New tricks of old drugs: Repurposing non-chemo drugs and dietary phytochemicals as adjuvants in anti-tumor therapies

Zhang, Mei; Chen, Xianfeng; Radacsi, Norbert

doi:10.1016/j.jconrel.2020.11.047

Cited by 24 publications

(15 citation statements)

References 299 publications

(331 reference statements)

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“…Therefore, a combinatorial approach of these compounds with conventional chemotherapeutics may achieve a synergistic effect that increases toxicity in cancer cells (associated to the sensitization of the cancer cells to the drugs, attributed to the phytochemicals), reduces therapeutic doses and also toxicity concerns [214,217,218]. In this sense, numerous studies have evaluated the efficiency of this combination and have been compiled extensively in recent reviews [116,219]. For example, resveratrol has been successfully used as adjuvant of several conventional chemotherapeutic drugs, such as temozolomide, doxorubicin and paclitaxel on in vitro assays and mice models [114][115][116].…”

Section: Combination Of Phytochemicals With Conventional Chemotherapementioning

confidence: 99%

Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment

et al. 2021

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Nowadays, cancer is one of the deadliest diseases in the world, which has been estimated to cause 9.9 million deaths in 2020. Conventional treatments for cancer commonly involve mono-chemotherapy or a combination of radiotherapy and mono-chemotherapy. However, the negative side effects of these approaches have been extensively reported and have prompted the search of new therapeutic drugs. In this context, scientific community started to look for innovative sources of anticancer compounds in natural sources, including traditional plants. Currently, numerous studies have evaluated the anticancer properties of natural compounds derived from plants, both in vitro and in vivo. In pre-clinical stages, some promising compounds could be mentioned, such as the sulforaphane or different phenolic compounds. On the other hand, some phytochemicals obtained positive results in clinical stages and were further approved for cancer treatment, such as vinca alkaloids or the paclitaxel. Nevertheless, these compounds are not exempt of limitations, such as low solubility, restricted effect on their own, negative side-effects, etc. This review aims to compile the information about the current phytochemicals used for cancer treatment and also promising candidates, main action mechanisms and also reported limitations. In this sense, some strategies to face the limitations have been considered, such as nano-based formulations to improve solubility or chemical modification to reduce toxicity. In conclusion, although more research is still necessary to develop more efficient and safe phytochemical drugs, more of these compounds might be used in future cancer therapies.

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Section: Combination Of Phytochemicals With Conventional Chemotherapementioning

confidence: 99%

Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment

et al. 2021

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“…It is important to note that an efficient therapeutic approach is based on the accumulation of drugs and phytochemicals in the cancer site; in addition, the low bioavailability of the anticancer compounds may hinder their sufficient accumulation. For most natural molecules obtained from the diet, the hydrophobicity and the short half-life can lead to low bioavailability, reducing the efficiency of the therapies [163]. Noteworthy, it should be taken into account that many natural compounds may modulate the activity of CYP450, which is involved in the metabolism of several drugs and compounds [164].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…In order to solve this problem, biopolymeric nanoparticles and micelles have been used for obtaining an efficient co-delivery of drugs and phytochemicals [165]. In order to obtain the precise release of drugs specifically targeting the tumor sites, several strategies have been developed: from hydrogels to polymeric prodrugs and micelles able to self-assemble, with promising perspectives both in in vitro and in vivo cancer models [163]. Importantly, being versatile carriers for many chemotherapeutics and natural molecules, liposomes have been used to perform the co-delivery of phytochemicals and repurposed drugs in combination with anti-tumor therapeutics [163].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…In order to obtain the precise release of drugs specifically targeting the tumor sites, several strategies have been developed: from hydrogels to polymeric prodrugs and micelles able to self-assemble, with promising perspectives both in in vitro and in vivo cancer models [163]. Importantly, being versatile carriers for many chemotherapeutics and natural molecules, liposomes have been used to perform the co-delivery of phytochemicals and repurposed drugs in combination with anti-tumor therapeutics [163]. Interestingly, inorganic materials, like mesoporous silica nanoparticles, have been used as carriers for the delivery of conventional antitumor drugs, repurposed drugs and natural compounds [166].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Gastrointestinal Tumors: Phytochemical and Drug Combinations Targeting the Hallmarks of Cancer

2021

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Cancer is a worldwide burden resulting in millions of deaths each year. In particular, gastrointestinal tumors are life-threatening malignancies and one of the leading reasons for death in developed countries. Phytochemicals can be found in grains, vegetables, fruits and several foods. Many phytochemicals, such as curcumin, genistein, luteolin, vitexin-2-O-xyloside, avenanthramides, quercetin, epigallocatechin-3-gallate (EGCG), resveratrol, sulforaphane, piperine and thymoquinone have been used in combination with different chemotherapeutic agents for their synergistic anticancer effects against various forms of cancer. In this review, we describe the antitumor properties and biological effects of combinations of phytochemicals and anticancer drugs against gastrointestinal tumors: colon cancer, gastric cancer, liver cancer, pancreatic cancer. We focus on the molecular pathways, oncoproteins and tumor suppressors modulated by the combination of phytochemicals with antitumor drugs and on the biomarkers of the hallmarks of cancer influenced by these therapeutic strategies in cancer cell lines, xenograft models and clinical trials. The increased knowledge of biomarkers and molecular pathways regulated by the combination of phytochemicals and conventional anticancer drugs in both in vitro and in vivo models will remarkably improve the efficacy of these therapeutic strategies against gastrointestinal tumors in future innovative clinical applications.

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“…In recent years, drug delivery systems have attracted widespread attention due to their ability to deliver the correct number of drugs to the proper place [ 1 , 2 , 3 , 4 , 5 ], especially for poorly soluble drugs. More than two-thirds of promising drugs on the market have limited biomedical functions due to dissolution problems [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Coaxial Fibers to Optimize the Release of Poorly Water-Soluble Drug

et al. 2022

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In a drug delivery system, the physicochemical properties of the polymeric matrix have a positive impact on the bioavailability of poorly water-soluble drugs. In this work, monolithic F1 fibers and coaxial F2 fibers were successfully prepared using polyvinylpyrrolidone as the main polymer matrix for drug loading and the poorly water-soluble curcumin (Cur) as a model drug. The hydrophobic poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV) was designed as a blank layer to change the hydrophilicity of the fiber and restrain the drug dissolution rate. The curved linear morphology without beads of F1 fibers and the straight linear morphology with few spindles of F2 fibers were characterized using field-emission environmental scanning electron microscopy. The amorphous forms of the drug and its good compatibility with polymeric matrix were verified by X-ray diffraction and attenuated total reflectance Fourier transformed infrared spectroscopy. Surface wettability and drug dissolution data showed that the weaker hydrophilicity F2 fibers (31.42° ± 3.07°) had 24 h for Cur dissolution, which was much longer than the better hydrophilic F1 fibers (15.31° ± 2.79°) that dissolved the drug in 4 h.

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New tricks of old drugs: Repurposing non-chemo drugs and dietary phytochemicals as adjuvants in anti-tumor therapies

Cited by 24 publications

References 299 publications

Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment

Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment

Gastrointestinal Tumors: Phytochemical and Drug Combinations Targeting the Hallmarks of Cancer

Electrospun Coaxial Fibers to Optimize the Release of Poorly Water-Soluble Drug

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