Newinsights into Melatonin Regulation of Cancer Growth

Blask, David E.; Sauer, Leonard A.; Dauchy, Robert T.; Holowachuk, Eugene W.; Ruhoff, Mary S.

doi:10.1007/0-306-46814-x_38

Cited by 17 publications

(13 citation statements)

References 10 publications

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“…Finally, this conclusion can be used to design and develop the electrical display devices used before sleep that cannot stimulate alerting or stress and suppress melatonin production. Melatonin suppression by light at night increases the risk for more serious diseases such as breast cancer [12]. In addition, artificial light technology is used in the design of more effective lighting at novel house or workplace with no effect on human physiology and health maintenance.…”

Section: B Human Saliva Melatoninmentioning

confidence: 99%

“…Plitnick et al (2010) showed that red light and blue light at nighttime can increase the beta-wave of electroencephalogram (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) and stimulate alertness and momentary mood and reduce sleepiness [5]. Cajochen et al (2005) showed that light at 460 nm stimulate alertness, effect on thermoregulation and heart rate, suppress melatonin production more than light at 550 nm [6].…”

Section: Introductionmentioning

confidence: 99%

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Effects of LED-backlit computer screen and emotional selfregulation on human melatonin production

Sroykham

Wongsawat

2013

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Melatonin is a circadian hormone transmitted via suprachiasmatic nucleus (SCN) in the hypothalamus and sympathetic nervous system to the pineal gland. It is a hormone necessary to many human functions such as immune, cardiovascular, neuron and sleep/awake functions. Since melatonin enhancement or suppression is reported to be closely related to the photic information from retina, in this paper, we aim further to study both the lighting condition and the emotional self-regulation in different lighting conditions together with their effects on the production of human melatonin. In this experiment, five participants are in three light exposure conditions by LED backlit computer screen (No light, Red light (∼650nm) and Blue light (∼470nm)) for 30 minute (8-8:30pm), then they are collected saliva both before and after the experiments. After the experiment, the participants are also asked to answer the emotional self-regulation questionnaire of PANAS and BRUMS regarding each light exposure condition. These results show that positive mood mean difference of PANAS between no light and red light is significant with p=0.001. Tension, depression, fatigue, confusion and vigor from BRUMS are not significantly changed while we can observe the significant change in anger mood. Finally, we can also report that the blue light of LED-backlit computer screen significantly suppress melatonin production (91%) more than red light (78%) and no light (44%).

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Section: B Human Saliva Melatoninmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of LED-backlit computer screen and emotional selfregulation on human melatonin production

Sroykham

Wongsawat

2013

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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“…Exposure to blue light at night time can lead to suppression of melatonin secretion which disrupts the circadian clock and may cause adverse consequences on mental, physical health, and sleep . The disruption of circadian rhythm is associated with mood disorders, breast cancer, obesity and chronic diseases, heart disease, high blood pressure, and other cardiovascular problems . Conversely, the reduction in blue‐enriched light during daytime hours can increase daytime melatonin levels, which may lead to sleepiness, mood and cognitive deficits …”

mentioning

confidence: 99%

Modelling the effect of commercially available blue‐blocking lenses on visual and non‐visual functions

Alzahrani

Khuu

Roy

2020

Clinical and Experimental Optometry

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Background: Blue-blocking lenses (BBLs) are marketed as providing retinal protection from acute and cumulative exposure to blue light over time. The selective reduction in visible wavelengths transmitted through BBLs is known to influence the photosensitivity of retinal photoreceptors, which affects both visual and non-visual functions. This study measured the spectral transmittance of BBLs and evaluated their effect on blue perception, scotopic vision, circadian rhythm, and protection from photochemical retinal damage. Methods: Seven different types of BBLs from six manufacturers and untinted control lenses with three different powers (+2.00 D, −2.00 D and Plano) were evaluated. The whiteness index of BBLs used in this study was calculated using Commission International de l'Eclairage (CIE) Standard Illuminates D65, and CIE 1964 Standard with a 2 Observer. The protective qualities of BBLs and their effect on blue perception, scotopic vision, and circadian rhythm were evaluated based on their spectral transmittance, which was measured with a Cary 5,000 UV-Vis-NIR spectrophotometer. Results: BBLs were found to reduce blue light (400-500 nm) by 6-43 per cent, providing significant protection from photochemical retinal damage compared to control lenses (p ≤ 0.05). All BBLs were capable of reducing the perception of blue colours, scotopic sensitivities and circadian sensitivities by 5-36 per cent, 5-24 per cent, and 4-27 per cent, respectively depending on the brand and power of the lens. Conclusion: BBLs can provide some protection to the human eye from photochemical retinal damage by reducing a portion of blue light that may affect visual and non-visual performances, such as those critical to scotopic vision, blue perception, and circadian rhythm.

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“…It has been suggested that melatonin and its derivatives might have a variety of clinical applications as a supplement to combat the delayed sleep phase syndrome (Oldani et al, 1994;Mulchahey et al, 2004;Skocbat et al, 1998;Rodenbeck et al, 1998), jet lag (Arendt et al, 1997) and seasonal disorders (Rosenthal et al, 1986), and as a hypnotic agent in modulation of the sleep-wake cycle (Dollins et al, 1994;Garfinkel et al, 1995;Reid et al, 1996). It can retard the aging process (Bonilla et al, 2002) and prevent the formation of cancers (Reiter et al, 1999;Blask et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

A validated sensitive HPLC‐MS/MS method for quantification of a potential hypnotic drug MT502 and its application to a pharmacokinetic study in rat

Zhang

Cheng

Wan

et al. 2015

Biomedical Chromatography

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A rapid, sensitive HPLC-MS/MS method was established and validated to assay the concentration and pharmacokinetic profile of MT502, a promising hypnotic drug. The plasma sample was treated by a liquid-liquid extraction and separated on a kromasil C18 column at an isocratic flow rate of 0.3 mL/min using methanol and 0.1% formic acid in water (75:25, v/v) as mobile phase. The mass spectrometric detection was carried out using a triple-quadrupole system via positive electrospray ionization. Multiple reaction monitoring was used for quantitation of m/z transitions from 261 to 188 for MT502 and from 247 to 188 for MT501 (internal standard). Good linearity was achieved over the concentration range of 1-1000 ng/mL and 10-5000 ng/mL with lower limit of quantification of 0.30 and 0.80 ng/mL. The intra- and inter-day precisions, accuracy, recovery and stability were satisfactory for the concentration test. The above method can be used for a pharmacokinetic study at doses of 1, 5 and 20 mg/kg. Results indicated that MT502 had rapid absorption, rapid elimination and linear pharmacokinetic properties within the range of the tested intragastric dose. This developed HPLC-MS/MS method was successfully applied to a pharmacokinetic study of MT502 for the first time and was demonstrated to be simple and sensitive.

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Newinsights into Melatonin Regulation of Cancer Growth

Cited by 17 publications

References 10 publications

Effects of LED-backlit computer screen and emotional selfregulation on human melatonin production

Effects of LED-backlit computer screen and emotional selfregulation on human melatonin production

Modelling the effect of commercially available blue‐blocking lenses on visual and non‐visual functions

A validated sensitive HPLC‐MS/MS method for quantification of a potential hypnotic drug MT502 and its application to a pharmacokinetic study in rat

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