New trial of progestin-primed ovarian stimulation using dydrogesterone versus a typical GnRH antagonist regimen in assisted reproductive technology

Iwami, Nanako; Kawamata, Miho; Ozawa, Naoko; Yamamoto, Takahiro; Watanabe, Eri; Moriwaka, Osamu; Kamiya, Hirobumi

doi:10.1007/s00404-018-4856-8

Cited by 51 publications

(51 citation statements)

References 37 publications

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“…15,30,31 Iwami et al compared the antagonist protocol and PPOS and obtained similar results in normo-responsive patients. 15 Begueria et al performed a non-inferiority trial to compare MPA and GnRH antagonist with regard to the number of mature oocytes retrieved in oocyte donation cycles, and reported no differences in the number of mature oocytes, length of stimulation, fertilization rate, or quality of embryos between the two treatments. 30 Although pregnancy rates were lower in the MPA group, live birth rates were similar between the two groups.…”

Section: Discussionmentioning

confidence: 89%

“…It has shown efficacy in normo-responsive patients. 15,16,20 Daily administration of 20 mg DYD was shown to have similar effects to natural progesterone. 16 In comparison with MPA for PPOS, DYD showed similar clinical pregnancy rates, but GnRH suppression was weaker in the DYD group.…”

Section: Discussionmentioning

confidence: 99%

“…14 Subsequent studies confirmed the blocking effect of progesterone on LH elevation during ovarian stimulation, with optimal pregnancy outcomes in FET cycles. [12][13][14][15][16] The requirement for the freeze-all strategy in the PPOS protocol due to endometrium desynchronization seems to be a disadvantage. However, PPOS may be the best option for conditions in which fresh embryo transfer is not appropriate, such as donor cycles, preimplantation genetic testing cycles, fertility preservation, and hyper-responsive patients with high risk of OHSS.…”

Section: Introductionmentioning

confidence: 99%

“…However, DYD was better tolerated, had fewer adverse effects and was more stable for follow-up of blood hormone levels than natural progesterone. 15 Huang and Eftekhar showed that the application of DYG in PPOS protocol could achieve comparable oocyte retrieval and pregnancy outcomes in two different studies. 22,23 Therefore, in the present study, we compared the efficacy of DYD and the GnRH antagonist cetrorelix (CET) in the prevention of LH peak in hyper-responsive patients undergoing freeze-all IVF.…”

Section: Introductionmentioning

confidence: 99%

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Dydrogesterone‐primed ovarian stimulation is an effective alternative to gonadotropin‐releasing hormone antagonist protocol for freeze‐all cycles in polycystic ovary syndrome

Gürbüz

Göde

2020

J of Obstet and Gynaecol

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Objective To compare the effects of progestin‐primed ovarian stimulation using dydrogesterone (DYD) and a gonadotropin‐releasing hormone (GnRH) antagonist protocol on cycle characteristics and pregnancy rates in freeze‐all cycles in patients with polycystic ovary syndrome (PCOS). Methods Medical records of PCOS patients who underwent freeze‐all in vitro fertilization cycles between April 2017 and April 2019 at the Novafertil in vitro fertilization Center were retrospectively evaluated. The primary outcome measure was the incidence of premature luteinizing hormone surge. Secondary outcome measures were the total number of mature oocytes retrieved, fertilization rate, clinical pregnancy rates and ongoing pregnancy rates. Results: A total of 525 patients were included in the study. DYD‐primed ovarian stimulation and a GnRH antagonist protocol were applied in 258 and 267 patients, respectively. The baseline parameters were similar between the two groups. The numbers of mature and fertilized oocytes were similar in the cetrorelix (CET) group and DYD group (11.43 ± 3.48 vs. 11.29 ± 4.34, respectively, P = 0.692; and 8.98 ± 2.93 vs. 8.62 ± 3.67, respectively, P = 0.208). Premature luteinization was rare in both groups, and the difference between the groups was not statistically significant (2.9% vs. 1.5%, respectively, P = 0.268). There was no significant difference in clinical pregnancy rate of the first frozen embryo transfer cycle between the DYG group and the CET group (56% [120/214] vs. 55.6% [113/203], respectively, P = 0.283). There were no significant differences in biochemical pregnancy rates, implantation rates, miscarriage rates or ongoing pregnancy rates between the two groups (P > 0.05). Conclusion Dydrogesterone‐primed ovarian stimulation seems to be an effective alternative to the GnRH antagonist protocol for freeze‐all cycles in PCOS patients.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dydrogesterone‐primed ovarian stimulation is an effective alternative to gonadotropin‐releasing hormone antagonist protocol for freeze‐all cycles in polycystic ovary syndrome

Gürbüz

Göde

2020

J of Obstet and Gynaecol

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“…1 Recently, the use of dydrogesterone with the same purpose was also effective in preventing the premature LH surge. 3 However, other types of progesterone have not been tested. Desogestrel is a progesterone that is broadly known and accepted in the context of contraception and that has good tolerability and low cost.…”

Section: Introductionmentioning

confidence: 99%

Desogestrel for preventing a premature luteinizing hormone (LH) surge in a cycle for oocyte cryopreservation

Bessow¹,

Donato²,

Filho³

2018

Hum. Reprod. Arch.

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Objectives:The advance of cryopreservation techniques turn possible the use of new strategies for LH supression during in vitro fertilization (IVF) cycles. Methods: The use of progesterone instead of gonadotropin-releasing hormone (GnRH) analogues seems to be a feasible option. Desogestrel is a progesterone broadly known and accepted in the context of contraception, with a good tolerability and low cost, in addition to a potent anti-ovulatory potency. Results: The present case is the first describing a succesfully controlled ovarian hyperstimulation (COH) for social oocyte cryopreservation using desogestrel 75mcg as a LH blocker in a healthy 35-year-old woman. Conclusions: the use of progesterone for LH supression seems to be a great option in the context of oocyte cryopreservation, since it is safe, less expensive and patient-friendly, avoiding the daily injections of GnRH analogues.

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Progestogens for prevention of luteinising hormone (LH) surge in women undergoing controlled ovarian hyperstimulation as part of an assisted reproductive technology (ART) cycle

Glujovsky,

Pesce,

Miguens

et al. 2023

Cochrane Database of Systematic Reviews

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New trial of progestin-primed ovarian stimulation using dydrogesterone versus a typical GnRH antagonist regimen in assisted reproductive technology

Abstract: The clinical and ongoing pregnancy rates in study group were comparable to those in control group. Therefore, PPOS with dydrogesterone is a reasonable option to provide COH.

Cited by 51 publications

References 37 publications

Dydrogesterone‐primed ovarian stimulation is an effective alternative to gonadotropin‐releasing hormone antagonist protocol for freeze‐all cycles in polycystic ovary syndrome

Dydrogesterone‐primed ovarian stimulation is an effective alternative to gonadotropin‐releasing hormone antagonist protocol for freeze‐all cycles in polycystic ovary syndrome

Desogestrel for preventing a premature luteinizing hormone (LH) surge in a cycle for oocyte cryopreservation

Progestogens for prevention of luteinising hormone (LH) surge in women undergoing controlled ovarian hyperstimulation as part of an assisted reproductive technology (ART) cycle

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