Next-Generation Hydrogels as Biomaterials for Biomedical Applications: Exploring the Role of Curcumin

Madamsetty, Vijay Sagar; Vazifehdoost, Maryam; Alhashemi, Samira Hossaini; Davoudi, Hesam; Zarrabi, Ali; Dehshahri, Ali; Fekri, Hojjat Samareh; Mohammadinejad, Reza; Thakur, Vijay Kumar

doi:10.1021/acsomega.2c07062

Cited by 21 publications

(7 citation statements)

References 224 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, its poor solubility and rapid hydrolytic degradation in aqueous solution severely impede its clinical applications. Although many encapsulation methods or delivery vehicles have been developed, the controlled release of pharmaceutical ingredients at the site of action remains a major challenge. − Curcumin has the ability to inhibit the growth of Helicobacter pylori and reduce the incidence of gastric cancers. , Considering the extremely acidic environment in the stomach, investigating the pH-controlled curcumin release from IIIGGHK assemblies is valuable for its applications.…”

Section: Results and Discussionmentioning

confidence: 99%

Controlled Assembly and Disassembly of Higher-Order Peptide Nanotubes

Ma,

Zhao,

Jiang

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

The controlled peptide self-assembly and disassembly are not only implicated in many cellular processes but also possess huge application potential in a wide range of biotechnology and biomedicine. β-sheet peptide assemblies possess high kinetic stability, so it is usually hard to disassemble them rapidly. Here, we reported that both the self-assembly and disassembly of a designed short β-sheet peptide IIIGGHK could be well harnessed through the variations of concentration, pH, and mechanical stirring. Microscopic imaging, neutron scattering, and infrared spectroscopy were used to track the assembly and disassembly processes upon these stimuli, especially the interconversion between thin, left-handed protofibrils and higher-order nanotubes with superstructural right-handedness. The underlying rationale for these controlled disassembly processes mainly lies in the fact that the specific His−His interactions between protofibrils were responsive to these stimuli. By taking advantage of the peptide self-assembly and disassembly, the encapsulation of the hydrophobic drug curcumin and its rapid release upon stimuli were achieved. Additionally, the peptide hydrogels facilitated the differentiation of neural cells while maintaining low cell cytotoxicity. We believe that such dynamic and reversible structural transformation in this work provides a distinctive paradigm for controlling the peptide self-assembly and disassembly, thus laying a foundation for practical applications of peptide assemblies.

show abstract

Section: Results and Discussionmentioning

confidence: 99%

Controlled Assembly and Disassembly of Higher-Order Peptide Nanotubes

Ma,

Zhao,

Jiang

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…Hydrogels and nanogels have been suggested as prospective drug delivery platforms over a decade; however, very few researchers have examined the administration of curcumin as hydro/nanogels, utilizing them in cancer treatment. 106 Several polymeric hydrogel NPs delivery systems have been created using synthetic and organic polymers. 107,108 Chitosan, chitin, and alginate have been substantially used to generate nanogels among natural polymers.…”

Section: Nanogelmentioning

confidence: 99%

Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Ahmad,

Ahmad

et al. 2024

Cell Biochemistry & Function

View full text Add to dashboard Cite

Curcumin is a natural compound derived from turmeric and can target malignant tumor molecules involved in cancer propagation. It has potent antioxidant activity, but its effectiveness is limited due to poor absorption and rapid elimination from the body. Various curcumin derivatives have also shown anticancer potential in in‐vitro and in‐vivo models. Curcumin can target multiple signaling pathways involved in cancer development/progression or induce cancer cell death through apoptosis. In addition, curcumin and its derivatives could also enhance the effectiveness of conventional chemotherapy, radiation therapy and reduce their associated side effects. Lately, nanoparticle‐based delivery systems are being developed/explored to overcome the challenges associated with curcumin's delivery, increasing its overall efficacy. The use of an imaging system to track these formulations could also give beneficial information about the bioavailability and distribution of the nano‐curcumin complex. In conclusion, curcumin holds significant promise in the fight against cancer, especially in its nanoform, and could provide precise delivery to cancer cells without affecting normal healthy cells.

show abstract

“…Curcumin, the main used curcuminoid, with antitumoral, antioxidant, antiarthritic, anti-amyloid, anti-ischemic, and anti-inflammatory properties, is poorly absorbed through skin barriers. Because of its hydrophobicity, low bioavailability, and chemical instability, different formulations are studied to improve its therapeutic efficacity including as nanoemulsions, nanohydrogels, nanoparticles in smart film and nanoparticles in hydrogels, nanostructured lipid carriers, lipid-based self-nanoemulsifying systems, ethosomes, and microneedles [ 90 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 ].…”

Section: Natural Products From Plants Used In Medical Devicesmentioning

confidence: 99%

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Isopencu,

Covaliu-Mierlă,

Deleanu

2023

Plants

View full text Add to dashboard Cite

Transdermal delivery devices and wound dressing materials are constantly improved and upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, and cost effectiveness. Therefore, researchers in the field have shown an increasing interest in using natural compounds as constituents for such systems. Plants, as an important source of so-called “natural products” with an enormous variety and structural diversity that still exceeds the capacity of present-day sciences to define or even discover them, have been part of medicine since ancient times. However, their benefits are just at the beginning of being fully exploited in modern dermal and transdermal delivery systems. Thus, plant-based primary compounds, with or without biological activity, contained in gums and mucilages, traditionally used as gelling and texturing agents in the food industry, are now being explored as valuable and cost-effective natural components in the biomedical field. Their biodegradability, biocompatibility, and non-toxicity compensate for local availability and compositional variations. Also, secondary metabolites, classified based on their chemical structure, are being intensively investigated for their wide pharmacological and toxicological effects. Their impact on medicine is highlighted in detail through the most recent reported studies. Innovative isolation and purification techniques, new drug delivery devices and systems, and advanced evaluation procedures are presented.

show abstract

Next-Generation Hydrogels as Biomaterials for Biomedical Applications: Exploring the Role of Curcumin

Cited by 21 publications

References 224 publications

Controlled Assembly and Disassembly of Higher-Order Peptide Nanotubes

Controlled Assembly and Disassembly of Higher-Order Peptide Nanotubes

Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Contact Info

Product

Resources

About