Newborns and preterm infants at term equivalent age: A semi-quantitative assessment of cerebral maturity

Pittet, Marie P.; Vasung, Lana; Hüppi, Petra Susan; Merlini, Laura

doi:10.1016/j.nicl.2019.102014

Cited by 27 publications

(29 citation statements)

References 52 publications

(80 reference statements)

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“…We also found that the fetal transient compartments (Pittet et al, 2019) have high contrast in the T2w, T1w, FISO, MD, RD and TDI γ c maps.…”

Section: Running Titlesupporting

confidence: 56%

“…7.B). The parcellation map has 24 regions with the majority being consistent with the transient fetal compartment regions described in the recently introduced extended MRI scoring systems of cerebral maturation (Pittet et al, 2019) including periventricular crossroads, Von Monakow WM segments and subplate. We also identified fast developing regions within the cerebellum and subcortical grey matter.…”

Section: Frontiers 13supporting

confidence: 55%

“…The γ M D map of the MD channel (Fig.9.D) shows high decrease in the superior corona radiata, sagittal stratum and the transient fetal compartments associated with WM maturation (Pittet et al, 2019) including the periventricular crossroads and subplate regions (highlighted with arrows). The MD signal is slowly decreasing the PLIC region as can be seen in the corresponding graph (blue).…”

Section: Visual Analysis Of Normal Neonatal Brain Developmentmentioning

confidence: 99%

“…and fitted signal values Y ref c (t) of the TDI and T1w channels computed in the small Von Monakow WM segment(Pittet et al, 2019) highlighted in yellow in the T1w channel.…”

mentioning

confidence: 99%

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Multi-channel 4D parametrized Atlas of Macro- and Microstructural Neonatal Brain Development

Uus

Grigorescu

Pietsch

et al. 2021

Preprint

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Structural and diffusion MRI provide complimentary anatomical and microstructural characterization of early brain maturation. The existing models of the developing brain in time include only either structural or diffusion channels. Furthermore, there is a lack of tools for combined analysis of structural and diffusion MRI in the same reference space. In this work we propose methodology to generate multi-channel (MC) continuous spatio-temporal parametrized atlas of brain development based on MC registration driven by both T2-weighted and orientation distribution functions (ODF) channels along with the Gompertz model (GM) fitting of the signals and spatial transformations in time. We construct a 4D MC atlas of neonatal brain development during 38 to 44 week PMA range from 170 normal term subjects from developing Human Connectomme Project. The resulting atlas consists of fourteen spatio-temporal microstructural indices and two parcellation maps delineating white matter tracts and neonatal transient structures. We demonstrate applicability of the atlas for quantitative region-specific comparison of 140 term and 40 preterm subjects scanned at the term-equivalent age. We show multi-parametric microstructural differences in multiple white matter regions, including the transient compartments. The atlas and software will be available after publication of the article.

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“…We also found that the fetal transient compartments (Pittet et al, 2019) have high contrast in the T2w, T1w, FISO, MD, RD and TDI γ c maps.…”

Section: Running Titlesupporting

confidence: 56%

Section: Frontiers 13supporting

confidence: 55%

Section: Visual Analysis Of Normal Neonatal Brain Developmentmentioning

confidence: 99%

“…and fitted signal values Y ref c (t) of the TDI and T1w channels computed in the small Von Monakow WM segment(Pittet et al, 2019) highlighted in yellow in the T1w channel.…”

mentioning

confidence: 99%

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Multi-channel 4D parametrized Atlas of Macro- and Microstructural Neonatal Brain Development

Uus

Grigorescu

Pietsch

et al. 2021

Preprint

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“…Prematurity also may alter the maturation patter as measured in a study that compared premature and full-terms by equivalent age using 3T MRI T2-weighted and showed that the majority of transient fetal compartments were less mature in preterm group at term equivalent age, though von Monakow segments of the white matter and subplate compartment presented a more advanced maturational stage in the preterm group compared to the term group. 28 These differences are still to be investigated at long term. Because they are the first neural cells to mature, SPNs are the most vulnerable cells to hypoxia-ischemic processes common in prematures.…”

Section: Cognitive Impairmentmentioning

confidence: 98%

Untitled

2020

JNSK

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The search for articles was conducted in January 2020 in six databases: Academic Google, PubMed, SciElo, Cochrane Library, Scopus and Web of Science. The keywords used in all databases were: "subplate neurons", "newborn or neonate and subplate neuron", "neurodevelopment disorder and subplate neurons", "cognition and subplate neurons", "stress and subplate neurons", "pain or nociception and subplate neurons", "Autism and subplate neurons", "Schizophrenia and subplate neurons". Each combination corresponded to an individual query. Keywords had to appear in the title or abstract. No restrictions were placed on language or year of publication. The inclusion criteria for this review covered original articles and review articles explaining the formation, functions, and changes related to the SPN. Exclusion criteria were studies that did not address SPN and cognition, neurodevelopmental disorder, mental retardation, autism, pain, nociception, schizophrenia or stress. Thus, 566 of the 623 previously chosen articles were excluded (Figure 1) mainly for reasons as animal study, only physiologic analyses, not newborn infant or other reasons as oral/poster presentation only. Reporting of the results followed the Preferred Reporting Items of Systematic reviews and Meta-Analyses (PRISMA) statement of 2009.

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Evaluation of Glymphatic System Development in Neonatal Brain via Diffusion Analysis along the Perivascular Space Index

Lin,

Guo,

Liang

et al. 2024

Annals of Neurology

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ObjectiveGlymphatic system is a recently discovered macroscopic waste clearance system associated with numerous neurological diseases. However, little is known about glymphatic system development in neonates. We sought to evaluate diffusion along the perivascular space (ALPS) index, a proxy for glymphatic system function, in neonates and investigate its potential associations with maturation, sex, and preterm birth.MethodsDiffusion magnetic resonance imaging (MRI) data in 418 neonates, including 92 preterm neonates (57 males) and 326 term neonates (175 males), from the Developing Human Connectome Project were used for evaluating ALPS index. Linear regression modeling was performed to assess group differences in the ALPS index according to preterm birth and sex. Pearson's and partial correlation analysis were performed to assess the association between the ALPS index and gestational age (GA) as well as postmenstrual age (PMA) at MRI. Moderation analysis was performed to assess the moderation effect of preterm birth on the relationship between the ALPS index and PMA.ResultsCompared to term neonates, preterm neonates exhibited lower ALPS indices (p < 0.001). The ALPS index positively correlated with PMA (p = 0.004) and GA (p < 0.001). Preterm birth (p = 0.013) had a significant moderation effect on the relationship between the ALPS index and PMA. Sex had no significant direct effect (p = 0.639) or moderation effect (p = 0.333) on ALPS index.InterpretationGlymphatic system development is a dynamic process in neonates, which can be moderated by preterm birth, the ALPS index could serve as a sensitive biomarker for monitoring this process. ANN NEUROL 2024

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Newborns and preterm infants at term equivalent age: A semi-quantitative assessment of cerebral maturity

Cited by 27 publications

References 52 publications

Multi-channel 4D parametrized Atlas of Macro- and Microstructural Neonatal Brain Development

Multi-channel 4D parametrized Atlas of Macro- and Microstructural Neonatal Brain Development

Untitled

Evaluation of Glymphatic System Development in Neonatal Brain via Diffusion Analysis along the Perivascular Space Index

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