Newer Anaesthetic Agents in Children, With Special Reference to Trichlorethylene and Kemithal

Pharmacology and toxicology of trichloroethylene: A critical review of the world literature

“…Treatment of tachypnea is suggested by the previous observations: avoidance of trichloroethylene in young children, slow induction after intravenous thiobarbiturates, and use of the least concentration compatible with anesthesia. Other measures suggested involve high concentration of oxygen 101, 231, 311, 423 and administration of 25 to 50 mg. of meperidine Intravenously.v- 88,131,239,389,390,391 The mechanism of the effeet of meperidine is still unknown. It may be areduction in the concentration of trichloroethylene needed, or inhaled, a direet action upon the respiratory center.P" or suppression of bronchospasm caused by trichlorothylene.…”

“…' 5, 45, 129, 140, 179, 181, 218, 220, 223, 237, 305, 323, 353, 360, 389, 415 A few authors describe excitement.s"- 174, 195, 208, 398 cough and Iaryngospasm.v-288 or slow and diffi-cult induction. ": 131, 280, 308 These contradietions are probably due to differences in technique and skill, Although several workers claim to have reached plane 3 or 4 of the surgical stage and to have obtained good muscle relaxation,179, 206, 308 the majority believe that because of cardiorespiratory complications, it is difficult and unwise to go deeper than plane 1 and that good muscle relaxation is difficult to obtain.s"- 88,131,174,195,210,211,212,220,223,280,311,389,423 However, for unknown reasons, relaxation of the mandibular muscles is often sufficient to permit oral intubation. 63,129,192 Analgesia.…”

“…,61,88,98,101,116, 173,174,192,195,208,211,212,220,238,288,299,311, 368,389,398,423,437 as weIl as in dogs,291, 308, 427, 429 cats."" and rodents.…”