2023
DOI: 10.3390/app13148170
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Newly Discovered Irbesartan Disinfection Byproducts via Chlorination: Investigating Potential Environmental Toxicity

Abstract: Irbesartan belongs to the Sartan family, whose members are used in the treatment of arterial hypertension and kidney disease among patients with hypertension and type 2 diabetes mellitus as part of a treatment based on antihypertensive drugs. This drug has reached surface waters, accumulating to the extent of being considered an emerging pollutant, along with other substances from the same class. Wastewater treatment plants, which constitute the main environmental source of this compound, fail to completely re… Show more

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Cited by 3 publications
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“…Sartans such as Irbesartan and Losartan tend to decrease in concentration following water disinfection treatments, resulting in a decrease of up to 75% for Irbesartan and 62% for Losartan [18]. This often leads to the production of more toxic degradation byproducts (DP) than the parent molecule [19]. These byproducts have been the subject of study in recent years, with some studies considering valsartan acid, produced by the oxidation of different sartans, as an indicator of sartan pollution [20].…”
Section: Introductionmentioning
confidence: 99%
“…Sartans such as Irbesartan and Losartan tend to decrease in concentration following water disinfection treatments, resulting in a decrease of up to 75% for Irbesartan and 62% for Losartan [18]. This often leads to the production of more toxic degradation byproducts (DP) than the parent molecule [19]. These byproducts have been the subject of study in recent years, with some studies considering valsartan acid, produced by the oxidation of different sartans, as an indicator of sartan pollution [20].…”
Section: Introductionmentioning
confidence: 99%