Newly-identified blood biomarkers of neurological damage are correlated with infarct volume in patients with acute ischemic stroke

O’Connell, Grant; Smothers, Christine G.; Gandhi, Shivam

doi:10.1016/j.jocn.2021.10.015

Cited by 9 publications

(5 citation statements)

References 34 publications

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“…All the patients were presented in the 4.5 hours window with 67% treated in the first 3 hours. The score of NIHSS decreased to a median of 10.5 (8)(9)(10)(11)(12)(13)(14)(15)(16) after 24 hours. And further to a median of 8(3-15) after 3 months.…”

Section: Resultsmentioning

confidence: 95%

“…More ischemic tissue or ischemia in a critical location (such as the motor area 4, the posterior limb of the internal capsule, or aphasia and its subtypes) corresponds to a higher NIHSS score. When carefully administered by a competent neurologist or nurse, NIHSS is a strong tool in diagnosing, follow up, monitoring Thrombolysis with clinical-diffusion mismatch may be employed in lieu of perfusion imaging with equivalent outcomes [8].…”

Section: Discussionmentioning

confidence: 99%

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Comparative Retrospective study of NIHSS score before and after thrombolytic therapy in stroke patients

Nada

Kasem²,

Fahim³

et al. 2022

Benha Journal of Applied Sciences

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A stroke is "acute neurologic dysfunction of vascular origin with abrupt (within seconds) or at least fast (within hours) onset of symptoms and signs correlating to the involvement of specific regions in the brain." Strokes may be either ischemic or hemorrhagic. This research set out to compare NIHSS scores before and after rTPA, as well as to look at other variables that could have an effect on the result of rTPA. Methods: Fifty patients who had had an acute cerebrovascular stroke and been treated with RTPA were included in this retrospective analysis. Electrocardiogram (ECG), Echocardiogram (Echo), and Doppler ultrasound of the carotid arteries will be performed on all patients. Standard blood tests include a complete blood count (CBC), a lipid profile, a random blood sugar and glycosylated haemoglobin, and a hematocrit measurement (Hba1c). Early neurological progress; the results. AKA: high blood pressure. Ratio normalised on a global scale; abbreviated INR. Interquartile range (IQR) The M-RS is the modified Rankin scale. What we call the "stroke scale" at the National Institutes of Health. On bivariate analysis, hemorrhagic transformation was linked to factors such as a prior history of hypertension (8(88.9%)/1(11.1%), p= 0.034*), a higher NIHSS at presentation (16(13.5-21.5) against 13(11-16), p=0.025*), and a higher NIHSS after 24 hours (20(15-25) versus 10(7-15), p=0.000**). Initial National Institutes of Health Stroke Scale (NIHSS) was an independent predictor, with an increased risk of hemorrhagic transformation of 1.223% (95% CI 1.030% to 1.451%) (p=0.021) for each additional unit, and hypertensive patients tended to experience hemorrhagic transformation (AOR= 9.529% (95% CI 0.936% to 97.56%), p=0.058). When patients are properly chosen, intravenous rtPA is effective. There is no significant difference in the results in the first 3 hours versus extra 1.5 hour. It works just as well in the frontal as it does in the backal circulation. The National Institute of Health Stroke Scale (NIHSS) is an excellent clinical instrument for predicting the severity, speed of recovery, hemorrhagic transformation, and death of stroke.

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Section: Resultsmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Comparative Retrospective study of NIHSS score before and after thrombolytic therapy in stroke patients

Nada

Kasem²,

Fahim³

et al. 2022

Benha Journal of Applied Sciences

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“…Recently, neuron-specific proteins were linked to infarct volume through analyses of eight brain-enriched candidate proteins (GFAP, MBP, β-synuclein, OPALIN, MT-3, SNAP-25, KIF5A, MOBP) [ 154 ]. This study included 43 patients with IS and blood was drawn immediately after hospital admission.…”

Section: Resultsmentioning

confidence: 99%

“…It is also worth noting that the most significant correlation was observed for four neuron-specific proteins (MT-3, SNAP-25, KIF5A, β-synuclein). The strongest correlation with infarct volume was given by a combination of these four proteins [ 154 ].…”

Section: Resultsmentioning

confidence: 99%

Advances in development of biomarkers for brain damage and ischemia

Karimova,

Rostami,

Chubarev

et al. 2024

Mol Biol Rep

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Acquired brain injury is an urgent situation that requires rapid diagnosis and treatment. Magnetic resonance imaging (MRI) and computed tomography (CT) are required for accurate diagnosis. However, these methods are costly and require substantial infrastructure and specialized staff. Circulatory biomarkers of acute brain injury may help in the management of patients with acute cerebrovascular events and prevent poor outcome and mortality. The purpose of this review is to provide an overview of the development of potential biomarkers of brain damage to increase diagnostic possibilities. For this purpose, we searched the PubMed database of studies on the diagnostic potential of brain injury biomarkers. We also accessed information from Clinicaltrials.gov to identify any clinical trials of biomarker measurements for the diagnosis of brain damage. In total, we present 41 proteins, enzymes and hormones that have been considered as biomarkers for brain injury, of which 20 have been studied in clinical trials. Several microRNAs have also emerged as potential clinical biomarkers for early diagnosis. Combining multiple biomarkers in a panel, along with other parameters, is yielding promising outcomes.

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“…S100B is not normally present in the peripheral circulation but is released following stroke and has been commonly implicated in brain injury. Elevated levels of serum GFAP have been found in ischemic stroke [93] and intracranial haemorrhage e [65] with lipocalin-2 increased in the blood of VaD [94] and AD patients [95] . Though activated astrocytes have been reported to contribute to the breakdown of the BBB [96] , the exact pathogenic mechanisms involving lipocalin-2 and its diagnostic capability in cognitive impairment is unclear.…”

Section: Discussionmentioning

confidence: 99%

Fluid biomarkers of the neurovascular unit in cerebrovascular disease and vascular cognitive disorders: A systematic review and meta-analysis

Hansra,

Jayasena,

Hosoki

et al. 2024

Cerebral Circulation - Cognition and Behavior

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Newly-identified blood biomarkers of neurological damage are correlated with infarct volume in patients with acute ischemic stroke

Cited by 9 publications

References 34 publications

Comparative Retrospective study of NIHSS score before and after thrombolytic therapy in stroke patients

Comparative Retrospective study of NIHSS score before and after thrombolytic therapy in stroke patients

Advances in development of biomarkers for brain damage and ischemia

Fluid biomarkers of the neurovascular unit in cerebrovascular disease and vascular cognitive disorders: A systematic review and meta-analysis

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