New Variotin Analogues from Aspergillus viridi-nutans

Omolo, Josiah Ouma; Anke, Heidrun; Chhabra, S. C.; Sterner, Olov

doi:10.1021/np990509b

Cited by 18 publications

(7 citation statements)

References 11 publications

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“…Thus, 1 H and 13 C NMR data suggested that 13 is a cyclohexenone derivative. [19][20][21][22] HMBC correlations were observed from H3-13 (δH 1.81) to C-2 (δC 115.5), C-1 (δC 202.2), and C-3 (δ C 177.8), from H 3 -14 (δ H 1.32) to C-1 (δ C 202.2) and C-6 (δ C 83.0), from H 3 -12 (δ H 4.08) to C-3 (δ C 177.8) and from H3-15 (δH 3.82) to C-5 (δC 172.3), confirming the presence of a cyclohexenone ring in 13 (Fig. 3).…”

Section: Resultsmentioning

confidence: 99%

α-Pyrones and Yellow Pigments from the Sponge-Derived Fungus Paecilomyces lilacinus

Elbandy¹,

Shinde²,

Hong³

et al. 2009

Bulletin of the Korean Chemical Society

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New α-pyrones (1 and 2) and cyclohexenones (13 and 14) were isolated along with known analogues (3, 5−12) from the ethyl acetate extract of the whole broth of the fungus Paecilomyces lilacinus, a strain derived from a marine sponge Petrosia sp. Their structures were established by interpretation of 1D and 2D NMR, and FABMS data. It is interesting to isolate cyclohexenone derivatives from the genus Paecilomyces (family Trichocomaceae, order Eurotiales), since these cyclohexenones were previously reported only from far distinct genera, Phoma and Alternaria (family Pleosporaceae, order Pleosporales). Compounds 6, 7, and 9 were evaluated for cytotoxicity against a small panel of human solid tumor cell lines. Their cytotoxicity was insignificant upto a concentration of 30 µg/mL.

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Section: Resultsmentioning

confidence: 99%

α-Pyrones and Yellow Pigments from the Sponge-Derived Fungus Paecilomyces lilacinus

Elbandy¹,

Shinde²,

Hong³

et al. 2009

Bulletin of the Korean Chemical Society

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“…Apart from being reported as being a potential mycotoxin, viriditoxin has also been reported to be a candidate for treatment of antibiotic resistant bacteria (Wang et al 2003). Among the known extrolites are the antifungal drug variotin (Takeuchi et al 1959, 1964, Suzuki et al 1990, Omolo et al 2000), and other drug candidates such as cornexistins (Nakajima et al 1991, Fields et al 1996), SCH 643432 (Hegde et al 2003) and a penicillin-like compound (Burton 1949). The sideramins ferrirubrin and fusigen (Diekmann 1967, Domsch et al 1980) and the organic acids 3-indole-acetic acid (Bakalinerov 1968, Voinova-Raikova et al 1969), citric acid (Loesecke 1945), ethyleneoxide-α, β-dicarboxylic acid (Sakaguchi et al 1939), (3Z,5E)-octa-3,5-diene -1,3,4-tricarboxylic acid 3,4-anhydride (Aldridge et al 1980) have also been reported.…”

Section: Discussionmentioning

confidence: 99%

Polyphasic taxonomy of the heat resistant ascomycete genus Byssochlamys and its Paecilomyces anamorphs

Samson¹,

Houbraken²,

Varga³

et al. 2009

Pers - Int Mycol J

135

123

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Byssochlamys and related Paecilomyces strains are often heat resistant and may produce mycotoxins in contaminated pasteurised foodstuffs. A comparative study of all Byssochlamys species was carried out using a polyphasic approach to find characters that differentiate species and to establish accurate data on potential mycotoxin production by each species. Phylogenetic analysis of the ITS region, parts of the β-tubulin and calmodulin genes, macro- and micromorphological examinations and analysis of extrolite profiles were applied. Phylogenetic analyses revealed that the genus Byssochlamys includes nine species, five of which form a teleomorph, i.e. B. fulva, B. lagunculariae, B. nivea, B. spectabilis and B. zollerniae, while four are asexual, namely P. brunneolus, P. divaricatus, P. formosus and P. saturatus. Among these, B. nivea produces the mycotoxins patulin and byssochlamic acid and the immunosuppressant mycophenolic acid. Byssochlamys lagunculariae produces byssochlamic acid and mycophenolic acid and thus chemically resembles B. nivea. Some strains of P. saturatus produce patulin and brefeldin A, while B. spectabilis (anamorph P. variotii s.s.) produces viriditoxin. Some micro- and macromorphological characters are valuable for identification purposes, including the shape and size of conidia and ascospores, presence and ornamentation of chlamydospores, growth rates on MEA and CYA and acid production on CREA. A dichotomous key is provided for species identification based on phenotypical characters.

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“…The Trichoderma species were cultured in various media as reported by Schneider [14] and Omolo [15]. The fungal test organisms were grown in yeast glucose malt (modified) agar medium while the bacterial test organisms were cultured in nutrient broth (Difco, USA) [14].…”

Section: Methodsmentioning

confidence: 99%

Bioactive metabolites from Trichoderma harzianum and Trichoderma longibrachiatum

Tarus

Langat‐Thoruwa

Wanyonyi

et al. 2004

Bull. Chem. Soc. Eth.

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The tea plant, Camellia sinensis (L.) O. Kuntze is an important crop in the agriculturally based economy of Kenya. Many diseases affect the tea plant but the most prevalent is armillaria root rot caused by the fungus Armillaria mellea. Compounds from the fermentation of Trichoderma species in different media were bioassayed against some selected gram-positive and gram-negative bacteria, fungi including Armillaria mellea, a yeast and a Mucor. Compounds obtained from T. harzianum, and T. longibrachiatum when cultured in various media were investigated individually for in-vitro antifungal and antibacterial activities by agar diffusion technique. Some of the compounds produced definite antifungal and antibacterial activities. 2-Phenylethanol (1) and tyrosol (2) obtained from T. harzianum are reported for the first time from Trichoderma species. The most active metabolite isolated from these strains was 6-n-pentyl-•pyrone (3), which showed the highest antifungal and antibacterial activity and completely inhibited the growth of Armillaria mellea fungus at a concentration of 200 ppm. Compound 4 (sorbicillin) exhibited moderate activity against the fungal test organisms.

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New Variotin Analogues from Aspergillus viridi-nutans

Cited by 18 publications

References 11 publications

α-Pyrones and Yellow Pigments from the Sponge-Derived Fungus Paecilomyces lilacinus

α-Pyrones and Yellow Pigments from the Sponge-Derived Fungus Paecilomyces lilacinus

Polyphasic taxonomy of the heat resistant ascomycete genus <I>Byssochlamys</I> and its <I>Paecilomyces</I> anamorphs

<b>Bioactive metabolites from <i>Trichoderma harzianum</i> and <i>Trichoderma longibrachiatum</i></b>

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