Newcastle disease virus: Macromolecules and opportunities

Abstract

Over the past two decades, enormous advances have occurred in the structural and biological characterization of Newcastle disease virus (NDV). As a result, not only the complete sequence of the viral genome has been fully determined, but also a clearer understanding of the viral proteins and their respective roles in the life cycle has been achieved. This article reviews the progress in the molecular biology of NDV with emphasis on the new technologies. It also identifies the fundamental problems that need to be addressed and attempts to predict some research opportunities in NDV that can be realized in the near future for the diagnosis, prevention and treatment of disease(s).

The Oncolytic Activity of Newcastle Disease Virus in Clear Cell Renal Carcinoma Cells in Normoxic and Hypoxic Conditions: The Interplay Between von Hippel-Lindau and Interferon-β Signaling

“…A Malaysian-isolated velogenic strain of NDV, designated as AF2240 (reviewed in Yusoff and Tan 2001), was obtained from the Veterinary Research Laboratory, Ipoh, Malaysia. Virus propagation and purification were performed as previously described (Yusoff and others 1996).…”

“…In NDV infection, induction of cytokines leads to enhanced NDV oncolytic activity (Zorn and others 1994). Recently, a local isolate of a viscerotropicvelogenic strain of NDV (reviewed in Yusoff and Tan 2001), designated AF2240, was shown to be oncolytic in several cancer cell lines (Alabsi and others 2011;Ali and others 2011). This highly oncolytic NDV strain may represent an unexplored avenue for developing a more potent cancer virotherapy agent.…”

Targeted Therapy for Gliomas: the Oncolytic Virus Applications

“…Electron microscopic study reveals that the protein exists as flexible helical structure with a diameter of about 18 nm in length and 1 µm height. Its structure resembles classical morphology with spikes protruding from the central channel (Yusoff and Tan, 2001). Each NP subunits consists of 489 amino acids with molecular mass of about 53 kDa.…”

Pathotypic characterization of the Newcastle disease virus isolated from commercial poultry in northwest Iran

“…Two additional proteins, V and W, are derived by inserting 1 or 2 guanines during the transcription of P gene mRNA (6). The two surface glycoproteins HN and F are responsible for binding to host cell sialic acid receptors and for the fusion of the viral envelope to the host cell membrane, respectively (3,7).…”