News & Views in ... Nanomedicine

Abstract

This study aims to develop an amperometric glucose biosensor, based on carbon nanotubes material for reverse iontophoresis, fabricated by immobilizing a mixture of glucose oxidase (GOD) and multiwalled carbon nanotubes (MWCNT) epoxy-composite, on a planar screen-printed carbon electrode. MWCNT was employed to ensure proper incorporation into the epoxy mixture and faster electron transfer between the GOD and the transducer. Results showed this biosensor possesses a low detection potential (+500 mV), good sensitivity (4 μA/mM) and an excellent linear response range (r2 = 0.999; 0–4 mM) of glucose detection at +500 mV (versus Ag/AgCl). The response time of the biosensor was about 25 s. In addition, the biosensor could be used in conjunction with reverse iontophoresis technique. In an actual evaluation model, an excellent linear relationship (r2 = 0.986) was found between the glucose concentration of the actual model and the biosensor’s current response. Thus, a glucose biosensor based on carbon nanotube composites and incorporated with reverse iontophoresis function was developed.

An aqueous media based approach for the preparation of a biosensor platform composed of graphene oxide and Pt-black

“…This showed that the microbiosensors based on the GrOx/Pt-black nanocomposite could be readily used for physiological studies. The working potential (+500 mV) was chosen to ensure a desirable amperometric sensitivity and a low probability of oxidizing interference compounds (Claussen et al 2009; Shi 2011a, b; Sun et al 2010). The high sensitivity and the desirable selectivity as shown above justified the working potential used.…”

Extraction of Iron from the Rabbit Anterior Chamber with Reverse Iontophoresis

“…Thus, this method can be used to obtain chemical information from the body, which makes the clinical tests carried out without blood possible. Reverse iontophoresis (RI) is a technique that can be used to noninvasively extract polar substances through the skin by using a low electric current [ 22 ]. The mechanism of extraction involves either electromigration of charged species to the electrode of opposite polarity or electroosmosis of neutral molecules to the cathode or anode, or a combination of these two processes [ 23 ].…”