Newborn feeding behaviour depressed by intrapartum oxytocin: a pilot study

Fernández, Ibone Olza; Gabriel, Miguel Marín; Martínez, Ana Malalana; Morillo, Aurora Fernández‐Cañadas; Sánchez, Francisco López; Costarelli, Valeria

doi:10.1111/j.1651-2227.2012.02668.x

Cited by 69 publications

(54 citation statements)

References 29 publications

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“…Little is known about other possible long-term effects of oxytocin administration during labor on the physiology of the mother. A recent study (42), however, has linked intrapartum exogenous oxytocin to difficulties with sucking behavior in the newborn and a decreased duration of breastfeeding. Given the role of oxytocin in lactation, the long-term effect of exogenous oxytocin on endogenous oxytocin may be relevant to explaining this finding.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin in Pregnancy and the Postpartum: Relations to Labor and Its Management

Prévost

Zelkowitz

Tulandi

et al. 2014

Front. Public Health

145

131

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The purpose of this study was to examine variations in endogenous oxytocin levels in pregnancy and postpartum state. We also explored the associations between delivery variables and oxytocin levels. A final sample of 272 mothers in their first trimester of pregnancy was included for the study. Blood samples were drawn during the first trimester and third trimester of pregnancy and at 8 weeks postpartum. Socio-demographic data were collected at each time point and medical files were consulted for delivery details. In most women, levels of circulating oxytocin increased from the first to third trimester of pregnancy followed by a decrease in the postpartum period. Oxytocin levels varied considerably between individuals, ranging from 50 pg/mL to over 2000 pg/mL. Parity was the main predictor of oxytocin levels in the third trimester of pregnancy and of oxytocin level changes from the first to the third trimester of pregnancy. Oxytocin levels in the third trimester of pregnancy predicted a self-reported negative labor experience and increased the chances of having an epidural. Intrapartum exogenous oxytocin was positively associated with levels of oxytocin during the postpartum period. Our exploratory results suggest that circulating oxytocin levels during the third trimester of pregnancy may predict the type of labor a woman will experience. More importantly, the quantity of intrapartum exogenous oxytocin administered during labor predicted plasma oxytocin levels 2 months postpartum, suggesting a possible long-term effect of this routine intervention, the consequences of which are largely unknown.

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Section: Discussionmentioning

confidence: 99%

Oxytocin in Pregnancy and the Postpartum: Relations to Labor and Its Management

Prévost

Zelkowitz

Tulandi

et al. 2014

Front. Public Health

145

131

View full text Add to dashboard Cite

show abstract

“…For example, higher synOT dosage was associated with less successful breastfeeding, as well as with the detection of ASD at six years of age ( n = 400) [74]. Similarly, higher synOT dosage has been associated with less likelihood of exclusive breastfeeding at three months, as well as less optimal sucking behaviors ( n = 20) [75]. Prefeeding behavioral cues one hour after birth have been examined in relation to synOT exposure ( n = 47).…”

Section: Evaluation Of the Hypothesismentioning

confidence: 99%

The EPIIC hypothesis: Intrapartum effects on the neonatal epigenome and consequent health outcomes

et al. 2013

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There are many published studies about the epigenetic effects of the prenatal and infant periods on health outcomes. However, there is very little knowledge regarding the effects of the intrapartum period (labor and birth) on health and epigenetic remodeling. Although the intrapartum period is relatively short compared to the complete perinatal period, there is emerging evidence that this time frame may be a critical formative phase for the human genome. Given the debates from the National Institutes of Health and World Health Organization regarding routine childbirth procedures, it is essential to establish the state of the science concerning normal intrapartum epigenetic physiology. EPIIC (Epigenetic Impact of Childbirth) is an international, interdisciplinary research collaboration with expertise in the fields of genetics, physiology, developmental biology, epidemiology, medicine, midwifery, and nursing. We hypothesize that events during the intrapartum period – specifically the use of synthetic oxytocin, antibiotics, and cesarean section – affect the epigenetic remodeling processes and subsequent health of the mother and offspring. The rationale for this hypothesis is based on recent evidence and current best practice.

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“…There is paucity of data on the effects of SynOT in newborn offspring. Some studies have found an association between SynOT peripartum exposure and increased incidence of unwanted breastfeeding cessation as well as changes in newborn offspring feeding behaviour including lower prefeeding cues, suction and swallowing. However, results in this area of research are mixed.…”

Section: Discussionmentioning

confidence: 99%

Parental adiposity differentially associates with newborn body composition

et al. 2019

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Summary Background Maternal obesity increases offspring's obesity risk. However, studies have not often considered maternal metabolic and exercise patterns as well as paternal adiposity as potential covariates. Objective To assess the relationship between parental and newborn adiposity. Methods Participants were mother‐child pairs (n = 209) and mother‐father‐offspring triads (n = 136). Parental (during gestation) and offspring (2 weeks old) percent fat mass (FM) were obtained using air displacement plethysmography. Maternal race, age, resting energy expenditure (indirect calorimetry), physical activity (accelerometry), gestational weight gain (GWG), gestational age (GA), delivery mode, infant's sex and infant feeding method were incorporated in multiple linear regression analyses. The association between parental FM and offspring insulin‐like growth factor 1 (IGF‐1) was assessed at age 2 years. Results Maternal adiposity was positively‐associated with male (β = 0.11, P = .015) and female (β = 0.13, P = .008) infant FM, whereas paternal adiposity was negatively‐associated with male newborn adiposity (β = ‐0.09, P = .014). Breastfeeding, female sex, GA and GWG positively associated with newborn adiposity. Vaginal and C‐section delivery methods associated with greater adiposity than vaginal induced delivery method. Plasma IGF‐1 of 2‐year‐old boys and girls positively associated with their respective fathers' and mothers' FM. Conclusions Maternal and paternal adiposity differentially associate with newborn adiposity. The mechanisms of this finding remain to be determined.

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Newborn feeding behaviour depressed by intrapartum oxytocin: a pilot study

Abstract: In this pilot study, intrapartum exogenous oxytocin seems to disturb sucking and breastfeeding duration. Further studies are required to confirm these results and to ascertain whether there could be other effects of intrapartum oxytocin on newborn behaviour.

Cited by 69 publications

References 29 publications

Oxytocin in Pregnancy and the Postpartum: Relations to Labor and Its Management

Oxytocin in Pregnancy and the Postpartum: Relations to Labor and Its Management

The EPIIC hypothesis: Intrapartum effects on the neonatal epigenome and consequent health outcomes

Parental adiposity differentially associates with newborn body composition

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