New triazenoimidazoles

Antitumor activity of imidazole derivatives: dacarbazine and the new alkylating agent imidazene (Review)

“…Dacarbazine derivatives with cyano- [28,29], iminoester, or amidine groups [30] in the imidazole 4-position are known. R = CH 3 , C 2 H 5 , CH 2 CH 2 CI, CH 2 CH 2 F, 2-hydroxynaphthyl, (CH 3 ) 2 NC 6 H 4 ;…”

“…The antitumor properties of the cyano derivatives against L 1210 [28] and of the amidines against melanoma B 16 , Ca 755, and leukemia La [30] were studied. The antitumor activity of the methylamidine was substantially below that of dacarbazine whereas the toxicity was greater.…”