Next generation immunology: the quest for a universal vaccine

Influenza causes around 3–5 million cases of severe illness each year, with 290 000–650 000 deaths worldwide. People older than 65 years of age account for up to 90% of deaths from influenza. Vaccination is the most effective way to protect those at risk of morbidity and mortality. This article briefly summarises the vaccination recommendations for the 2018/19 influenza season and stresses the importance of increasing uptake in eligible groups in general practice.

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Influenza vaccines: an introduction

Greener¹

2023

Practice Nursing

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Seasonal influenza is a leading cause of severe respiratory infections and deaths. During an influenza infection, the immune system produces inflammatory mediators, which are largely responsible for the systemic symptoms and complications. Vaccines remain the most effective way to prevent influenza-related respiratory disease and non-respiratory complications despite antivirals. Numerous studies support the benefits of influenza vaccination, especially in high-risk groups. However, the effectiveness of the influenza vaccine varies markedly depending on the match between the circulating strains and those in the vaccine, and the recipient’s characteristics. Influenza vaccines are, in general, well-tolerated. Research could lead to more effective and, potentially, universal influenza vaccines.

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Next generation immunology: the quest for a universal vaccine

Cited by 3 publications

References 8 publications

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Influenza vaccines: an introduction

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