New triterpene sulfates from Vietnamese red alga <i>Tricleocarpa fragilis</i> and their α-glucosidase inhibitory activity

Anh, Trần Thị Vân; Nguyễn, Văn Minh; Nhung, Nguyen Thi Ai; Nguyen, Duy–Cuong; Tran, Duy Hien; Bui, Thi Phuong Thuy; Pham, Van Tat

doi:10.1080/10286020.2020.1783658

Cited by 5 publications

(1 citation statement)

References 15 publications

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“…Four steroids, 3β-methyl-25-dihydroxycycloart-23-en-29-oate 3-sulfate (12), 3β-methylhydroxy-25-methoxycycloart-23-en-29-oate 3-sulfate (13), 3β-hydroxy-25-methoxycycloart-23-ene 3-sulfate (14) and (3β-hydroxycycloart-24-en-23-one 3-sulfate (15) were isolated from Vietnamese red alga Tricleocarpa fragilis. All isolated steroids showed potent inhibitory activity against yeast α-glucosidase with IC 50 values of 16.6, 36.3, 30.2 and 6.5 µM, respectively [67]. The Far Eastern sea cucumber Eupentacta fraudatrix (Class Holothuroidea) are sedentary and feed on plankton, algae, and organic debris extracted from bottom silt and sand that is passed through the alimentary canal.…”

Section: Cyclopropane Containing Steroids and Triterpenoidsmentioning

confidence: 99%

Antitumor Profile of Carbon-Bridged Steroids (CBS) and Triterpenoids

2021

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This review focuses on the rare group of carbon-bridged steroids (CBS) and triterpenoids found in various natural sources such as green, yellow-green, and red algae, marine sponges, soft corals, ascidians, starfish, and other marine invertebrates. In addition, this group of rare lipids is found in amoebas, fungi, fungal endophytes, and plants. For convenience, the presented CBS and triterpenoids are divided into four groups, which include: (a) CBS and triterpenoids containing a cyclopropane group; (b) CBS and triterpenoids with cyclopropane ring in the side chain; (c) CBS and triterpenoids containing a cyclobutane group; (d) CBS and triterpenoids containing cyclopentane, cyclohexane or cycloheptane moieties. For the comparative characterization of the antitumor profile, we have added several semi- and synthetic CBS and triterpenoids, with various additional rings, to identify possible promising sources for pharmacologists and the pharmaceutical industry. About 300 CBS and triterpenoids are presented in this review, which demonstrate a wide range of biological activities, but the most pronounced antitumor profile. The review summarizes biological activities both determined experimentally and estimated using the well-known PASS software. According to the data obtained, two-thirds of CBS and triterpenoids show moderate activity levels with a confidence level of 70 to 90%; however, one third of these lipids demonstrate strong antitumor activity with a confidence level exceeding 90%. Several CBS and triterpenoids, from different lipid groups, demonstrate selective action on different types of tumor cells such as renal cancer, sarcoma, pancreatic cancer, prostate cancer, lymphocytic leukemia, myeloid leukemia, liver cancer, and genitourinary cancer with varying degrees of confidence. In addition, the review presents graphical images of the antitumor profile of both individual CBS and triterpenoids groups and individual compounds.

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Section: Cyclopropane Containing Steroids and Triterpenoidsmentioning

confidence: 99%