New vinegar produced by tomato suppresses adipocyte differentiation and fat accumulation in 3T3-L1 cells and obese rat model

Lee, Ju-Hye; Cho, Hyun‐Dong; Jeong, Ji-Hoon; Lee, Mi-Kyung; Jeong, Yong-Ki; Shim, Ki-Hwan; Seo, Kwon‐Il

doi:10.1016/j.foodchem.2013.05.126

Cited by 61 publications

(39 citation statements)

References 55 publications

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“…Visceral fat and lipid accumulation in adipocyte and obese rats were suppressed by TV, thus preventing obesity. Therefore, our animal experiments supported by the conclusions [64,65] establish that BBRDM-produced tomatoes are absolutely safe for consumption, considering the rat model as a surrogate for the human physiological system. To the best of our knowledge, this study represents the first animal-model food safety evaluation of tomatoes cultivated with an experimental organic fertilizer.…”

Section: Maximumsupporting

confidence: 63%

“…In all cases, wheat produced with organic fertilizer and organic crop protection was preferred to the wheat produced conventionally using inorganic fertilizers. Another study [65], reported surplus of tomatoes were abandoned due to their failure to satisfy customer standards. To allow value additions as well as to ensure effective re-use of surplus tomatoes, tomato vinegar (TV) containing phytochemicals was developed [65] and its anti-obesity effects in vitro and in vivo was evaluated using Sprague-Dawley rats.…”

Section: Maximummentioning

confidence: 99%

“…Another study [65], reported surplus of tomatoes were abandoned due to their failure to satisfy customer standards. To allow value additions as well as to ensure effective re-use of surplus tomatoes, tomato vinegar (TV) containing phytochemicals was developed [65] and its anti-obesity effects in vitro and in vivo was evaluated using Sprague-Dawley rats. Visceral fat and lipid accumulation in adipocyte and obese rats were suppressed by TV, thus preventing obesity.…”

Section: Maximummentioning

confidence: 99%

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Organic Cultivation of Tomato in India with Recycled Slaughterhouse Wastes: Evaluation of Fertilizer and Fruit Safety

et al. 2015

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Environmental and health safety of recycled slaughterhouse wastes-derived fertilizer and the produce obtained through its application is not well understood. Waste bovine blood and rumen digesta were mixed, cooked and sun-dried to obtain bovine-blood-and-rumen-digesta-mixture (BBRDM, NPK 30.36:1:5.75). 1.26 ± 0.18 log CFU mL −1 fecal coliforms were recovered in BBRDM. E. coli O157:H7, Mycobacteria, Clostridium sp., Salmonella sp., Bacillus sp. and Brucella sp. were absent. No re-growth of pathogens was observed after 60 days storage in sealed bags and in the open. However, prions and viruses were not evaluated. Heavy metals (Pb, Cr, Cd, Cu, Zn, As, Ni, Mn) concentrations in BBRDM were within internationally permissible limits. BBRDM was applied for field cultivation of tomato during 2012-2013 and 2013-2014. Lycopene and nitrate contents of BBRDM-grown tomatoes were higher than Diammonium OPEN ACCESSAgriculture 2015, 5 827 phosphate (DAP) + potash-grown tomatoes because BBRDM supplied 2.5 times more the amount of nitrogen than DAP (NPK 18:46:0) + potash (NPK 0:0:44). Heavy metals and nitrate/nitrite concentrations in tomatoes were within internationally acceptable limits. BBRDM-grown tomatoes showed no mutagenic activity in the Ames test. Sub-acute toxicity tests on Wistar rats fed with BBRDM-grown tomatoes did not show adverse clinical picture. Thus, no immediate environmental or health risks associated with BBRDM and the tomatoes produced were identified.

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Section: Maximumsupporting

confidence: 63%

Section: Maximummentioning

confidence: 99%

Section: Maximummentioning

confidence: 99%

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Organic Cultivation of Tomato in India with Recycled Slaughterhouse Wastes: Evaluation of Fertilizer and Fruit Safety

et al. 2015

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“…been reported have effects that include managing constipation [16], diabetes [17,18], obesity [14,19,20,21,22], inflammation [22], hypertension [23], immunity [24], lipid metabolism [19,20], and fatigue [25]. Additionally, many studies have reported that acetic acid, the key component of vinegar and contained, exhibits anti-obesity properties and improves lipid metabolism in animal models [17,19,26,27].…”

mentioning

confidence: 99%

Comparison of Anti-obesity Effects of Spirit Vinegar and Natural Fermented Vinegar Products on the Differentiation of 3T3-L1 Cells and Obese Rats Fed a High-fat Diet

Son¹,

Kim²,

Shin³

et al. 2017

JFNR

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This study aimed to compare the effects of spirit vinegar and four types of natural fermented vinegar products (apple vinegar, brown rice vinegar, lemon vinegar, and balsamic vinegar) on the differentiation of 3T3-L1 cells and obesity in rats fed a high-fat diet (HFD). Vinegar inhibited the accumulation of lipid droplets during the differentiation of 3T3-L1 cells. Body weight gains, visceral fat pad weights, serum leptin and triglyceride levels, and hepatic lipogenic enzyme mRNA levels were significantly decreased in the HF-vinegar administered groups compared with those in the HF group. Furthermore, oral administration of vinegars significantly reduced the occurrence of fatty liver deposits and steatosis, and inhibited the HF diet-induced increase in adipocyte size. The anti-obesity and lipid-lowering effects were slightly greater in the HF-natural fermented vinegar groups than in the HF-spirit vinegar group. Apple vinegar had the strongest anti-obesity effects in 3T3-L1 cells and obese rats compared with the other tested vinegars. These findings indicated that vinegar administration may have potential for improving some obesity-related parameters in 3T3-L1 cells and obese rats.

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“…In a study by Lee et al (2013), tomato vinegar was produced and evaluated as to the efficacy of the treatment of lipid accumulation in 3T3-L1 adipocytes and in rats fed a high-fat diet. The rats were fed with a dose of 7 ml/kg/day, for 5 weeks, corresponding to the amount of drink per day in humans.…”

Section: Other Benefitsmentioning

confidence: 99%

Vinegar: functional aspects

Pazuch¹,

Siepmann²,

Canan³

et al. 2015

Científica

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New vinegar produced by tomato suppresses adipocyte differentiation and fat accumulation in 3T3-L1 cells and obese rat model

Cited by 61 publications

References 55 publications

Organic Cultivation of Tomato in India with Recycled Slaughterhouse Wastes: Evaluation of Fertilizer and Fruit Safety

Organic Cultivation of Tomato in India with Recycled Slaughterhouse Wastes: Evaluation of Fertilizer and Fruit Safety

Comparison of Anti-obesity Effects of Spirit Vinegar and Natural Fermented Vinegar Products on the Differentiation of 3T3-L1 Cells and Obese Rats Fed a High-fat Diet

Vinegar: functional aspects

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