pH measurements, and fluorescence microscopy with acridine orange (AO) and ethidium bromide (EB) showed cell membrane damage. This indicates that the antibacterial action of ethanolic extracts of D. vallicola is associated with damage to the integrity of the cell membrane and consequent death of these pathogens. These results serve as a reference for future studies in establishing the mechanisms of action of these extracts.

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“…Some of the key secondary metabolites derived from mangrove endophytic fungi include alkaloids [7,8], terpenoids [9], polyketides [10,11], peptides [12,13], etc. Alkaloids constitute one of the largest categories among these secondary metabolites and have a wide range of biological activities, such as anticancer [14,15], anti-neurodegenerative [16], anti-diabetic [17], anti-inflammatory [18], and antimicrobial activities [19], among others. Exploiting new alkaloid natural products is of great importance for drug development.…”

Section: Introductionmentioning

confidence: 99%

Penifuranone A: A Novel Alkaloid from the Mangrove Endophytic Fungus Penicillium crustosum SCNU-F0006

Jia,

Wu,

Liu

et al. 2024

IJMS

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One previously undescribed alkaloid, named penifuranone A (1), and three known compounds (2–4) were isolated from the mangrove endophytic fungus Penicillium crustosum SCNU-F0006. The structure of the new alkaloid (1) was elucidated based on extensive spectroscopic data analysis and single-crystal X-ray diffraction analysis. Four natural isolates and one new synthetic derivative of penifuranone A, compound 1a, were screened for their antimicrobial, antioxidant, and anti-inflammatory activities. Bioassays revealed that penifuranone A (1) exhibited strong anti-inflammatory activity in vitro by inhibiting nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 cells with an IC50 value of 42.2 μM. The docking study revealed that compound 1 exhibited an ideal fit within the active site of the murine inducible nitric oxide synthase (iNOS), establishing characteristic hydrogen bonds.

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New trends in the practical use of isoquinoline alkaloids as potential drugs applicated in infectious and non-infectious diseases

Cited by 12 publications

References 144 publications

Antibacterial and Antibiofilm Potential of Ethanolic Extracts of Duguetia vallicola (Annonaceae) against in-Hospital Isolates of Pseudomonas aeruginosa

Antibacterial and Antibiofilm Potential of Ethanolic Extracts of Duguetia vallicola (Annonaceae) against in-Hospital Isolates of Pseudomonas aeruginosa

Antibacterial and Antibiofilm Potential of Ethanolic Extracts of Duguetia vallicola (Annonaceae) against in-Hospital Isolates of Pseudomonas aeruginosa

Penifuranone A: A Novel Alkaloid from the Mangrove Endophytic Fungus Penicillium crustosum SCNU-F0006

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