New trinuclear nickel(II) complexes as potential topoisomerase I/IIα inhibitors: in vitro DNA binding, cleavage and cytotoxicity against human cancer cell lines

Nano-crystallites of a ruthenium(iii) violurate complex: synthesis, characterization, PXRD and DFT structural analysis. DNA/HSA-binding, antiviral activity against COVID-19 and molecular docking study

“…69,70 Regarding violuric acid, the recorded spectral properties are comparable with other DNA-binders of the groove/electrostatic binding mode. 71…”

“…This spectral profile indicates the intercalation bonding pattern and excludes non-covalent bonding or groove/electrostatic bonding. 71 The data obtained are represented graphically as shown in S19 (ESI†) and Fig. 7 for violuric acid and the Ru( iii ) complex, respectively, where the slope-to-intercept ratio gives the value of k b .…”

“…69,70 Regarding violuric acid, the recorded spectral properties are comparable with other DNA-binders of the groove/electrostatic binding mode. 71 The intrinsic binding constant (k b ) is a reliable quantitative indicator to measure the degree to which the compounds under study bind to a biomolecule such as DNA. Based on the obtained results of spectrophotometric titrations, k b can be graphically determined according the Benesi-Hildebrand relationship: 72 and higher than reported for other ruthenium complexes.…”

Synthesis, Structural Investigations, DNA/BSA Interactions, Molecular Docking Studies, and Anticancer Activity of a New 1,4-Disubstituted 1,2,3-Triazole Derivative

“…The DNA binding activity of the compound was investigated using UV−vis and fluorescence spectral studies in accordance with our previous studies. 59,82 All titrations were performed in 10 mM Tris-HCl buffer with a pH of 7.4 at room temperature. The UV−vis absorption studies were performed by adding increasing amounts of DNA (0−100 μM) to a solution of a fixed concentration (50 μM) of the compound.…”

“…The DNA binding activity of the compound was investigated using UV–vis and fluorescence spectral studies in accordance with our previous studies. 59 , 82 …”