2020
DOI: 10.21037/atm.2020.03.17
|View full text |Cite
|
Sign up to set email alerts
|

Next-generation sequencing diagnosis of severe pneumonia from fulminant psittacosis with multiple organ failure: a case report and literature review

Abstract: This study includes a retrospective analysis of the diagnosis and treatment of a case of severe pneumonia from fulminant psittacosis with multiple organ failure. Next-generation sequencing (NGS) of the pathogen was conducted. The purpose of this study was to summarize the clinical, laboratory, and imaging characteristics of the case and to improve understanding of the value of NGS in the diagnosis of severe community-acquired pneumonia (CAP). Fulminant psittacosis can be manifested as severe pneumonia with rap… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

1
28
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 38 publications
(29 citation statements)
references
References 26 publications
1
28
0
Order By: Relevance
“…Transmission to humans often occurs via the inhalation of contaminated aerosols from the excretions of infected birds. The clinical presentation of psittacosis can range from subclinical or an influenza-like illness to fulminant severe pneumonia with multi-organ failure (2)(3)(4)(5)(6)(7). It has been estimated that C. psittaci is the causative organism of approximately 1% of cases of communityacquired pneumonia (CAP), when it is known as C. psittaci pneumonia (8).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Transmission to humans often occurs via the inhalation of contaminated aerosols from the excretions of infected birds. The clinical presentation of psittacosis can range from subclinical or an influenza-like illness to fulminant severe pneumonia with multi-organ failure (2)(3)(4)(5)(6)(7). It has been estimated that C. psittaci is the causative organism of approximately 1% of cases of communityacquired pneumonia (CAP), when it is known as C. psittaci pneumonia (8).…”
Section: Introductionmentioning
confidence: 99%
“…With early identification and appropriate antibiotic therapy, the infection is rarely fatal (9). However, in recent years, fulminant severe C. psittaci pneumonia has been described more frequently using metagenomic nextgeneration sequencing (mNGS) in clinical practice (2,3,10), and it is crucial to understand its clinical characteristics and identify its risk factors. There have some case reports or case series reported about clinical manifestations of C. psittaci pneumonia, but the sample sizes are limited (11,12).…”
Section: Introductionmentioning
confidence: 99%
“…SP is a type of pneumonia with severe disease, rapid progress, and poor prognosis. Although there are various treatment measures such as powerful anti-infective treatment and ventilator-assisted ventilation, SP has rapid changes in disease condition, complex inflammatory response, and multiple organ dysfunction syndrome (MODS), which is difficult to treat and expensive, and the prognosis is poor and the mortality rate is high [4,5]. Primary bronchial lung cancer, referred to as lung cancer (LC), is a malignant tumor that occurs in the bronchial mucosal epithelium, which can grow into the bronchial lumen and/or adjacent lung tissue and can pass through lymphatic blood or transbronchial metastasis [6].…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, mNGS is less affected by prior antibiotic exposure [12]. Several studies have discussed the potential of mNGS in diagnosing psittacosis or legionnaire's disease [6][7][8]37]. In our study, all 17 psittacosis patients and 9 LP patients were diagnosed with the help of mNGS.…”
Section: Discussionmentioning
confidence: 83%