New Trends in Uric Acid Electroanalysis

Abstract

Considering the increasing incidence of hyperuricemia and oxidative stress-related diseases, quantification of uric acid has become essential. Therefore, the evolution on sensing devices being favorable, these questions are more often addressed to the field of medical researchers. As for many metabolites, (bio)sensors provide a reliable method for screening and evaluation of uric acid status. Due to the numerous categories of (bio)sensors available, choosing the appropriate one is a challenge. This study reviews the scientific information concerning the most suitable (bio)sensors for quantification of uric acid, presenting a list of sensors from the last decade, categorized by configurations and materials. In addition, this review includes a comparison of sensors according to their interference behavior and sensitivity, offering an objective perspective for identifying devices that are suitable for clinical applications.

Palladium-Coated Submicron Electrospun Polymeric Fibers with Immobilized Uricase for Uric Acid Determination in Body Fluids

“…Recently, flexible electrochemical sensors and biosensors have been developed for wearable sensing platforms targeting different biological fluids, such as tears, interstitial fluids, urine, breath, and sweat . These can be constructed employing nanostructured materials, which aid in further miniaturization due to their enhanced charge transfer kinetics, high surface-to-volume ratios and facile functionalization, manipulation, and processing. − Most of the examples found in the literature report the integration of metallic nanoparticles (Au, Ag,) and carbon nanomaterials (MWCNT, GO, CNF) within flexible substrates (PET, cotton yarn) as transductors . However, the sensitivity and selectivity of these devices remain below the performance thresholds for clinical applications.…”