New β-carboline and indole alkaloids from Actinomycete Actinomadura sp. BCC 24717

Kornsakulkarn, Jittra; Saepua, Siriporn; Boonruangprapa, Tanapong; Suphothina, Sumalee; Thongpanchang, Chawanee

doi:10.1016/j.phytol.2013.06.007

Cited by 15 publications

(14 citation statements)

References 19 publications

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“…Examination of actinomycete Actinomadura BCC 24717 led to the isolation of 1-hydroxymethylindole-3-carboxylic acid ( 142 ) and 1-methyl indole-3-carboxamide ( 143 ) with the latter compound displaying antifungal activity against Candida albican s (IC 50 41.97 μg/mL) ( Figure 36 ) [ 91 ].…”

Section: Marine Indole Alkaloidsmentioning

confidence: 99%

Marine Indole Alkaloids

2015

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Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in addition to the action on human enzymes and receptors. The newly isolated indole alkaloids of marine origin since the last comprehensive review in 2003 are reported, and biological aspects will be discussed.

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Section: Marine Indole Alkaloidsmentioning

confidence: 99%

Marine Indole Alkaloids

2015

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“…In contrast, JBIR-133 ( 2 ) and kitasetaline ( 3 ) neither revealed biological activity, as well the compound methyl 1-(propionic acid)- β-carboline -3-carboxylic acid ( 4 ) [17], indicating that the vinyl side chain attached at 1-position in compound 1 is crucial for the biological activities of this natural product. β -Carbolines are nitrogen-containing heterocyclic compounds that consists of a pyridine ring fused to an indole skeleton [6].…”

Section: Discussionmentioning

confidence: 99%

Microbispora sp. LGMB259 Endophytic Actinomycete Isolated from Vochysia divergens (Pantanal, Brazil) Producing β-Carbolines and Indoles with Biological Activity

et al. 2014

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Endophytic actinomycetes encompass bacterial groups that are well known for the production of a diverse range of secondary metabolites. Vochysia divergens is a medicinal plant, common in the “Pantanal” region (Brazil) and was focus of many investigations, but never regarding its community of endophytic symbionts. During a screening program, an endophytic strain isolated from the V. divergens, was investigated for its potential to show biological activity. The strain was characterized as Microbispora sp. LGMB259 by spore morphology and molecular analyze using nucleotide sequence of the 16S rRNA gene. Strain LGMB259 was cultivated in R5A medium producing metabolites with significant antibacterial activity. The strain produced 4 chemically related β-carbolines, and 3 Indoles. Compound 1-Vinyl-β-carboline-3-carboxylic acid displayed potent activity against the Gram-positive bacterial strains Micrococcus luteus NRRL B-2618 and Kocuria rosea B-1106, and was highly active against two human cancer cell lines, namely the prostate cancer cell line PC3 and the non-small-cell lung carcinoma cell line A549, with IC50 values of 9.45 and 24.67 µM, respectively. 1-Vinyl-β-carboline-3-carboxylic acid also showed moderate activity against the yeast Saccharomyces cerevisiae ATCC204508, as well as the phytopathogenic fungiPhyllosticta citricarpa LGMB06 and Colletotrichum gloeosporioides FDC83.

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“…BCC 24717, exhibited cytotoxicity to Vero African green monkey kidney cell lines, whereas 1-vinylβ-carboline-3-carboxylic acid showed moderate activity against KB cells, human small cell lung cancer (NCI-H187), and Vero cells. 68 3.12 | FTIR analysis of VITGAP173 EA extract FTIR spectral analysis data of VITGAP173 EA extract revealed the presence of multiple functional groups in them ( Figure 9B). Spectral data of the extract confirmed the presence of amines (C = N), aliphatic (C-N) and aromatic amines (N-H), nitro compounds (NO), esters (C-O), alkyl (C-H), and carboxylic acids (C = O) are shown in Table 6.…”

Section: Gc-ms Analysis Of Vitgap173 Ea Extractmentioning

confidence: 99%

Investigation of anti‐inflammatory and toxicity effects of mangrove‐derived Streptomyces rochei strain VITGAP173

Gomathi

Gothandam

2019

J of Cellular Biochemistry

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Mangrove ecosystems generate the major biodiversity hotspots of actinobacteria. Among the actinobacteria, Streptomyces species are the prolific producers of bioactive natural products. In this study, with research efforts to discover biopotential compounds from marine actinobacteria, 41 actinobacterial strains were isolated from sediment soil sample of Indian mangrove regions. The phylogeny prediction using the 16S rRNA gene sequences revealed that the isolates were related to Streptomyces. Isolates were further screened based on a two‐step process wherein the first step, around nine strains, unveiled the presence of type 1 polyketide synthase gene and dTDP‐glucose 4,6‐dehydratase gene through polymerase chain reaction. As the second step of the screening process, cell viability assay was performed in RAW264.7 cells to assess the toxicity of extracts. Among all the isolates, Streptomyces rochei strain VITGAP173 was subjected to further analysis. To explore the bioactivities, the organic solvent extraction method was utilized to extract the broth culture of VITGAP173. Inhibition of nitric oxide and cyclooxygenase enzymes upon lipopolysaccharide‐induced inflammation were utilized to evaluate the anti‐inflammatory efficacy, and the results showed the potency of VITGAP173 in a dose‐dependent manner. The extract significantly suppressed the messenger RNA levels of the inflammatory mediators such as tumor necrosis factor‐α and interleukin‐6 induced by lipopolysaccharide in RAW264.7 macrophages. The presence of several chemical constituents was identified through gas chromatography‐mass spectrometry analysis of VITGAP173 extract. To achieve the toxicity analysis, oral administration of VITGAP173 extract in Wistar albino rats was carried out to investigate the biochemical parameters, histopathology which revealed its nontoxic nature.

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New β-carboline and indole alkaloids from Actinomycete Actinomadura sp. BCC 24717

Cited by 15 publications

References 19 publications

Marine Indole Alkaloids

Marine Indole Alkaloids

Microbispora sp. LGMB259 Endophytic Actinomycete Isolated from Vochysia divergens (Pantanal, Brazil) Producing β-Carbolines and Indoles with Biological Activity

Investigation of anti‐inflammatory and toxicity effects of mangrove‐derived Streptomyces rochei strain VITGAP173

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