News in Pathogenesis of Chronic Venous Insufficiency

Abstract

This review article is concentrating on the news in the pathophysiology of chronic venous insufficiency (CVD). Despite ongoing progress in understanding the molecular aspects of CVD the exact mechanism of its development remains unclear. Many different factors may play role in the pathogenesis of CVD, including changes in hydrostatic pressure, valvular incompetence, increased capillary permeability, endothelial dysfunction, activation of leukocytes, deep venous obstruction, capillary microthrombosis, ineffective function of calf muscle pump, biochemical and structural changes in the vessel wall, extracellular matrix alteration, and several other mechanisms. A better understanding of the pathophysiology is an important step in the finding of new potential treatment.

A novel view to varicose veins pathogenesis: Proteomic profiling suggests a pivotal role of extracellular matrix degradation

“…8 One of the recent theories proposes molecular changes leading to the histologic changes in the vessel wall and extracellular matrix (ECM) composition, thus venous wall weakening and subendothelial fibrosis. 9 However, the field still awaits deep biological profiling to gain insight into the pathology of VV.…”