Next-generation peptide nanomaterials: molecular networks, interfaces and supramolecular functionality

Abstract

With improved understanding of the design rules for self-assembling peptides, new challenges will be faced to incorporate these materials into dynamic systems of higher complexity and functionality. In this highlight article we discuss very recent advances in these areas. Three areas are covered: (i) molecular networks based on peptides and their interactions including (bio-) catalytically driven systems; (ii) supramolecular functionality, both in the context of biological and nanotechnology applications; (iii) approaches to effectively interface peptides with synthetic and biological materials. We also discuss challenges and opportunities for the design of a new generation of peptide nanomaterials for the next decade.

Graphene-based wireless bacteria detection on tooth enamel

“…Aptamer-functionalized nanotube electrodes have been shown to detect single bacterial cells in real time 26 . Further, we have recently shown that phage display can be utilized to determine peptide sequences that selectively bind to CNTs and graphene 8,[27][28][29] . This has enabled the generation of bifunctional peptides containing a carbon nanomaterial recognition moiety combined with an analyte binder to non-covalently selfassemble and impart selectivity on graphene sensor arrays.…”

Thermodynamics, morphology, and kinetics of early-stage self-assembly of π-conjugated oligopeptides

“…[1][2][3][4][5][6][7][8] Assembly can be triggered by environmental variables such as pH, temperature, and salt concentration. [9][10][11] The morphology of self-assembled peptidic aggregates can be tuned by the amino acid sequence, and endowed with useful electronic and optoelectronic properties by the incorporation of aromatic groups into the peptide backbone that establish inter-peptide π -conjugation upon assembly. [10,12,13] The resultant electrical and electronic propertieselectron transport or exciton coupling, for example -provide the basis for a diverse array of organic electronic devices, such as light-emitting diodes, field-effect transistors, and solar cells.…”

“…[9][10][11] The morphology of self-assembled peptidic aggregates can be tuned by the amino acid sequence, and endowed with useful electronic and optoelectronic properties by the incorporation of aromatic groups into the peptide backbone that establish inter-peptide π -conjugation upon assembly. [10,12,13] The resultant electrical and electronic propertieselectron transport or exciton coupling, for example -provide the basis for a diverse array of organic electronic devices, such as light-emitting diodes, field-effect transistors, and solar cells. [14][15][16][17][18] Deterministic control of the structure, stability, and kinetics of self-assembled organic electronics by tuning monomer chemistry and environmental conditions presents a powerful route to the fabrication of 'designer materials' possessing desirable structural and functional properties.…”

Natively Unfolded State for Engineering Nanoscale Fibrillar Arrays

“…The strategy has proven to be efficient for engineering specific nano-to microscopic architectures, amongst which fibrillar systems appear to dominate. [10,11] In part, this is because fiber formation is a single-mode polymerization process that is relatively straightforward to emulate, in part, because of the significance it has in normal and pathological cellular processes. However, for engineering and biomedical purposes fiber architectures impose strict limitations.…”