New Uses of Melatonin as a Drug; A Review

Pohanka, Miroslav

doi:10.2174/0929867329666220105115755

Cited by 16 publications

(6 citation statements)

References 163 publications

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“…Sleep is regulated by circadian and homeostatic processes ( Saper et al, 2005 ; Borbély, 2022 ). Melatonin (N-acetyl-5-methoxytryptamine) is an endogenous hormone that interacts with membrane melatonin receptors MT1 and MT2, two different types of G-protein-coupled receptors expressed both in brain regions and peripheral tissues ( Pandi-Perumal et al, 2008 ; Pohanka, 2022 ). Melatonin regulates the circadian rhythm and affects sleep architecture.…”

Section: Introductionmentioning

confidence: 99%

Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice

et al. 2023

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Stress may trigger sleep disorders and are also risk factors for depression. The study explored the melatonin-related mechanisms of stress-associated sleep disorders on a mouse model of chronic stress by exploring the alteration in sleep architecture, melatonin, and related small molecule levels, transcription and expression of melatonin-related genes as well as proteins. Mice undergoing chronic restraint stress modeling for 28 days showed body weight loss and reduced locomotor activity. Sleep fragmentation, circadian rhythm disorders, and insomnia exhibited in CRS-treated mice formed sleep disorders. Tryptophan and 5-hydroxytryptamine levels were increased in the hypothalamus, while melatonin level was decreased. The transcription and expression of melatonin receptors were reduced, and circadian rhythm related genes were altered. Expression of downstream effectors to melatonin receptors was also affected. These results identified sleep disorders in a mice model of chronic stress. The alteration of melatonin-related pathways was shown to trigger sleep disorders.

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Section: Introductionmentioning

confidence: 99%

Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice

et al. 2023

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“…Administration of exogenous melatonin has proven useful in the management of specific sleep and circadian disorders. The effects of exogenous melatonin on sleep and circadian rhythm are mainly mediated by melatonin receptor 1 (MT1) and 2 (MT2) [12][13][14]. MT1 is closely related to phase shifting of circadian rhythms and REM sleep regulation, and MT2 can be associated with NREM sleep regulation [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…The effects of exogenous melatonin on sleep and circadian rhythm are mainly mediated by melatonin receptor 1 (MT1) and 2 (MT2) [12][13][14]. MT1 is closely related to phase shifting of circadian rhythms and REM sleep regulation, and MT2 can be associated with NREM sleep regulation [12][13][14]. Whether the findings are relevant for treatment of all patients with psychiatric disorders remains open.…”

Section: Introductionmentioning

confidence: 99%

Role of Melatonin in the Management of Sleep and Circadian Disorders in the Context of Psychiatric Illness

Moon

Kim

Partonen

et al. 2022

Curr Psychiatry Rep

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Purpose of Review We present a review of research on the role of melatonin in the management of sleep and circadian disorders, stressing current overall view of the knowledge across psychiatric disorders. Recent Findings Dysregulation of sleep and circadian rhythms has been established in several psychiatric and neurocognitive disorders for long. Recent research confirms this finding consistently across disorders. The secretion of melatonin in schizophrenia and neurocognitive disorders is reduced due to a smaller volume and enlarged calcification of the pineal gland. On the other hand, melatonin dysregulation in bipolar disorder may be more dynamic and caused by light-sensitive melatonin suppression and delayed melatonin secretion. In both cases, exogenous melatonin seems indicated to correct the dysfunction. However, a very limited number of well-designed trials with melatonin to correct sleep and circadian rhythms exist in psychiatric disorders, and the evidence for efficacy is robust only in autism, attention deficit hyperactivity disorder (ADHD), and neurocognitive disorders. This topic has mainly not been of interest for recent work and well-designed trials with objective circadian parameters are few. Overall, recent studies in psychiatric disorders reported that melatonin can be effective in improving sleep parameters such as sleep onset latency, sleep efficiency, and sleep quality. Recent meta-analysis suggests that optimal dosage and dosing time might be important to maximize the efficacy of melatonin. The knowledge base is sufficient to propose well-designed, larger trials with circadian parameters as inclusion and outcome criteria. Based on the partly fragmentary information, we propose testing efficacy in disorders with neurocognitive etiopathology with later and higher dosing, and affective and anxiety disorders with lower and earlier dosing of melatonin. Summary Melatonin is promising for the correction of sleep and circadian abnormalities in psychiatric disorders. However, research results on its effect are still few and need to be accumulated. For effective use of melatonin, it is necessary to consider the appropriate dosage and administration time, depending on the individual abnormality of sleep and circadian rhythms.

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“…In addition, we also quantified many health-related metabolites, such as melatonin (mr2076, Additional file 1 : Table S2). It is proven to be effective for insomnia, mood swing, drug abuse, and even cancer treatment [ 80 , 81 ]. We can unearth certain reliable loci controlling melatonin in B. napus [ 82 ].…”

Section: Discussionmentioning

confidence: 99%

Characterization of novel loci controlling seed oil content in Brassica napus by marker metabolite-based multi-omics analysis

Tian

Chen

et al. 2023

Genome Biol

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Background Seed oil content is an important agronomic trait of Brassica napus (B. napus), and metabolites are considered as the bridge between genotype and phenotype for physical traits. Results Using a widely targeted metabolomics analysis in a natural population of 388 B. napus inbred lines, we quantify 2172 metabolites in mature seeds by liquid chromatography mass spectrometry, in which 131 marker metabolites are identified to be correlated with seed oil content. These metabolites are then selected for further metabolite genome-wide association study and metabolite transcriptome-wide association study. Combined with weighted correlation network analysis, we construct a triple relationship network, which includes 21,000 edges and 4384 nodes among metabolites, metabolite quantitative trait loci, genes, and co-expression modules. We validate the function of BnaA03.TT4, BnaC02.TT4, and BnaC05.UK, three candidate genes predicted by multi-omics analysis, which show significant impacts on seed oil content through regulating flavonoid metabolism in B. napus. Conclusions This study demonstrates the advantage of utilizing marker metabolites integrated with multi-omics analysis to dissect the genetic basis of agronomic traits in crops.

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New Uses of Melatonin as a Drug; A Review

Cited by 16 publications

References 163 publications

Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice

Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice

Role of Melatonin in the Management of Sleep and Circadian Disorders in the Context of Psychiatric Illness

Characterization of novel loci controlling seed oil content in Brassica napus by marker metabolite-based multi-omics analysis

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