Next generation ultrasound platforms for theranostics

Oddo, Letizia; Cerroni, Barbara; Domenici, Fabio; Bedini, Angelico; Bordi, F.; Chiessi, Ester; Gerbes, Stefan; Paradossi, Gaio

doi:10.1016/j.jcis.2016.12.030

Cited by 27 publications

(32 citation statements)

References 67 publications

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“…In this respect, the strict interconnection between some pivotal multifunctional applications of our PVA MBs and their own peculiar crosslinked-PVA structure has been proven (e.g. the possibility of modifying the external surface of the shell, the targeting ability, and the biodistribution) [7,21]. From the compelling translational opportunities that the class of micro-structured PVA materials offers in biomedical engineering and theranostics, what emerged was the essential need to clarify how ageing affects the acoustic and structural properties of PVA-shelled MBs.…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 94%

“…Some of them are presently employed as invaluable and minimally invasive intravenous imaging tools which support early diagnosis [1][2][3]. Many developments have addressed the optimisation of their acoustic behaviour, targeting properties, cargo and release capacity as drug delivery systems, and their ability to support other imaging methods [1,[4][5][6][7]. The complexity of tasks that have requested to turn UCAs into next-generation theranostic tools [1] represents the challenge to be tackled with an integrated approach, which requires expertise in medical imaging, biology, physics, and chemistry.…”

Section: Introductionmentioning

confidence: 99%

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Long-term physical evolution of an elastomeric ultrasound contrast microbubble

Domenici

Brasili

Oddo

et al. 2019

Journal of Colloid and Interface Science

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Hypothesis One of the main assets of crosslinked polymer-shelled microbubbles (MBs) as ultrasound-active theranostic agents is the robustness of the shells, combined with the chemical versatility in modifying the surface with ligands and/or drugs. Despite the long shelf-life, subtle modifications occur in the MB shells involving shifts in acoustic, mechanical and structural properties. Experiments We carried out a long-term morphological and acoustic evolution analysis on elastomeric polyvinyl-alcohol (PVA)-shelled MBs, a novel platform accomplishing good acoustic and surface performances in one agent. Confocal laser scanning microscopy, acoustic spectroscopy and AFM nanomechanics were integrated to understand the mechanism of PVA MBs ageing. The changes in the MB acoustic properties were framed in terms of shell thickness and viscoelasticity using a linearised oscillation theory, and compared to MB morphology and to nanomechanical analysis. Findings We enlightened a novel, intriguing ageing time evolution of the PVA MBs with double behaviour with respect to a crossover time of ∼50 days. Before, significant changes occur in MB stiffness and shell thickness, mainly due to a massive release of entangled PVA chains. Then, the MB resonance frequency increases together with shell thickening and softening. Our benchmark study is of general interest for emerging viscoelastomeric bubbles towards personalised medicine.

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Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Long-term physical evolution of an elastomeric ultrasound contrast microbubble

Domenici

Brasili

Oddo

et al. 2019

Journal of Colloid and Interface Science

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“…Due to their magnetic properties, with a diameter ranging from a few nanometers up to approximately 100 nm, iron oxide particles have been evaluated and used in several magnetic resonance technology-based biomedical applications such as multifunctional theranostic complexes combining tumor targeting, imaging as well as cancer nanotherapy in personalized cancer treatment [91,92,93,94,95,96,97,98,99,100]. The superparamagnetic iron oxide NPs (SPIONs) are most often used, and the subpopulation of ultrasmall SPIONs denoted as USPIOs defined as having a diameter of less than ~20 nm.…”

Section: Nanoparticles For Prostate and Breast Cancermentioning

confidence: 99%

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

Elgqvist

2017

IJMS

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Prostate and breast cancer are the second most and most commonly diagnosed cancer in men and women worldwide, respectively. The American Cancer Society estimates that during 2016 in the USA around 430,000 individuals were diagnosed with one of these two types of cancers, and approximately 15% of them will die from the disease. In Europe, the rate of incidences and deaths are similar to those in the USA. Several different more or less successful diagnostic and therapeutic approaches have been developed and evaluated in order to tackle this issue and thereby decrease the death rates. By using nanoparticles as vehicles carrying both diagnostic and therapeutic molecular entities, individualized targeted theranostic nanomedicine has emerged as a promising option to increase the sensitivity and the specificity during diagnosis, as well as the likelihood of survival or prolonged survival after therapy. This article presents and discusses important and promising different kinds of nanoparticles, as well as imaging and therapy options, suitable for theranostic applications. The presentation of different nanoparticles and theranostic applications is quite general, but there is a special focus on prostate cancer. Some references and aspects regarding breast cancer are however also presented and discussed. Finally, the prostate cancer case is presented in more detail regarding diagnosis, staging, recurrence, metastases, and treatment options available today, followed by possible ways to move forward applying theranostics for both prostate and breast cancer based on promising experiments performed until today.

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“…Invited speaker Benoît Larrat from the Alternative Energies and Atomic Energy Commission followed with MRI-guided ultrasound-mediated blood-brain barrier opening in non-human primates using passive cavitation detection feedback control [21]. Barbara Cerroni from the University of Rome Tor Vergata spoke about targeting brain tumour vasculature with RGD-decorated microbubbles [22].…”

mentioning

confidence: 99%

“…Katrien Vanderperren from Ghent University presented a poster on renal ageing in cats assessed by contrast-enhanced ultrasound [24] and a poster on the evaluation of renal perfusion using contrast-enhanced ultrasound in cats with chronic kidney disease [25]. Letizia Oddo from the University of Rome Tor Vergata showed in a poster the next generation of ultrasound platforms for theranostics [22]. Florian Gailliègue from Institut Gustave Roussy showed a poster with numerical and experimental characterisation of a biochip for sonoporation studies [26].…”

mentioning

confidence: 99%

Acoustic bubbles in therapy: Recent advances with medical microbubbles, clouds, and harmonic antibubbles

Postema

Bouakaz

2018

Applied Acoustics

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EditorialAlthough the use of microbubbles has become common in ultrasound diagnostics, microbubbles are not that often seen in therapeutic applications. To share recent advances in the development and application of microbubbles in therapy, LE STUDIUM Loire Valley Institute for Advanced Studies and Inserm Research unit U1253: Imaging and Brain of the University of Tours organised an international conference on this topic. The event was held on 23 and 24 October, 2017, in the Hôtel de Ville of Tours, France, and hosted by Michiel Postema and Ayache Bouakaz from the University of Tours.Plenary sessions covered a wide range of topics, including bubble physics, bubble acoustic phenomena, bubble engineering and design, in-vitro evaluation, preclinical validations, and clinical studies. The conference was attended by 70 scientists, medical profesionals, and industrial representatives (cf. Figure 1).

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Next generation ultrasound platforms for theranostics

Cited by 27 publications

References 67 publications

Long-term physical evolution of an elastomeric ultrasound contrast microbubble

Long-term physical evolution of an elastomeric ultrasound contrast microbubble

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

Acoustic bubbles in therapy: Recent advances with medical microbubbles, clouds, and harmonic antibubbles

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