2013
DOI: 10.1111/ina.12072
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Next-generation DNA sequencing reveals that low fungal diversity in house dust is associated with childhood asthma development

Abstract: Dampness and visible mold in homes are associated with asthma development, but causal mechanisms remain unclear. The goal of this research was to explore associations among measured dampness, fungal exposure, and childhood asthma development without the bias of culture-based microbial analysis. In the low-income, Latino CHAMACOS birth cohort, house dust was collected at age 12 months, and asthma status was determined at age 7 years. The current analysis included 13 asthma cases and 28 controls. Next-generation… Show more

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Cited by 160 publications
(158 citation statements)
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“…However, such an average was performed based on the counts of four different sampling seasons, whereas our samples were mainly obtained during late summer and autumn. Results from the CHAMACOS birth cohort study in Salinas Valley, California, also showed higher values of OTU than the ones noted here, with a fungal diversity between 29 and 142 OTU per sample and a median value of 80.5 (Dannemiller et al, 2013). Such differences might, however, be due to some methodological constraints, including sample collection procedure (regular vacuum cleaner against high volume surface sampler) and preservation method adopted (-20 • C versus -80 • C) (Dannemiller et al, 2013;Rintala et al, 2012).…”
Section: Discussioncontrasting
confidence: 49%
“…However, such an average was performed based on the counts of four different sampling seasons, whereas our samples were mainly obtained during late summer and autumn. Results from the CHAMACOS birth cohort study in Salinas Valley, California, also showed higher values of OTU than the ones noted here, with a fungal diversity between 29 and 142 OTU per sample and a median value of 80.5 (Dannemiller et al, 2013). Such differences might, however, be due to some methodological constraints, including sample collection procedure (regular vacuum cleaner against high volume surface sampler) and preservation method adopted (-20 • C versus -80 • C) (Dannemiller et al, 2013;Rintala et al, 2012).…”
Section: Discussioncontrasting
confidence: 49%
“…These results together indicate one possible explanations of the high diversity in winter, which could be that to maintain the indoor air temperature during winter, all of the openings are closed and the ventilation rates are reduced to minimal, which in turn increases the indoor bioaerosol particles and thus increases microbial diversity. The indoor fungal diversity information might be useful in terms of health and exposure evaluations of animals and farmers working in swine houses, as indoor fungal diversity have been shown to be associated with asthma development2324.…”
Section: Resultsmentioning
confidence: 99%
“…Until now, the assessment of the urban microbiome in dust has been only considered in a few studies. Those had small sample sizes (not exceeding 100 subjects) or were studies mainly focused on exposure assessment rather than on health outcomes (Adams et al 2013a, 2013b, 2014; Barberán et al 2015; Dannemiller et al 2014, 2016; Kembel et al 2012; Lynch et al 2014). Moreover, to conclude on the impact of early exposure to the urban dust microbiome in relation to health outcomes in later childhood, cohort studies with a prospective study design and appropriate analyses methods are required.…”
Section: Introductionmentioning
confidence: 99%