New triterpene saponins from the roots of Acacia macrostachya (Mimosaceae)

Abstract

Four new oleanane-type saponins, macrostachyaosides A, B, C, and D (1-4) were isolated from the roots of Acacia macrostachya. Their structures were elucidated on the basis of extensive 1D- and 2D-NMR data and HR-ESI-MS analyses. At concentrations of 100 μM of each compounds, none of the tested compounds caused a significant growth reduction against HL60 cells.

Inventory of human-edible products from native Acacia sensu lato in Africa, America, and Asia: Spotlight on Senegalia seeds, overlooked wild legumes in the arid tropics

“…Acacia s.l. plant foods are likely interesting sources of new biologically active phytochemicals from these groups (i.e., cardiac glycosides, steroids, alkaloids, and saponins) (Kim et al, 2015;Lomarat et al, 2015;Rifai et al, 2010;Ruangsuriya et al, 2022;Tchoukoua et al, 2017Tchoukoua et al, , 2018Tezuka et al, 2000). Lectin activity, for instance, is rarely detected, and the reports (Balogun & Fetuga, 1989;Hapner & Jermyn, 1981;Lee et al, 1977;Rajaram & Janardhanan, 1991) present discrepancies, suggesting that Senegalia seeds have minor lectins or hemagglutination inhibitors (Hapner & Jermyn, 1981).…”

“…Acacia s.l. plant foods are likely potential sources of new biologically active phytochemicals (Kim et al, 2015;Lomarat et al, 2015;Rifai et al, 2010;Ruangsuriya et al, 2022;Tchoukoua et al, 2017Tchoukoua et al, , 2018Tezuka et al, 2000). Further research is needed to profile the phytochemicals from Acacia s.l.…”

Phytochemical Screening and Antioxidant and Cytotoxic Effects of Acacia macrostachya

“…Of note, investigations of leaf, stem, and root bark extracts of A. macrostachya revealed the presence of secondary metabolites, such as saponins, flavonoids, tannins, and alkaloid salts [ 13 , 15 ]. Furthermore, qualitative analyses of methanol extracts from the roots of this plant revealed the presence of triterpenes, steroids, and tannins [ 2 , 16 ]. The presence of these secondary metabolites could justify the antioxidant and anticancer properties [ 2 ] of this plant.…”

Antibacterial, Antibiofilm, and Efflux Pump Inhibitory Properties of the Crude Extract and Fractions from Acacia macrostachya Stem Bark

“…Previous biological activity studies have confirmed the anticancer [ 10 ], antidiabetic [ 11 ], antioxidant [ 12 ], anti-inflammatory, analgesic [ 13 ], antiplasmodial, [ 14 ] and antibacterial [ 15 ] activities of different parts of A. macrostachya . Other works report the presence of oleanane triterpene saponins in the roots as well as phenolic acids and flavonoids with antioxidant activity in the leafy stems [ 15 , 16 ]. In a continuing effort to investigate the bioactivities of tropical medicinal plants [ 17 , 18 ], the antibacterial, antibiofilm, and efflux pump inhibition activities of the stem of A. macrostachya (Leguminoseae) were studied.…”