Newer risk assessment strategies in hypertrophic cardiomyopathy

Chaudhry-Waterman, Nadia; Cohen, Mitchell I.

doi:10.1097/hco.0000000000000804

Cited by 3 publications

(3 citation statements)

References 63 publications

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“… 57 In addition, especially young family members should be considered for early screening, as the phenotype of HCM is varied and includes a higher risk of adverse outcomes when diagnosed during childhood. 4 , 55 , 58 This early screening is in line with the current 2020 AHA/ACC guidelines, which endorses to clinically (and genetically) screen younger at-risk family members at any age, instead of starting from the previously recommended age of ten years. 1 , 59 Also, implementation of repeated clinical assessment is required throughout child- and adulthood.…”

Section: Cmr For Family Screeningsupporting

confidence: 68%

“…At this moment, a lot of the diagnostic, prognostic and risk stratification models for children with HCM are largely extrapolated from adult HCM criteria, especially for the implementation of CMR findings. 1 , 58 To unravel the specific paediatric characteristics, to establish paediatric reference values and to provide standardisation of the application of CMR in children, more research is required. Currently, there is a shortage of (universal) paediatric normative datasets, like parametric mapping and tissue characterisation.…”

Section: Future Perspectivesmentioning

confidence: 99%

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Cardiac MRI in diagnosis, prognosis, and follow-up of hypertrophic cardiomyopathy in children: current perspectives

Spaapen,

Bohte,

Slieker

et al. 2024

British Journal of Radiology

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Hypertrophic Cardiomyopathy (HCM) is an inherited myocardial disease characterised by left ventricular hypertrophy, which carries an increased risk of life-threatening arrhythmias and sudden cardiac death. The age of presentation and the underlying aetiology have a significant impact on the prognosis and quality of life of children with HCM, as childhood-onset HCM is associated with high mortality risk and poor long-term outcomes. Accurate cardiac assessment and identification of the HCM phenotype are therefore crucial to determine the diagnosis, prognostic stratification, and follow-up. Cardiac magnetic resonance (CMR) is a comprehensive evaluation tool capable of providing information on cardiac morphology and function, flow, perfusion, and tissue characterisation. CMR allows to detect subtle abnormalities in the myocardial composition and characterise the heterogeneous phenotypic expression of HCM. In particular, the detection of the degree and extent of myocardial fibrosis, using late-gadolinium enhanced sequences or parametric mapping, is unique for CMR and is of additional value in the clinical assessment and prognostic stratification of paediatric HCM patients. Additionally, childhood HCM can be progressive over time. The rate, timing, and degree of disease progression vary from one patient to the other, so close cardiac monitoring and serial follow-up throughout the life of the diagnosed patients is of paramount importance. In this review, an update of the use of CMR in childhood HCM is provided, focussing on its clinical role in diagnosis, prognosis, and serial follow-up.

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Section: Cmr For Family Screeningsupporting

confidence: 68%

Section: Future Perspectivesmentioning

confidence: 99%

Cardiac MRI in diagnosis, prognosis, and follow-up of hypertrophic cardiomyopathy in children: current perspectives

Spaapen,

Bohte,

Slieker

et al. 2024

British Journal of Radiology

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“…Syncope commonly occurs in one of four patients with HCM but is difficult to estimate for multiple causes, such as supraventricular arrhythmia, sinus node dysfunction and complete heart block [ 15 ]. Several studies have shown that unexplained syncope is a marker for an increased risk of SCD [ 7 , 10 , 13 , 16 ]. Both the ACCF/AHA guidelines (Class IIa) and the ESC guidelines include unexplained syncope in ICD decision-making.…”

Section: Unexplained Syncopementioning

confidence: 99%

Risk factors of sudden cardiac death in hypertrophic cardiomyopathy

Hong

2021

Current Opinion in Cardiology

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Purpose of review Hypertrophic cardiomyopathy (HCM) is one of the leading causes of sudden cardiac death (SCD) in younger people and athletes. It is crucial to identify the risk factors for SCD in individuals with HCM. This review, based on recent systematic literature studies, will focus on the risk factors for SCD in patients with HCM. Recent findings An increasing number of studies have further explored the risk factors for SCD in patients with HCM, and new risk markers have emerged accordingly. In addition, more accurate SCD risk estimation and stratification methods have been proposed and continuously improved. Summary The identification of independent risk factors for HCM-related SCD would likely contribute to risk stratification. However, it is difficult to predict SCD with absolute certainty, as the annual incidence of SCD in adult patients with HCM is approximately 1%. The review discusses the established risk factors, such as a family history of SCD, unexplained syncope and some new risk factors. Taken together, the findings of this review demonstrate that there is a need for further research on individual risk factors and that SCD risk stratification in HCM patients remains a clinical challenge.

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Diagnosis of decreased segmental deformation of the left ventricular myocardium in a teenager at the early stage of hypertrophic cardiomyopathy (clinical observation)

Groznova,

Tarasova,

Verchenko

et al. 2024

Medicinskij alfavit

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The article presents a clinical observation that revealed a decrease in segmental deformation of the left ventricular myocardium in a 15-year-old teenager at the early stage of asymmetric non-obstructive hypertrophic cardiomyopathy (HCM). To assess myocardial systolic function, the following were used: ejection fraction and shortening of the left ventricle, as well as indicators of global and segmental myocardial deformation, determined by echocardiographic study using the 2D speckle-tracking method. There was no change in ejection fractions and shortening of the left ventricle, global longitudinal deformation of the myocardium, but there was a decrease in longitudinal and circular deformation in individual segments of the left ventricle, which, in general, was the basis for prescribing cardioprotective therapy.

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Newer risk assessment strategies in hypertrophic cardiomyopathy

Cited by 3 publications

References 63 publications

Cardiac MRI in diagnosis, prognosis, and follow-up of hypertrophic cardiomyopathy in children: current perspectives

Cardiac MRI in diagnosis, prognosis, and follow-up of hypertrophic cardiomyopathy in children: current perspectives

Risk factors of sudden cardiac death in hypertrophic cardiomyopathy

Diagnosis of decreased segmental deformation of the left ventricular myocardium in a teenager at the early stage of hypertrophic cardiomyopathy (clinical observation)

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