New type of RNA virus replication inhibitor based on decahydro-closo-decaborate anion containing amino acid ester pendant group

Recent Achievements on Functionalization within closo‐Decahydrodecaborate [B10H10]2− Clusters

“… [50] Oxygen derivatives of decaborate are considered as crucial precursors for the proper integration of decaborate within medicine, for instance, Avdeeva et al . recently reported the synthesis of an RNA virus replication inhibitor based on the decahydro‐closo‐decaborate anion [51] . The authors conceptualized the use of the decaborate anion as an inorganic membranotropic carrier instead of organic adamantane and effectuated the synthesis starting from the protonation of [B 10 H 10 ] 2− anion in the CH 3 CN/CF 3 COOH to yield [B 10 H 11 ] − anion which was converted to the O‐substituted derivative [2‐B 10 H 9 O(C 4 H 8 )] − .…”

“…[50] Oxygen derivatives of decaborate are considered as crucial precursors for the proper integration of decaborate within medicine, for instance, Avdeeva et al recently reported the synthesis of an RNA virus replication inhibitor based on the decahydro-closo-decaborate anion. [51] The authors conceptualized the use of the decaborate anion as an inorganic membranotropic carrier instead of organic adamantane and effectuated the synthesis starting from the protonation of [B 10 Another indirect approach has been established via an oxygen linker. Synthesis of carboxonium derivatives of closodecaborate anion was recently reported; (PPh 4 ) [B 10 H 11 ] and carboxylic acids was heated for 1 h at 120 °C under continuous stirring and inert atmosphere.…”

Multistep synthesis and X-ray structures of carboxyl-terminated hybrid iron(ii) phthalocyaninatoclathrochelates and their postsynthetic transformation into polytopic carboranyl-containing derivatives

“…They are widely used in radiotherapy of several cancer diseases, being the prospective boron-enriched targeting compounds for 10-Boron Neutron Capture Therapy ( 10 B-NCT) treatment. 16 b Moreover, very recently, one of the closo -borate clusters, functionalized with a biorelevant amino acid residue, was found 17 to possess a strong antiviral activity against the modern strains of A/H1N1 virus. On the other hand, it is inactive against SARS-CoV-2 virus, thus suggesting its specific activity against RNA virus replication.…”

Molecular Docking Studies of Boron‐Containing Compounds as Dual Inhibitors of SARS‐Cov‐2 Spike Receptor Binding Domain/ACE2 Complex and Main Protease and ADMET Investigations

“…Bortezomib and other boron-containing peptidomimetics, [33,34,35,36] boron nitride (BN) oxide nanosheets, [31] new generation of boron-doped or boron attached composite quantum dots (QDs), [30] combination of 2aminoethyl diphenyl borate with curcumin, [32] dioxaborole compounds, [29] boron-containing nanocages, [37] boron citrate and oleoylethanolamide, [38] biosensors (boron-doped), [39,40,41,42] boron nitride nanosheets (BNNS), [43] 10-vertex boron cage [44] and cobalt (III)-containing BÀ N cluster complexes. [45] The druggability properties of chemical compounds substantially depends on their ADMET properties where ADMET refers to adsorption, distribution, metabolism, extraction and toxicity of molecules.…”

“…Boron‐containing compounds (BCCs) are attractive chemicals, some of which reported as COVID‐19 protease inhibitors in the literature. Some of these are: Bortezomib and other boron‐containing peptidomimetics, [33,34,35,36] boron nitride (BN) oxide nanosheets, [31] new generation of boron‐doped or boron attached composite quantum dots (QDs), [30] combination of 2‐aminoethyl diphenyl borate with curcumin, [32] dioxaborole compounds, [29] boron‐containing nanocages, [37] boron citrate and oleoylethanolamide, [38] biosensors (boron‐doped), [39,40,41,42] boron nitride nanosheets (BNNS), [43] 10‐vertex boron cage [44] and cobalt (III)‐containing B−N cluster complexes [45] …”