Next-Generation Examination, Diagnosis, and Personalized Medicine in Periodontal Disease

Kikuchi, Takeshi; Hayashi, Jun-ichiro; Mitani, Akio

doi:10.3390/jpm12101743

Cited by 15 publications

(5 citation statements)

References 187 publications

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“…Laser-generated light energy can interact with tissue in four distinct ways [ 57 , 58 ]. All four of these processes: reflection, transmission, scattering, and absorption, are possible.…”

Section: Light-sources In Dentistry Lasersmentioning

confidence: 99%

The Involvement of Photobiology in Contemporary Dentistry—A Narrative Review

Luchian

Budală

Baciu

et al. 2023

IJMS

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Light is an emerging treatment approach that is being used to treat many diseases and conditions such as pain, inflammation, and wound healing. The light used in dental therapy generally lies in visible and invisible spectral regions. Despite many positive results in the treatment of different conditions, this therapy still faces some skepticism, which has prevented its widespread adoption in clinics. The main reason for this skepticism is the lack of comprehensive information about the molecular, cellular, and tissular mechanisms of action, which underpin the positive effects of phototherapy. However, there is currently promising evidence in support of the use of light therapy across a spectrum of oral hard and soft tissues, as well as in a variety of important dental subspecialties, such as endodontics, periodontics, orthodontics, and maxillofacial surgery. The merging of diagnostic and therapeutic light procedures is also seen as a promising area for future expansion. In the next decade, several light technologies are foreseen as becoming integral parts of modern dentistry practice.

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“…Laser-generated light energy can interact with tissue in four distinct ways [ 57 , 58 ]. All four of these processes: reflection, transmission, scattering, and absorption, are possible.…”

Section: Light-sources In Dentistry Lasersmentioning

confidence: 99%

The Involvement of Photobiology in Contemporary Dentistry—A Narrative Review

Luchian

Budală

Baciu

et al. 2023

IJMS

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“…Precision medicine not only enhances treatment effectiveness but also minimizes the trialand-error aspect of periodontal care. By focusing on the unique genetic and biological profiles of patients, it holds the potential to revolutionize the management of periodontal disease, offering more targeted and efficient therapies while improving overall oral health outcomes [65,66].…”

Section: Precision Medicine In Periodontal Diseasementioning

confidence: 99%

Present and Future Treatment Modalities for the Mitigation and Cure of Periodontal Diseases

Mukherjee

2023

OJDOH

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Periodontal disease is a serious global health issue amongst people of all age groups. Non-surgical and surgical treatments, emerging and investigational therapies, lifestyle and systemic health management are amongst the available treatment strategies of periodontal diseases and disorders. However, certain lacunae are associated with these conventional treatment modalities. Conventional formulations available for managing periodontal diseases are tablets, hydrogels, films, wafers, fibre strips, dental devices, etc. These formulations are composed of antibacterial and antiinflammatory drugs. Chronic use of these formulations may lead to several adverse drug reactions. To overcome these drawbacks, advanced research is necessary for the development of non-invasive, cost effective, biocompatible, advanced technologies and regimen such as gene therapy, tissue engineering, nanotechnology, proteomics, vaccines, development of some novel dental formulations and some regimens for the mitigation and cure of several periodontal diseases. In this review, we elaborately discuss the clinical aspects of periodontitis and its available treatment modalities and management strategies with novel approaches for the development of modern therapeutic policies. They would lead to the opening of new avenues in the field of periodontology and provide better patient compliance.

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“…The periodontal pocket accumulates various bacteria, mainly pathogens like Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, which have been recognized as the primary cause of advanced disease of periodontitis [6,7]. These pathogens are Gram-negative, facultative anaerobes, a nonmotile bacterium often detected in association with localized aggressive periodontitis, a severe infection of the periodontium [8]. Effective periodontal treatment involves the removal or inhibition of bacterial growth on tooth surfaces and within the crevicular pocket through methods like mechanical scaling, root planning, and medications.…”

Section: Introductionmentioning

confidence: 99%

Levofloxacin HCl-Loaded Eudragit L-Based Solvent Exchange-Induced In Situ Forming Gel Using Monopropylene Glycol as a Solvent for Periodontitis Treatment

Senarat

Tuntarawongsa

Lertsuphotvanit

et al. 2023

Gels

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Solvent exchange-induced in situ forming gel (ISG) is currently an appealing dosage form for periodontitis treatment via localized injection into the periodontal pocket. This study aims to apply Eudragit L and Eudragit S as matrix components of ISG by using monopropylene glycol as a solvent for loading levofloxacin HCl for periodontitis treatment. The influence of Eudragit concentration was investigated in terms of apparent viscosity, rheological behavior, injectability, gel-forming behavior, and mechanical properties. Eudragit L-based formulation presented less viscosity, was easier to inject, and could form more gel than Eudragit S-based ISG. Levofloxacin HCl-loading diminished the viscosity of Eudragit L-based formulation but did not significantly change the gel formation ability. Higher polymer loading increased viscosity, force-work of injectability, and hardness. SEM photographs and µCT images revealed their scaffold formation, which had a denser topographic structure and less porosity attained owing to higher polymer loading and less in vitro degradation. By tracking with fluorescence dyes, the interface interaction study revealed crucial information such as solvent movement ability and matrix formation of ISG. They prolonged the drug release for 14 days with fickian drug diffusion kinetics and increased the release amount above the MIC against test microbes. The 1% levofloxacin HCl and 15% Eudragit L dissolved in monopropylene glycol (LLM15) was a promising ISG because of its appropriate viscosity (3674.54 ± 188.03 cP) with Newtonian flow, acceptable gel formation and injectability (21.08 ± 1.38 N), hardness (33.81 ± 2.3 N) and prolonged drug release with efficient antimicrobial activities against S. aureus (ATCC 6538, 6532, and 25923), methicillin-resistant S. aureus (MRSA) (S. aureus ATCC 4430), E. coli ATCC 8739, C. albicans ATCC 10231, P. gingivalis ATCC 33277, and A. actinomycetemcomitans ATCC 29522; thus, it is the potential ISG formulation for periodontitis treatment by localized periodontal pocket injection.

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Next-Generation Examination, Diagnosis, and Personalized Medicine in Periodontal Disease

Cited by 15 publications

References 187 publications

The Involvement of Photobiology in Contemporary Dentistry—A Narrative Review

The Involvement of Photobiology in Contemporary Dentistry—A Narrative Review

Present and Future Treatment Modalities for the Mitigation and Cure of Periodontal Diseases

Levofloxacin HCl-Loaded Eudragit L-Based Solvent Exchange-Induced In Situ Forming Gel Using Monopropylene Glycol as a Solvent for Periodontitis Treatment

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