New Triheterocyclic Ring System. Synthesis of Functionalized Pyrazolo[3,4‐d]Pyrimido[1,2‐b][1,2,4,5]Tetrazine Derivatives

Mosselhi, Mosselhi A. N.; Hussein, Ahmad M.; Shawali, Ahmad S.

doi:10.1002/jccs.200600123

Cited by 5 publications

(1 citation statement)

References 15 publications

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“…In continuation of our studies dealing with the utility of hydrazonoyl halides for synthesis of various heterocyclic ring systems, [1][2][3][4][5][6][7][8][9][10][11] we wish to report herein a new facile synthesis of bispyrazolo [1,5-a][4',3'-e]pyrimidine ring system and its various functionalized derivatives that have not been reported hitherto. The earlier methods reported for synthesis of such ring system are multisteps.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of a new triheterocycle. Bis-pyrazolo[1,5-a][4',3'-e]pyrimidine

Shawali¹,

Tawfik²

2009

Arkivoc

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Starting from 2,7-dimethyl-8-phenylazo-4(6H)-pyrazolo[1,5-a]-pyrimidinone 1, a series of functionalized derivatives of the title tricyclic system 4 have been synthesized via its reaction with various hydrazonoyl halides 2 and cyclization of the resulting substitution products 3. The mechanism and the site selectivity of the reactions studied are discussed. The structures of the compounds 3 and 4 isolated were elucidated on the basis of their spectra, elemental analyses and alternate synthesis.

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Section: Introductionmentioning

confidence: 99%

Synthesis of a new triheterocycle. Bis-pyrazolo[1,5-a][4',3'-e]pyrimidine

Shawali¹,

Tawfik²

2009

Arkivoc

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Novel facile synthesis of imidazo[1,2-b]-[1,2,4,5]tetrazines with potential antimicrobial activity

Shawali

Tawfik

2009

Arch. Pharm. Res.

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Starting from 1-amino-2-methylthio-4-phenylimidazole 2, a series of the title compounds have been synthesized via its reactions with various hydrazonoyl halides 3. The mechanism of the reactions studied is discussed. The structure of the compounds prepared were elucidated on the basis of their elemental analyses, spectral data and alternate synthesis. The antimicrobial activities of the compounds prepared were screened and the results showed that most of such compounds exhibit considerable activities.

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