Newcastle diseases virus strain V4UPM displayed oncolytic ability against experimental human malignant glioma

Abstract

From this study, NDV strain V4UPM inhibits the proliferation of experimental human gliomas in tissue culture and IC(80) at 520 HAU V4UPM gives potent effect to induced tumor regression and apoptosis in malignant gliomas.

Oncolytic Newcastle Disease Virus for Cancer Therapy: Old Challenges and New Directions

“…Promising results were noted in preclinical models of leukemia, lymphoma, melanoma, neuroblastoma, fibrosarcoma, rat pheochromocytoma, colon carcinoma, lung carcinoma, prostate carcinoma, breast carcinoma, gastric carcinoma, mesothelioma, and head and neck carcinoma [7,9,12,13,26,27,31,34–36,56,59,68,70,77,92,107,108,122–128]. Clinical studies that followed consisted of NDV-based tumor vaccines and direct administration of naturally-occurring NDV to patients with advanced cancers and in post-operative setting.…”

CdTe quantum dots as fluorescent probes to study transferrin receptors in glioblastoma cells

“…A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 22 As mentioned before, the DBTRG-05MG cell line was originated from the tumor tissue of a patient owing a recurrent glioblastoma that has been treated with irradiation and chemotherapy [38]. This variant of glioblastoma is more aggressive and resistant to current chemotherapy when compared to that originated from U87 cells [39][40][41], which can also justify the high metabolic rate and the probably faster recycling of the TfR observed in DBTRG-05MG cells. reported previously in HeLa cells [16,19,35].…”

Targeted Therapy for Gliomas: the Oncolytic Virus Applications

“…It is been tested to poses excellent oncolytic activity against glioma cell lines. (Zulkifli et al, 2009) et al, 2010) . In the clinical practice, China is reported to be the first country that has approved the oncolytic virus application in 2006.…”

“…For the cytotoxicity study, adapted from the method by Zulkifli et al, 2009, the normal and glioma cell lines were seeded at 1 x 10 5 in 96-well plate and incubated overnight in 37°celcius incubator supplemented with 5% CO 2 gas. Following the attachment of the cells next day, the media was changed.…”