A bird's eye review was tried to select the bio-rational targets from known and novel plant-specific ones for the molecular design of modern herbicides, which exhibit efficient phytotoxicity at a low-use rate and preserve a good environment in the 21st century. In phytotoxic sites in the photosynthetic electron transport (PET) system discussed in the present article (Part 1), the generally called bleaching herbicides interfering with the biosynthesis of photosynthetic pigments, chlorophylls and carotenoids, and the biosynthesis of plastoquinone, were considered to be good models for the molecular design of modern herbicides. The PET itself was still considered as an interesting target site for new herbicides, although they need to exert their action in all green leaves of weeds to achieve herbicidal efficacy. Because these herbicides never form a tight binding with D1-protein, their use-rate cannot be expected to be as low as the herbicides inhibiting chlorophyll or branched amino-acid biosynthesis. Other herbicidal targets found in chloroplasts, namely ATP and NADPH formations, have already been omitted from the worldwide biorational molecular design program of herbicides targeting the PET system.Keywords: bleaching herbicides, modern herbicides, molecular design, photosynthetic electron transport, photosynthetic pigments and plastoquinone, plant-specific targets.kinds of new ALS-inhibiting herbicides that include the triazolinones, triazolopyrimidines and pyrimidyloxybenzoates, and more than 20 newer cyclic imide herbicides of Protox inhibitors in the decade of 1990. The recent phenoxypropionate acetyl-CoA carboxylase (ACCase) inhibitors are applied in the range of 100-150 g ha -1 ; the sulfonylurea and cyclic imide herbicides require an even lower amount, down to 5 g ha -1 , for some commercially active ones. Soil overloading with chemicals or leaching problems, resulting in a massive chemical impact or contamination of ground water, might not be an issue with such lower application doses.In the meantime, the expert genetic engineers have already produced many transgenic herbicide-resistant crops, taking a ca. 75% share in all genetically modified (GM) crops. In such situations, if skillful (agro)chemists design and synthesize only strong phytotoxic herbicidal compounds, they can ask their genetic engineers for selectivity (between crops and weeds) of their candidates, although the chemists should of course pay strong