New variant Creutzfeldt-Jakob disease: psychiatric features

Zeidler, Martin; Johnstone, E. C.; Bamber, RW K; Dickens, Chris; Cj, Fisher; Francis, AF; Goldbeck, Rainer; Higgo, Robert; Johnson-Sabine, EC; Lodge, GJ; McGarry, Philip; Mitchell, Sara; Tarlo, L; Turner, Marc; Ryley, P; Rg, Will

doi:10.1016/s0140-6736(97)03148-6

Cited by 176 publications

(76 citation statements)

References 11 publications

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“…Patients with new variant CJD are younger at age of onset than CJD, and have prominent psychiatric features early in the illness. [7][8][9] These findings add further evidence to implicate a possible role of the prion gene in the pathogenesis of human mental disorders. In addition, Samaia et al 10 reported a novel missense mutation with asparagineto-serine alteration at codon 171 (N171S) of the prion gene in a three-generation family with psychiatric symptoms.…”

Section: Introductionsupporting

confidence: 54%

Lack of evidence to support the association of the human prion gene with schizophrenia

Chen

et al. 2000

Mol Psychiatry

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Recently a new variant of Creutzfeldt-Jakob disease, a human prion disease, with prominent psychiatric manifestations in the early stage was identified, suggesting that human prion disease may be associated with mental disorders. Furthermore, a novel missense mutation with asparagine-to-serine substitution at codon 171 of the human prion gene (N171S) was identified in a family with severe psychiatric symptoms. This finding provides further clue that the prion gene may be a susceptibility gene for certain psychiatric disorders. We systematically sequenced the protein-coding and untranslated exons of prion gene in 62 Han Chinese schizophrenic patients with positive family history from Taiwan. We identified two polymorphisms that alter amino acid sequences, a methionine/valine at codon 129 (M129V) and a glutamate/lysine at codon 219 (E219K), respectively. Further comparison of the genotype, allele and haplotype frequency distributions of these two polymorphisms between 234 schizophrenic patients and 100 non-psychotic controls, however, did not reveal significant differences between two groups. Besides, no other mutations in the prion gene were identified in these 62 patients. Hence, our results suggest that the prion gene may not play a major role in conferring susceptibility to schizophrenia. Molecular Psychiatry (2001) 6, 74-78.

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Section: Introductionsupporting

confidence: 54%

Lack of evidence to support the association of the human prion gene with schizophrenia

Chen

et al. 2000

Mol Psychiatry

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“…The clinical features are remarkably stereotyped. There is an initial phase of around 6 mo dominated by psychiatric symptoms, including depression, delusions, and anxiety 89 followed by the rapid development of neurological features, 90 typically confusion, ataxia, and involuntary movements, which may be choreiform, dystonic, or myoclonic. The duration of illness from onset to death averages 14 mo 91 in contrast to sCJD in which the mean survival is 4 mo.…”

Section: Diagnostics and Treatmentmentioning

confidence: 99%

Variant CJD

Diack

Head

McCutcheon

et al. 2014

Prion

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“…By March 2008, 163 cases of variant CJD had been identified in the UK by the national CJD surveillance unit (Zeidler 1997 …”

Section: Variant Creutzfeldt-jakob Disease (Bovine Spongiform Encephamentioning

confidence: 99%

Rare and unusual dementias

Gupta¹,

Fiertag²,

Warner³

2009

Adv. psychiatr. treat

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SummaryOver 95% of cases of dementia are attributable to Alzheimer's disease, vascular, Lewy body and frontotemporal dementia, and a few other common causes. In this article we consider some of the rare and unusual causes that account for the remaining 5%. Categorising them according to aetiological group (degenerative, vascular and infectious causes, and human prion diseases), we discuss the presentation of these forms and reasons for variations in estimated prevalence rates in the general population.

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New variant Creutzfeldt-Jakob disease: psychiatric features

Cited by 176 publications

References 11 publications

Lack of evidence to support the association of the human prion gene with schizophrenia

Lack of evidence to support the association of the human prion gene with schizophrenia

Variant CJD

Rare and unusual dementias

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