Newest applications of molecularly imprinted polymers for extraction of contaminants from environmental and food matrices: A review

Speltini, Andrea; Scalabrini, Andrea; Maraschi, Federica; Sturini, Michela; Profumo, Antonella

doi:10.1016/j.aca.2017.04.042

Cited by 284 publications

(116 citation statements)

References 112 publications

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“…The shape, size and chemical functionality of MIPs binding sites are complementary to the target analyte that interacts with polymers through a hydrogen bond, ion-exchange, electrostatic interaction, etc. MIPs exhibit high selectivity, sensitivity, stability and binding capacity [20]. The notable advantages of MIPs which have attracted attention from researchers and engineers are the low cost of production and their potential for use in separation and detection applications [21,22].…”

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confidence: 99%

Florfenicol Binding to Molecularly Imprinted Polymer Nanoparticles in Model and Real Samples

et al. 2020

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A simple and straightforward technique for coating microplate wells with molecularly imprinted polymer nanoparticles (nanoMIPs) to develop assays similar to the enzyme-linked immunosorbent (ELISA) assay to determine and quantify florfenicol (FF) in real food samples such as liquid milk and salmon muscle is presented here. The nanoMIPs were synthesized by a solid-phase approach with an immobilized FF (template) and characterized using dynamic light scattering, a SPR-2 biosensor system and transmission electron microscopy. Immobilization of nanoMIPs was conducted by preparing a homogenous solution of FF-nanoMIPs in water mixed with polyvinyl alcohol (PVA) 0.2% (w/v) in each well of a microplate. The detection of florfenicol was achieved in competitive binding experiments with a horseradish peroxidase−florfenicol (FF-HRP) conjugate. The assay made it possible to measure FF in buffer and in real samples (liquid milk and salmon muscle) within the range of 60−80 and 90-100 ng/mL, respectively. The immobilized nanoMIPs were stored for six weeks at room temperature and at 5 • C. The results indicate good signal recovery for all FF concentrations in spiked milk samples, without any detrimental effects to their binding properties. The high affinity of nanoMIPs and the lack of a requirement for cold chain logistics make them an attractive alternative to traditional antibodies used in ELISA.with florfenicol (FF) being the main antibiotic used (52%), followed by oxytetracycline, flumequine and oxolinic acid (44%, 1% and 1%, respectively) [5,6]. FF, a fluorinated derivative of thiamphenicol, is a new generation of fenicol drugs [7]. Apart from in the aquaculture industry, FF is widely used as chloramphenicol alternative to prevent and treat bacterial diseases in pigs [8], bovine [9], poultry [10] and animal edible tissues [11]. Several countries adopted maximum permissible residue limits (MRLs) of antibiotics in foods of animal origin, such as meat, milk and eggs [12]. In Chile, the maximum permissible residue limit of FF in muscle and skin of salmon is 1000 µg/kg [13]. At present, no MRL has been set for FF in milk. It is however of vital importance to develop a reliable method for FF analysis in milk products to avoid potential harmful effects to consumers [14]. Therefore, there is a demand for relevant sensitive, selective, fast and inexpensive analytical protocols from legislation, health authorities and companies operating in the food market [15]. Various analytical techniques have been reported for the analysis of FF, including high performance liquid chromatography, gas chromatography, liquid chromatography-Tandem mass spectrometry [16], gas chromatography-Mass spectrometry [17], and enzyme-linked immunosorbent assay (ELISA) [18]. The manufacture of molecular imprinting polymers (MIP) can be very valuable for those selective and sensitive methods that are needed. Molecular impression is a technique for producing in a polymer matrix selective binding sites that recognize a particular molecule. These polymers are very sta...

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Florfenicol Binding to Molecularly Imprinted Polymer Nanoparticles in Model and Real Samples

et al. 2020

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“…Molecularly imprinted polymers (MIPs), the manufactured sorbents that show particular official of target sub-atomic, have been broadly used for the extraction of explicit mixes [115,116]. Sorbent requires to be mixed with test to get homogeneous blend in MSPD.…”

Section: Recent Advances In Mspd Sorbentmentioning

confidence: 99%

Mi-Spe, M-Spe and M-SPD Recent Application on Solid Phase Extraction for Compound Extraction of Complex Matrices

Gopalan

Hasanah

2019

Int J App Pharm

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Solid Phase Extraction is a method used for extraction, purification of compounds contained in complex matrices and purification of samples in the fields of industry, pharmacy, and toxicology analysis. This review represents the recent advances of solid phase extraction from different mode of separation which are the most commonly used in recent days such as molecular imprinting solid phase extraction (MISPE), magnetic solid phase extraction (MSPE) and matrix solid phase dispersion (MSPD). In this review, the applications of MISPE in the analysis of agrochemicals such as herbicides, fungicides and insecticides are summarized. This review also states preparation of various magnetic composites (MSPE) based on graphene and its application as adsorbents in pre concentrating natural mixes, organic macromolecules. Besides this, this review summarizes the application of MSPD in biological, food, and environmental samples, including both organic and inorganic analyte.

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“…They are formed by the copolymerization of functional monomers employing crosslinking agents and radical initiator in the presence of the template molecule. Among the variables involved in the synthesis process are the molar proportions between the template molecule, the functional monomer, the type and amount of solvent, the crosslinking reagents and the radical initiator, the time and the polymerization process .…”

Section: New Materialsmentioning

confidence: 99%

“…After the synthesis the template molecule is removed by either chemical or physical methods forming in the polymer the molecular recognition sites with size, shape, and functionalities similar to the compound of interest. The use of MIPs has grown significantly and has many advantages as selective extractive phases due to the ability to recognize and identify the analytes of interest, reducing or even eliminating the interferences of complex matrices .…”

Section: New Materialsmentioning

confidence: 99%

Recent trends in sorption‐based sample preparation and liquid chromatography techniques for food analysis

2018

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The accelerated rising of the world's population increased the consumption of food, thus demanding more rigors in the control of residue and contaminants in food-based products marketed for human consumption. In view of the complexity of most food matrices, including fruits, vegetables, different types of meat, beverages, among others, a sample preparation step is important to provide more reliable results when combined with HPLC separations. An adequate sample preparation step before the chromatographic analysis is mandatory in obtaining higher precision and accuracy in order to improve the extraction of the target analytes, one of the priorities in analytical chemistry. The recent discovery of new materials such as ionic liquids, graphene-derived materials, molecularly imprinted polymers, restricted access media, magnetic nanoparticles, and carbonaceous nanomaterials, provided high sensitivity and selectivity results in an extensive variety of applications. These materials, as well as their several possible combinations, have been demonstrated to be highly appropriate for the extraction of different analytes in complex samples such as food products. The main characteristics and application of these new materials in food analysis will be presented and discussed in this paper. Another topic discussed in this review covers the main advantages and limitations of sample preparation microtechniques, as well as their off-line and on-line combination with HPLC for food analysis.

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Newest applications of molecularly imprinted polymers for extraction of contaminants from environmental and food matrices: A review

Cited by 284 publications

References 112 publications

Florfenicol Binding to Molecularly Imprinted Polymer Nanoparticles in Model and Real Samples

Florfenicol Binding to Molecularly Imprinted Polymer Nanoparticles in Model and Real Samples

Mi-Spe, M-Spe and M-SPD Recent Application on Solid Phase Extraction for Compound Extraction of Complex Matrices

Recent trends in sorption‐based sample preparation and liquid chromatography techniques for food analysis

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