Next generation covered stents made from nanocomposite materials: A complete assessment of uniformity, integrity and biomechanical properties

Farhatnia, Yasmin; Pang, Jun; Darbyshire, Arnold; Dee, Ryan; Tan, Aaron; Seifalian, Alexander M.

doi:10.1016/j.nano.2015.07.002

Cited by 28 publications

(14 citation statements)

References 50 publications

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“…Biofilm formation experiments on polystyrene ZnO QDs coated surfaces demonstrated no significant differences related with the particle morphology. Nevertheless, notable differences were observed in terms of the type of bacteria studied allowing a reduction in biofilm formation only for Gram-positive bacteria [ 91 ]. De Fátima Montemor et al studied the antibacterial and antibiofilm effect of nano-and micro-sized ZnO coatings against MRSA.…”

Section: Zno Nanoplatforms For Bacterial Infectionmentioning

confidence: 99%

ZnO Nanostructures for Drug Delivery and Theranostic Applications

2018

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In the last two decades, zinc oxide (ZnO) semiconductor Quantum dots (QDs) have been shown to have fantastic luminescent properties, which together with their low-cost, low-toxicity and biocompatibility have turned these nanomaterials into one of the main candidates for bio-imaging. The discovery of other desirable traits such as their ability to produce destructive reactive oxygen species (ROS), high catalytic efficiency, strong adsorption capability and high isoelectric point, also make them promising nanomaterials for therapeutic and diagnostic functions. Herein, we review the recent progress on the use of ZnO based nanoplatforms in drug delivery and theranostic in several diseases such as bacterial infection and cancer.

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Section: Zno Nanoplatforms For Bacterial Infectionmentioning

confidence: 99%

ZnO Nanostructures for Drug Delivery and Theranostic Applications

2018

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“…Conceptually, the thinnest struts provide low blood flow perturbance and easy strut nesting to the vessel wall and also additional flexibility and conformability during the process of implantation [16]. Flow dynamics based on strut thickness is shown in Figure 2.…”

Section: Methodsmentioning

confidence: 99%

Clinical Outcomes of World’s Thinnest (50 μmr) Strut Biodegradable Polymer Coated Everolimus-Eluting Coronary Stent System in Real-World Patients

Patted

Turiya

et al. 2018

Cardiol Res

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BackgroundThe thinnest strut platform is revolutionary improvement into the field of percutaneous coronary intervention. The aim of this study was to assess the safety and performance of world’s thinnest (50 µm) strut biodegradable polymer coated Evermine 50™ everolimus-eluting coronary stent system (EES) in real-world patients with coronary artery disease.MethodsThis was a prospective, single-arm, single-center, post-marketing study in real-world patients. A total of 251 patients with de novo coronary artery lesion (lengths < 44 mm) and/or in-stent restenosis were enrolled and implanted with at least one Evermine 50 EES. The safety endpoint was major adverse cardiac events (MACE), composite of cardiac death, myocardial infarction (MI) attributed to the target vessel and clinically-driven target lesion revascularization (CD-TLR), at 6-month follow-up.ResultsOut of 251 patients enrolled (mean age: 58.20 ± 9.92 years and 193 males), 48.6% and 45.4% patients were diabetic and hypertensive, respectively. A total of 343 lesions were intervened successfully with Evermine 50 out of 474 identified lesions (1.89 lesions per patients). Average stent length and diameter were 23.50 ± 12.21 mm and 2.83 ± 0.23 mm, respectively. At 6-month follow-up, the incidence of MACE was two (0.8%) in the form of one (0.4%) cardiac death and one (0.4%) CD-TLR. In addition, there was no definite or probable stent thrombosis reported up to 6-month follow-up.ConclusionsIn the present study, lower rate of MACE was demonstrated, which reaffirms favourable clinical safety and performance of world’s thinnest (50 µm) strut Evermine 50 EES in real-world patients with coronary artery disease.

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“…Interface strength as a function of temperature and humidity is described by the peeling test in ASTM D903‐98(2017) . This analysis was successfully applied for polyurethane‐based coatings, or to evaluate the effect of surface functionalization onto coating adhesion . The amount of peeled coating surface is calculated by the Cross Hatch Tape test, according to ASTM D3359‐02 .…”

Section: Introductionmentioning

confidence: 99%

Adhesion properties of poly(methylmethacrylate‐co‐n‐butylmethacrylate) copolymers in stent coatings

Gagliardi

2019

J of Applied Polymer Sci

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This work explores the adhesion properties of polymer solutions and thin coatings obtained by different‐composition poly(methylmethacrylate‐co‐n‐butylmethacrylate) copolymers. Surface wettability, work of adhesion, and work of spreading are calculated for solutions. Increasing amounts of n‐butylmethacrylate lead to higher values of work of adhesion, measured over two stent‐like flat surfaces (AISI 316L and pyrolytic carbon). The same moiety induces the solution viscosity increase and the decrease of the work of spreading and allows obtaining more homogeneous coatings. Adhesion of thin coatings is tested in dry (cross‐cut test) and wet (immersion) conditions. Adhesion tests of coatings obtained by solvent casting reflect thermodynamic parameters evaluated for solutions. Coatings show better strength in cross‐cut tests and a prolonged adhesion in wet conditions by raising the n‐butylmethacrylate fraction. The same trends are confirmed in commercial devices. In conclusion, the study of thermodynamic solution/substrate interactions can explain coating properties. The proposed approach is worthwhile to improve deposition procedures based on polymer solutions. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47814.

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Next generation covered stents made from nanocomposite materials: A complete assessment of uniformity, integrity and biomechanical properties

Cited by 28 publications

References 50 publications

ZnO Nanostructures for Drug Delivery and Theranostic Applications

ZnO Nanostructures for Drug Delivery and Theranostic Applications

Clinical Outcomes of World’s Thinnest (50 μmr) Strut Biodegradable Polymer Coated Everolimus-Eluting Coronary Stent System in Real-World Patients

Adhesion properties of poly(methylmethacrylate‐co‐n‐butylmethacrylate) copolymers in stent coatings

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