Newtonian and non-Newtonian blood flow in coiled cerebral aneurysms

Morales, Hernán G.; Larrabide, Ignacio; Geers, Arjan J.; Aguilar, M. L.; Frangi, Alejandro F.

doi:10.1016/j.jbiomech.2013.06.034

Cited by 93 publications

(59 citation statements)

References 25 publications

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“…Furthermore, aneurysm neck size overestimation due to 3D RA can lead to significantly different WSS results and a different flow structure classification. Other groups reported that the vascular anatomy has the greatest influence on the development of IA and subsequent rupture,21 22 whereas other factors such as viscosity play only a minor role 23 24. However, these results are based on a small number of IAs and must therefore be considered with caution.…”

Section: Discussionmentioning

confidence: 90%

Does the DSA reconstruction kernel affect hemodynamic predictions in intracranial aneurysms? An analysis of geometry and blood flow variations

Berg

Saalfeld

Voß

et al. 2017

J NeuroIntervent Surg

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Section: Discussionmentioning

confidence: 90%

Does the DSA reconstruction kernel affect hemodynamic predictions in intracranial aneurysms? An analysis of geometry and blood flow variations

Berg

Saalfeld

Voß

et al. 2017

J NeuroIntervent Surg

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“…They showed a better agreement, although not statistically significant, between the low‐flow regions and regions of thrombus deposition when a non‐Newtonian rheology was used. Morales et al studied the effect of blood rheology on steady flow simulations in three aneurysms before and after coiling; in untreated aneurysms, the Newtonian model overestimated intrasaccular velocities by up to 16% in space‐averaged velocities with a maximum of 45% in pointwise comparisons; these increased up to 55% in space‐averaged velocities with a maximum of 700% in pointwise comparisons in coiled aneurysms; space‐averaged WSS differed by up to 2 and 12% between the two rheological models in the untreated and coiled aneurysms, respectively, while the Newtonian model overestimated the WSS in some cases and underestimated the WSS in others. These results demonstrate again the magnification of non‐Newtonian effects in slow flow regions.…”

Section: Vascular Surface and Blood Flow Modelingmentioning

confidence: 99%

Virtual endovascular treatment of intracranial aneurysms: models and uncertainty

Sarrami‐Foroushani

Lassila

Frangi

2017

WIREs Mechanisms of Disease

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Virtual endovascular treatment models (VETMs) have been developed with the view to aid interventional neuroradiologists and neurosurgeons to pre-operatively analyze the comparative efficacy and safety of endovascular treatments for intracranial aneurysms. Based on the current state of VETMs in aneurysm rupture risk stratification and in patient-specific prediction of treatment outcomes, we argue there is a need to go beyond personalized biomechanical flow modeling assuming deterministic parameters and error-free measurements. The mechanobiological effects associated with blood clot formation are important factors in therapeutic decision making and models of post-treatment intra-aneurysmal biology and biochemistry should be linked to the purely hemodynamic models to improve the predictive power of current VETMs. The influence of model and parameter uncertainties associated to each component of a VETM is, where feasible, quantified via a random-effects meta-analysis of the literature. This allows estimating the pooled effect size of these uncertainties on aneurysmal wall shear stress. From such meta-analyses, two main sources of uncertainty emerge where research efforts have so far been limited: (1) vascular wall distensibility, and (2) intra/intersubject systemic flow variations. In the future, we suggest that current deterministic computational simulations need to be extended with strategies for uncertainty mitigation, uncertainty exploration, and sensitivity reduction techniques. WIREs Syst Biol Med 2017, 9:e1385. doi: 10.1002/wsbm.1385 For further resources related to this article, please visit the WIREs website.

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“…It is shown in [16] that even for a slow blood ow inside the aneurysm bag between microcoils the consideration of non-Newtonian properties of blood is not determinative.…”

Section: Mathematical Modelmentioning

confidence: 99%

Nonstationary Hemodynamics Modelling in a Cerebral Aneurysm of a Blood Vessel

Yanchenko

Cherevko²,

Чупахин

et al. 2014

Russian Journal of Numerical Analysis and Mathematical Modelling

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Computer simulation is carried out for unsteady hemodynamics in a cerebral aneurysm of a blood vessel. Using the data of a real patient obtained in medical examination and during surgery, we reconstruct the 3D geometry of the anomaly, calculate hydrodynamic parameters of blood ow ( ow velocity, streamline distribution, pressure, shear stress on walls, energy ux) and the deformation and stresses of the vessel walls. The calculations were performed for the following three cases: in the presence of an aneurysm, immediately after stent deployment changing the geometry of the vessel, and one year after the surgery. It is shown what changes of hydrodynamic and mechanical quantities characterize a successful surgery.The vascular system of the brain is highly susceptible to anomalies and pathologies due to peculiar intensity of its work in comparison with other organs. Cerebral arterial aneurysms are the most common anomalies. They are a pathological local expansion of a vessel caused by in ation of one layers of its wall, namely, intima, which is the most subtle and least durable. This violates the geometry of the vessel and normal blood ow in it. Since the aneurysm dome is thinner than the vessel wall, in most cases there is a risk of rupture just at this place, which leads to hemorrhage. The aneurysm treatment scenario depends on many factors.The hemodynamics in a neighbourhood of an aneurysm is intensively studied now. The in uence of the geometry of the stent and vascular intracranial aneurysms were considered in [3,5]. A simulation of owredirecting stent deployment was performed in [15]. An evaluation of stresses on the wall of an abdominal aortic aneurysms was done in [10]. The simulation results for the ow with an installed stent in the abdominal aorta was described in [12]. Mechanical properties of stents were studied in [13].Currently, the outcome of the surgery depends on the skill of a particular surgeon. The medical aspects of the problem were described in details in [7]. This paper is aimed to application of the methods of mathematical modelling to this complicated area.Stents are often used for the surgery of arterial aneurysms without neck or aneurysms located in the bifurcation (branching) of vessels. There are many designs of stents used for di erent purposes. Any stent is a delicate, generally cylindrical, metal, or plastic construction. The stent is delivered to the place with an intravascular instrument and then is spread inside with a special removable bulb which increases its diameter and presses it into the vessel wall. The design of the stent ensures the preservation of its straightened con guration. In this paper we consider coarse elastic stents which practically do not block the lumen of the vessel but, due to their elasticity, gradually correct pathological bends of vessels. The stenting was not aimed at strengthening the walls in the zone of aneurysm and hence stents are positioned so that they do not touch initially the dome of the aneurysm. Mechanical properties of vessel walls in the zone...

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Newtonian and non-Newtonian blood flow in coiled cerebral aneurysms

Cited by 93 publications

References 25 publications

Does the DSA reconstruction kernel affect hemodynamic predictions in intracranial aneurysms? An analysis of geometry and blood flow variations

Does the DSA reconstruction kernel affect hemodynamic predictions in intracranial aneurysms? An analysis of geometry and blood flow variations

Virtual endovascular treatment of intracranial aneurysms: models and uncertainty

Nonstationary Hemodynamics Modelling in a Cerebral Aneurysm of a Blood Vessel

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