Newly discovered mycoplasma isolated from patients infected with HIV

Mycoplasmal Infections Prevent Apoptosis and Induce Malignant Transformation of Interleukin-3-Dependent 32D Hematopoietic Cells

“…M. fermentans PG18 (ATCC 19989), incognitus (previously isolated from our laboratory [17]), and A25 (isolated from a patient with AIDS and to be reported separately), M. penetrans GTU-54 (previously isolated from our laboratory [16]), M. salivarium ATCC 23064, M. genitalium ATCC 33530, M. pneumoniae ATCC 15531, M. orale ATCC 23714, and M. pirum (kindly provided by J. G. Tully, National Institute of Allergy and Infectious Diseases, National Institutes of Health) were grown aerobically in SP-4 broth medium. The 32D cell line (kindly provided by Jaclyn H. Pierce, National Cancer Institute, National Institutes of Health) is an IL-3-dependent, nontumorigenic cell line that has an undifferentiated myeloid phenotype and a normal diploid karyotype.…”

Identification of two glycosylated components of Mycoplasma penetrans: a surface-exposed capsular polysaccharide and a glycolipid fraction

“…In addition, it was shown for M. dispar (Almeida et al, 1992) that there is a correlation between the presence of capsule and the resistance of mycoplasma cells to phagocytosis. Mycoplasma penetrans was only recently isolated, initially from HIV-infected patients, and has unique morphology (Lo et al, 1991). It is cytopathic and capable of adhesion to, and invasion of, mammalian epithelial cells (Andreev et al, 1995;Giron et al, 1996;Lo et al, 1993).…”

Heat shock protein of Mycoplasma salivarium and Mycoplasma orale strains isolated from HIV-seropositive patients.

“…Many research groups have suggested that infections by mycoplasma species are cofactors in the seroconversion of AIDS in the HIV(‫)ם‬ group 7,9,11,14,18,19,24) . As one such cofactors, superantigen produced by specific mycoplasma species is known to play a role in the immunodeficiency process in HIV(‫)ם‬ patients 4,9,11,15,16) . However, in this study, we found that the strains of M. salivarium, M. orale and unidentified mycoplasma species we examined did not produce superantigen.…”