Newly discovered KI, WU, and Merkel cell polyomaviruses: No evidence of mother-to-fetus transmission

Sadeghi, Mohammadreza; Riipinen, Anita; Väisänen, Elina; Chen, Tingting; Kantola, Kalle; Surcel, Heljä Marja; Karikoski, Riitta; Taskinen, Helena; Söderlund‐Venermo, Maria; Hedman, Klaus

doi:10.1186/1743-422x-7-251

Cited by 29 publications

(21 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18 Foetal tissues were also negative for WU and KI viruses. 25 In this study WU and KI viruses were not found in urine, plasma and respiratory samples collected during pregnancy. KIPyV DNA was detected in two plasma samples, but not in urine and respiratory samples from control, non pregnant women.…”

Section: Discussionmentioning

confidence: 72%

Novel human polyomaviruses in pregnancy: Higher prevalence of BKPyV, but no WUPyV, KIPyV and HPyV9

Csoma

Sápy

Mészáros

et al. 2012

Journal of Clinical Virology

View full text Add to dashboard Cite

26Background: Immunosuppression due to pregnancy may lead to higher susceptibility to 27 infections and reactivation of latent infections, such as BK polyomavirus (BKPyV). There is 28 lack of information about the prevalence of novel human polyomavirus 9 (HPyV9), WU 29 (WUPyV) and KI (KIPyV) during pregnancy. 30Objectives: To study whether pregnancy results in higher prevalence of HPyV9, WUPyV, 31KIPyV and their correlation with BKPyV. 32Study design: Plasma, urine and throat swab samples from 100 pregnant and 100 non 33 pregnant women were screened for the presence of WUPyV, KIPyV, HPyV9 and BKPyV by 34 PCR. 35Results: No WUPyV DNA was detected in plasma, urine and respiratory samples from 36

show abstract

Section: Discussionmentioning

confidence: 72%

Novel human polyomaviruses in pregnancy: Higher prevalence of BKPyV, but no WUPyV, KIPyV and HPyV9

Csoma

Sápy

Mészáros

et al. 2012

Journal of Clinical Virology

View full text Add to dashboard Cite

show abstract

“…MCC is a cutaneous cancer, and MCPyV has been recovered from normal skin of up to 40% of healthy adult volunteers, which would support cutaneous transmission of the virus (13,26). MCPyV was not detected in 535 fetal autopsy samples, and thus vertical transmission from mother to fetus does not occur or is very rare (24). However, this does not exclude the possibility of perinatal horizontal transmission at the time of birth.…”

Section: Discussionmentioning

confidence: 98%

Age-Specific Seroprevalence of Merkel Cell Polyomavirus, BK Virus, and JC Virus

Viscidi

Rollison

Sondak

et al. 2011

Clin. Vaccine Immunol.

166

146

View full text Add to dashboard Cite

We produced capsids of Merkel cell polyomavirus (MCPyV) in a baculovirus expression system and developed a virus-like particle (VLP) enzyme-linked immunosorbent assay (ELISA). To determine age-specific seroprevalence, serum samples were collected from 947 individuals attending hospital outpatient clinics and ranging in age from 1 to 93 years. To evaluate the association between exposure to MCPyV and Merkel cell cancer (MCC), plasma samples were obtained from 33 MCC patients and 37 controls. MCPyV seroprevalence was 45% in children under 10 years of age, increased to 60% in the next decade of life, and peaked at 81% among those 60 to 69 years of age. Levels of MCPyV capsid antibodies were positively correlated with age (P ‫؍‬ 0.007). Virus specificity of MCPyV seroreactivity was supported by competitive inhibition of reactivity by MCPyV VLPs and not by BK polyomavirus (BKPyV) VLPs. MCPyV seroprevalence was greater among MCC patients (91%) than controls (68%; age-adjusted P value, 0.32); the mean level of MCPyV antibodies was also greater (P ‫؍‬ 0.04). The age-specific seroprevalence of MCPyV shares with previously known polyomaviruses, BKPyV and JC polyomavirus (JCPyV), evidence of widespread exposure in human populations beginning early in life. MCPyV age-specific seroprevalence also has unique features. Seroprevalence among children is higher than that of JCPyV but lower than that of BKPyV. Among older adults, MCPyV seroprevalence remains high, while that of BKPyV declines and that of JCPyV continues to rise. In agreement with results from other studies, we found an association between MCPyV seropositivity and MCC, and higher levels of serum MCPyV capsid antibodies in MCC patients than in controls.Merkel cell polyomavirus (MCPyV), a new human polyomavirus, was recently discovered by molecular techniques in Merkel cell carcinoma (MCC) (11), a rare and aggressive skin tumor (20,22). Studies from North America and Europe have detected MCPyV DNA by PCR in 69 to 100% of MCC tumors (1,9,11,13,14,17,25). The virus has also been detected in rare instances and in low copy numbers in cutaneous, gastrointestinal, and respiratory tract samples from healthy individuals (2,11,15). Little is known about the natural history of MCPyV infection in human populations. Serological assays can reveal the extent of past exposure to a virus and provide insights into its epidemiology. We and others have developed virus-like particle (VLP)-based enzyme-linked immunosorbent assays (ELISAs) to measure antibodies to various human and animal polyomaviruses (10, 27, 31). Polyomavirus VLPs are empty viral capsids produced by expression of the gene for the major capsid protein, VP1, in a eukaryotic expression system. VLPs resemble native virions morphologically and retain their immunological properties, including the ability to bind antiviral capsid antibodies. We now report the development of a VLP-based ELISA to detect antibodies to MCPyV and its application for comparison of the age-specific seroprevalence of MCPyV to those of two other huma...

show abstract

“…Seroprevalence of 50-95% is reported in adults (7,(12)(13)(14)(25)(26)(27)(28)(29). The age-specific seroprevalence of MCPyV (Fig.…”

Section: Serologymentioning

confidence: 99%

Human Merkel cell polyomavirus: virological background and clinical implications

Coursaget

Samimi

Nicol

et al. 2013

APMIS

View full text Add to dashboard Cite

The Merkel cell polyomavirus (MCPyV), identified in humans in 2008, is associated with a relatively rare but aggressive neuroendocrine skin cancer, the Merkel cell carcinoma (MCC). MCC incidence is increasing due to the advancing age of the population, the increase in damaging sun exposure and in the number of immunocompromised individuals. MCPyV must be considered as the etiological agent of MCC and thus is the first example of a human oncogenic polyomavirus. MCPyV infection is common, and seroprevalence studies indicate that widespread exposure begins early in life. The majority of adults have anti-MCPyV antibodies and there is a growing body of evidence that healthy human skin harbors resident or transient MCPyV suggesting that MCPyV infection persists throughout life. However, the mode of transmission, the host cells, and the latency characteristics of this virus remain to be elucidated. In addition, it is still not clear whether MCPyV is associated with diseases or lesions other than Merkel cell carcinoma. The etiologic role of MCPyV in MCC opens up opportunities to improve the understanding of this cancer and to potentially improve its treatment.

show abstract

Newly discovered KI, WU, and Merkel cell polyomaviruses: No evidence of mother-to-fetus transmission

Cited by 29 publications

References 33 publications

Novel human polyomaviruses in pregnancy: Higher prevalence of BKPyV, but no WUPyV, KIPyV and HPyV9

Novel human polyomaviruses in pregnancy: Higher prevalence of BKPyV, but no WUPyV, KIPyV and HPyV9

Age-Specific Seroprevalence of Merkel Cell Polyomavirus, BK Virus, and JC Virus

Human Merkel cell polyomavirus: virological background and clinical implications

Contact Info

Product

Resources

About