Newer approaches to the diagnosis of early onset neonatal sepsis

Mishra, Umesh; Jacobs, Susan E; Doyle, Lex W.; Garland, Suzanne M.

doi:10.1136/adc.2004.064188

Cited by 155 publications

(148 citation statements)

References 43 publications

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“…Malondyaldehide Assay MDA was measured by the method of Buege and Aust [28]. The colour was measured spectrophotometrically at 532 nm.…”

Section: A Hydrogen Peroxide Assaymentioning

confidence: 99%

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Oxidative Stress and Kidney Glycation in Rats Exposed Cadmium

Suhartono¹

2014

IJCEA

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Abstract-Cadmium (Cd) is a heavy metal and it was proposed in the formation of Reactive Oxygen Species (ROS) and Advance Glycation End Products (AGEs). The role of Cd induced oxidative stress and glycation in kidney has not been much studied. Thus our study aimed to measure the oxidative stress and glycation in kidney exposed to Cd. The present study was a true experimental study design to examine the impact of Cd exposure in renal rats (Rattus novergicus) male. The study involved 4 groups, K0 was the control group, while the other (K1,K2,K3) was the case group with exposure of Cd in different concentration. For analyzing of the data, SPSS software version 17 was used and was examined by ANOVA test. The resulted showed that there are a significance differences of MDA, H 2 O 2, SOD activity and AOPP between case and control group, but there are not MG and CC are not sgnificance differences. Our study showed Cd induced oxidative stress but not caused glycation reaction.Index Terms-AOPP, cadmium, glycation and oxidative stress.

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“…Malondyaldehide Assay MDA was measured by the method of Buege and Aust [28]. The colour was measured spectrophotometrically at 532 nm.…”

Section: A Hydrogen Peroxide Assaymentioning

confidence: 99%

“…The pellet is then dissolved in 600 μL of 6M guanidine hydrochloride. The carbonyl content is determined by reading the absorbance at the optimum wavelength 390 nm [28].…”

Section: F Carbonyl Compound Assaymentioning

confidence: 99%

Oxidative Stress and Kidney Glycation in Rats Exposed Cadmium

Suhartono¹

2014

IJCEA

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“…The pellet is then dissolved in 600 μL of 6M guanidine hydrochloride. The carbonyl content is determined by reading the absorbance at the optimum wavelength 390 nm [21].…”

Section: A Data Analysis 1) Carbonyl Compound Assaymentioning

confidence: 99%

The Role Formation of Methylglyoxal, Carbonyl Compound, Hydrogen Peroxide and Advance Oxidation Protein Product Induced Cadmium in Ovarian Rat

Husna¹,

Ramadhani²,

Eva³

et al. 2014

IJCEA

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“…To determine whether the patient has intraamniotic inflammation, and thus should be delivered rather than managed expectantly or even treated with tocolytic agents, is often a critical decision with clinical implications for both mother and fetus. 4 Unfortunately, currently there is a lack in noninvasive tests that would provide reliable early screening for fetal infection detection and thereby would help the obstetrician to recognize the need for antibiotic treatment, cessation of tocolysis, or early delivery. Antenatal detection of neonatal infection would also enable the physicians to more accurately select the population of newborn infants that require antibiotic treatment.…”

Section: Introductionmentioning

confidence: 99%

“…2,[5][6][7][8] Therefore, there is a need for the development of sensitive tests for the prediction of inborn infection that are of value in the management of the immediate neonatal period. 4,9 Maternal serum is an easily reachable biological material that is collected in almost noninvasive way. Some inflammatory mediators may also be detected in vaginal or cervical secretions, and it is probable that their concentrations in the vaginal compartment, especially after rupture of membranes, reflect their intraamniotic concentrations.…”

Section: Introductionmentioning

confidence: 99%

Maternal serum and vaginal fluid C-reactive protein levels do not predict early-onset neonatal infection in preterm premature rupture of membranes

Torbé

Kowalski

2010

J Perinatol

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Objective: The aim of this study was to evaluate the usefulness of maternal serum and vaginal fluid C-reactive protein (CRP) determinations in the prediction of neonatal congenital infection.Study Design: Fifty women between 24 and 36 weeks gestation, complicated by preterm premature rupture of membranes (pPROM), were divided into two groups according to the presence (n ¼ 14) or absence (n ¼ 36) of early-onset newborns' infection.Result: Maternal serum and vaginal fluid CRP concentrations were comparable between both groups. Serum CRP levels X10 and X15 mg l -1 predicted neonatal infection with a sensitivity of 47 and 47%, specificity of 63 and 76%, positive predictive value (PPV) of 38 and 47%, and negative predictive value (NPV) of 72 and 76%, respectively. The cutoff value of vaginal CRP X2.4 mg l -1 predicted infection with a sensitivity of 71%, specificity of 47%, PPV of 34%, and NPV of 81%. Receiver-operating characteristic curve analysis revealed that the predictive performance of CRP was poor.Conclusion: Maternal serum and vaginal fluid CRP determinations after pPROM are of poor predictive value in neonatal early-onset infection prediction.

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Newer approaches to the diagnosis of early onset neonatal sepsis

Cited by 155 publications

References 43 publications

Oxidative Stress and Kidney Glycation in Rats Exposed Cadmium

Oxidative Stress and Kidney Glycation in Rats Exposed Cadmium

The Role Formation of Methylglyoxal, Carbonyl Compound, Hydrogen Peroxide and Advance Oxidation Protein Product Induced Cadmium in Ovarian Rat

Maternal serum and vaginal fluid C-reactive protein levels do not predict early-onset neonatal infection in preterm premature rupture of membranes

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