Newly isolated sporopollenin microcages from Cedrus libani and Pinus nigra as carrier for Oxaliplatin; xCELLigence RTCA-based release assay

Mujtaba, Muhammad; Yılmaz, Bahar; Cansaran-Duman, Demet; Akyüz, Lalehan; Yangın, Sevcan; Kaya, Murat; Çeter, Tali̇p; Khawar, Khalid Mahmood

doi:10.1007/s00289-020-03531-7

Cited by 5 publications

(2 citation statements)

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“…The aliphatic C=C stretch band of sporopollenin structures was detected at 1604 cm −1 [18]. Literature comparisons show that structures isolated from C. libani pollen consist of sporopollenin [19].…”

Section: Ft-ir Spectroscopy Analysismentioning

confidence: 95%

Encapsulation of Vitamin D in the Exine-Alginate-Chitosan Microcapsule System

DUYSAK,

SARGİN

2024

KONJES

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The insufficiency of vitamin D, resulting from inadequate exposure to sunlight and/or insufficient dietary intake, remains a major public health concern on a global scale. In this study, vitamin D2 and D3 were microencapsulated using sporopollenin exine microcapsules extracted from Cedrus libani pollens. After loading vitamin D into the microcapsules, they were coated with chitosan, an edible, biocompatible, and mucoadhesive polysaccharide, and alginate (a food additive agent coded E401). Exine microcapsules were extracted by microwave irradiation-assisted chemical method, and structural and morphological examination of exine structures was performed by FT-IR, TGA, SEM, and SEM-EDX analyses. After loading vitamin D into microcapsules in an ethanol medium, the loaded microcapsules were immobilised into the alginate matrix in a calcium chloride solution. D2 and D3 were loaded into 100 mg of sporopollenin exine microcapsules, resulting in loading efficiencies of 31.5 mg and 16.0 mg, respectively. The vitamin D release performance of the microcapsules was examined depending on time and temperature after they were coated with a thin chitosan layer. The release of the highest amount of vitamin D2 and D3 occurred at a temperature of 37°C. Encapsulating vitamin D molecules in chitosan and alginate creates a barrier against degrading environmental conditions, which helps prevent the loss of vitamin D biological activity. This can improve vitamin D dietary supplements' storage, preservation, and marketing requirements.

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Section: Ft-ir Spectroscopy Analysismentioning

confidence: 95%

Encapsulation of Vitamin D in the Exine-Alginate-Chitosan Microcapsule System

DUYSAK,

SARGİN

2024

KONJES

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“…India's forests are the fundamental repository for a plethora of fragrant plants. In India, plants are generally known to possess some medicinal properties [6,7]. Another report recorded that a total of 2500 plants are traditional medicine, of which 100 plants are used regularly.…”

Section: Introductionmentioning

confidence: 99%

Composition, antioxidant and anti-inflammatory activities of different polarity extracts of Anaphalis busua from the Himalayan terrain of Uttarakhand

et al. 2023

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The current study describes the analysis of the phytochemical composition and biological activities of various polarity extracts of the Anaphalis busua plant that was collected at an altitude of 1654 m in the Himalayan terrain of Uttarakhand, India. The extracts were prepared by the cold percolation method, which was then subjected to GC-MS for phytochemical analysis. A total of 31 compounds were identified that constituted 94.95% of the total methanolic extract. Mome inositol (31.03%) was identified as the main compound in the methanolic extract. Twenty-two compounds that comprise 68.24% of the total hexane extract were identified. Tetracontane (19.33%) was present in a significant proportion. The methanolic extract demonstrated potent antioxidant activity in terms of DPPH radical scavenging and metal chelating activity that have IC50 values of 81.71±1.334 and 11.26±0.005 µg/mL, respectively, compared to standards ascorbic acid and EDTA that have IC50 values at 12.71±0.02 and 11.36±0.06 µg/mL, respectively. The methanolic extract showed potent anti-inflammatory activity with an IC50 value of 24.10±0.09 µg/mL in comparison to standard diclofenac potassium with an IC50 value of 18.95±0.03 µg/mL. In vitro studies reveal that A. busua has a strong therapeutic potential and, if further explored, may prove to be a powerful antioxidant, anti-inflammatory, and cost-effective agent compared to synthetically derived agents from pharmaceutical industries.

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