New Triterpenes from <i>Gymnema sylvestre</i>

Zarrelli, Armando; DellaGreca, Marina; Ladhari, Afef; Haouala, Rabiaa; Previtera, Lucio

doi:10.1002/hlca.201200331

Cited by 17 publications

(7 citation statements)

References 13 publications

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“…The CH 2 Cl 2 extract showed the highest DPPH· and OH scavenging activities and from its investigation we have isolated thirteen triterpenes (1-13, Figure 1) [15]. …”

Section: Resultsmentioning

confidence: 99%

Scavenging Effect of Various Extracts of the Gymnema sylvestre R. Br. and Antioxidant Activity of the Isolated Triterpenes

Romanucci¹,

Piero²,

Marino³

et al. 2017

Rec. Nat. Prod.

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Gymnema sylvestre has been used in Asian traditional medicine for its anti-microbial, antihypercholesterolemic, hepatoprotective and sweet suppressing properties and activities. G. sylvestre has also been used extensively in chewing gum, as a health food for preventing obesity and diabetes, and as a tea. This study has evaluated the total phenolic content and antioxidant activity of the aqueous and organic G. sylvestre extracts and their sub-fractions for the initial characterization of the biological properties of the isolated compounds. An in vivo cell model was used to calculate the concentration inhibiting cell growth by 50% and the ability to exert antioxidant activity. All compounds inhibit cell growth in a dose-dependent manner, with an IC 50 value ranging between 29 and 1462 μM. The effects on intracellular ROS levels are extremely variable, but it is of interest that some of the compounds appear to display an antioxidant effect.

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“…The CH 2 Cl 2 extract showed the highest DPPH· and OH scavenging activities and from its investigation we have isolated thirteen triterpenes (1-13, Figure 1) [15]. …”

Section: Resultsmentioning

confidence: 99%

Scavenging Effect of Various Extracts of the Gymnema sylvestre R. Br. and Antioxidant Activity of the Isolated Triterpenes

Romanucci¹,

Piero²,

Marino³

et al. 2017

Rec. Nat. Prod.

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“…Not surprisingly, this plant has been and is still being studied by many research groups, as demonstrated by the publication of thousands of articles and the isolation of one hundred new and known molecules. However, few of the oleane triterpenoids isolated from GS that are gem-dimethylated at C-4 (see Figure 1 and Table 3 and Table 4 [80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95], Table 5 [89,95,96,97,98,99,100,101,102,103,104,105], Table 6 [81,82,83,88,89,91,92,93,94,95,103], Table 7 [51,89,95,99,100,104,105,106,107,108,109]) have been assayed (see Figure 1 and Table 8 [81,82,88,89,...…”

Section: Discussion Of the Specific Biological Activity Of Tested mentioning

confidence: 99%

C-4 Gem-Dimethylated Oleanes of Gymnema sylvestre and Their Pharmacological Activities

et al. 2013

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Gymnema sylvestre R. Br., one of the most important medicinal plants of the Asclepiadaceae family, is a herb distributed throughout the World, predominantly in tropical countries. The plant, widely used for the treatment of diabetes and as a diuretic in Indian proprietary medicines, possesses beneficial digestive, anti-inflammatory, hypoglycemic and anti-helmentic effects. Furthermore, it is believed to be useful in the treatment of dyspepsia, constipation, jaundice, hemorrhoids, cardiopathy, asthma, bronchitis and leucoderma. A literature survey revealed that some other notable pharmacological activities of the plant such as anti-obesity, hypolipidemic, antimicrobial, free radical scavenging and anti-inflammatory properties have been proven too. This paper aims to summarize the chemical and pharmacological reports on a large group of C-4 gem-dimethylated pentacyclic triterpenoids from Gymnema sylvestre.

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“…The chemical components of G. sylvestre have been confirmed the presence of pregnane glycosides, [1] gymnemic acid glycosides, [2] and oleanane saponins. [3,4] Herein, we reported the isolation and structural elucidation of three pregane-type triterpene glycosides from the leaves of G. sylvestre (figure 1).…”

Section: Introductionmentioning

confidence: 99%