2021
DOI: 10.3390/biomedicines9080889
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NF-κB and Human Cancer: What Have We Learned over the Past 35 Years?

Abstract: Transcription factor NF-κB has been extensively studied for its varied roles in cancer development since its initial characterization as a potent retroviral oncogene. It is now clear that NF-κB also plays a major role in a large variety of human cancers, including especially ones of immune cell origin. NF-κB is generally constitutively or aberrantly activated in human cancers where it is involved. These activations can occur due to mutations in the NF-κB transcription factors themselves, in upstream regulators… Show more

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Cited by 31 publications
(17 citation statements)
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“…The nuclear factor-κB (NFκB) family of transcription factors is a master regulator of immune functions. The dysregulated activation of this pathway contributes to the pathogenesis of multiple diseases, including autoimmune and inflammatory diseases, and cancers [71][72][73]. BRT affects the NFκB pathway, notably via an induced up-regulation of proteins p50 and p65, and down-regulation of phospho-p65, as shown in PANC-1 pancreatic cancer cells [64].…”
Section: Interference With the Nfκb Pathwaymentioning
confidence: 99%
“…The nuclear factor-κB (NFκB) family of transcription factors is a master regulator of immune functions. The dysregulated activation of this pathway contributes to the pathogenesis of multiple diseases, including autoimmune and inflammatory diseases, and cancers [71][72][73]. BRT affects the NFκB pathway, notably via an induced up-regulation of proteins p50 and p65, and down-regulation of phospho-p65, as shown in PANC-1 pancreatic cancer cells [64].…”
Section: Interference With the Nfκb Pathwaymentioning
confidence: 99%
“…A family of inhibitory proteins normally sequesters the different NF-κB proteins in the cytoplasm [ 257 , 258 ]. The adequate activation of the major NF-κB pathway involves two major signalling pathways, the canonical and non-canonical (or alternative) pathways, both being instrumental to regulate the cellular processes governed by NF-κB [ 256 , 259 ]. In the past two decades our knowledge on the NF-κB pathway has considerably expanded, positioning this pathway as an instrumental orchestrator in the regulation of inflammation and in the development of different tumours, including UM [ 257 , 260 , 261 ].…”
Section: Immunohistochemistry-based Novel Prognostic Biomarkers In Uveal Melanomamentioning
confidence: 99%
“…Thus, there is a need to identify the new target genes of STATs to fully understand how JAK/STATs can be used for the therapeutic intervention of solid tumors. Indeed, solid tumors contain aberrantly activated transcription factors—either through mutation of the transcription factor itself or through mutation of upstream signaling cascades leading to its activation ( Qureshy et al, 2020 ; Gilmore, 2021 ). Therefore, understanding the genes regulated by STATs may provide insights into the pathophysiology of solid tumors in which they are inappropriately activated and may unravel novel targets for therapeutic intervention.…”
Section: Introductionmentioning
confidence: 99%