New uses of ketoprofen – a review of studies from 2015 to 2021

Abstract

Ketoprofen (K) belongs to the family of nonsteroidal anti-inflammatory drugs (NSAIDs) and demonstrates analgesic, anti-inflammatory and antipyretic properties. K is one of the most commonly used NSAIDs because of the speed and effectiveness of its activity. K is currently used for the treatment of pain and treatment of symptoms in rheumatic diseases, however, many researchers are looking for new uses of K. The aim of the review was to present the possible applications of K as indicated in current literature. We searched research literature and compiled all the reports (2015 onwards) we could find about new possible employments of K in health practices. Many studies have been aimed at obtaining new uses of K. This article describes the use of ketoprofen lysine salt for treating injured gastric mucosa, the anti-allergic potential of K, the employment of K in treating nonalcoholic fatty liver disease, human lymphedema and seizures, as well as the antidepressant and anxiolytic effects of K, prospects for the use of K in oncology and transplantology. The findings of the review confirm that K, its derivatives and complexes have many newly discovered effects. It is likely that in the future, K will have more indications than it has today.

Synthesis and Biological Studies of Cationic Organoiron Star-Shaped Dendrimers with Attached Ketoprofen and Mefenamic Acid at the Peripheries

“…[44][45][46][47] Since their approval in the late 1900s, ketoprofen and mefenamic acid have been commonly used oral or topical NSAIDs that have been used clinically for their anti-inflammatory properties. [45,48,49] Like other drugs in the NSAID family, ketoprofen and mefenamic acid reduce inflammation by blocking cyclooxygenase (both COX-1 and COX-2), an enzyme responsible for produce a messenger in the development of inflammation known as prostaglandins. [45] The specific NSAIDs have been used to help with muscle pain, headaches, and menstrual cramps (dysmenorrhea).…”

FT-IR Analysis of Structural Changes in Ketoprofen Lysine Salt and KiOil Caused by a Pulsed Magnetic Field

“…The influences of external agents on biological systems and on pharmacological molecules can cause changes in their pharmacological properties (intensity, frequency, etc.). The synthesis of drugs with specific polymorphisms (e.g., carbamazepine, indomethacin, and paracetamol) results in unique properties, and thus external physical factors can affect their biological effects [ 20 ].…”

“…The aim of the study is to determine the effect of a high-intensity low-frequency pulsed MF on the spectroscopic characteristics of topical drugs, specifically on ketoprofen lysine salt (which belongs to the propionic acid derivative family) and KiOil (a patented nutraceutical product) [ 20 ]. Since morphological and functional changes in exposed molecules can have a clinical impact if used during a treatment, a clinical study on 22 patients with lower back pain was managed with the same MF therapy plus topical ketoprofen or topical KiOil.…”