This essay suggests that the more recent historiography of the history of science, with its focus on practice, opens up a field of investigation into the many interrelationships between the early modern “new sciences” and activities undertaken by early modern individuals called “architects,” whose range of activities was wider than that of their modern counterparts. Concerning the latter, it gives examples of the activities of Francesco di Giorgio, Vignola, Palladio, and Juan de Herrera, among others. It also discusses individuals who practiced both architecture and one or more of the new sciences – including Christopher Wren, Robert Hooke, Gérard Desargues, Guarino Guarini, Teofilo Galluccini, and François Blondel. Finally, it explores the practices and values common to both disciplines in the early modern period, including an emphasis on the visual and the practice of mathematics.